Mixed gel skeleton ibuprofen cataplasm and preparation technique thereof

Abstract

The invention discloses mixed gel skeleton ibuprofen cataplasm and a preparation technique thereof and belongs to the technical field of medicines. The mixed gel skeleton ibuprofen cataplasm preparation is mainly composed of raw material drugs (non-steroidal anti-inflammatory drug ibuprofen and the slat form thereof ), mixed gel skeletons (sodium polyacrylate, crosslinked sodium polyacrylate and the like), plasticizers (sodium alginate, polyving akohol, polyethylene glycol, triethyl citrate and the like), thickening agents (polyvinylpyrrolidone, carbomer, methylcellulose, ethyl cellulose and the like ), humectants (glycerol, sorbitol, propylene glycol, 1,3-butanediol and the like), pH regulators (citric acid, tartaric acid, lactic acid and the like ), penetration enhancers (menthol, diethylene glycol monoethyl ether, octanoic acid capric acid polyethylene glycol glyceride, polyethylene glycol glyceride and the like), water, a backing layer and a release film. The mixed gel skeleton ibuprofen cataplasm and the preparation technique thereof have the following characteristics that (1) the drug loading capacity of the preparation is high, the main drug and addition agents are stable in a hydrogel mechanism and low in drug blocking performance, the preparation can be released continuously for 12 hours, and the residual drug amount is less after using; (2) organic solvents are not used in a prescription and in the preparation process, so that skin irritation is avoided; (3) good adhesiveness is achieved, and residues are avoided at the time of peeling; and (4) the preparation process is simple and convenient to implement, and pollution is avoided.

Description

technical field [0001] The invention relates to a mixed gel skeleton ibuprofen cataplasm, which has an excellent transdermal absorption effect, is non-irritating to the skin, and can achieve stable and long-lasting drug release when used locally, and belongs to the technical field of medicine. Background technique [0002] Ibuprofen is recognized as the safest non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects [1] . It is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis, etc. The main analgesic mechanism of ibuprofen is to reduce the synthesis of prostaglandins at pain or inflammatory sites by inhibiting COX. Other possible mechanisms include inhibition of inflammatory cell adhesion and platelet aggregation, reduction of lymphocyte reactivity and modulation of inhibitory cytokine production. Inhibition of cartilage proteoglycan production, and improved ...

AI Technical Summary

Problems solved by technology

However, it is difficult to control the degree and speed of crosslinking, and it is often impossible to coat due to too fast crosslinking speed or too strong strength, which has become an important reason hindering the wide application of this technology.

And the drug-loaded cross-linked cataplasm often affects the release of the drug due to the increase in the blockage of the drug due to the excessive cross-linking strength.

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