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Nanoporous magnesium silicate microsphere/PBS (poly(butylene succinate)) composite scaffold, composite scaffold coated with protein, preparation methods and application

A polybutylene succinate and composite scaffold technology, which is applied in coatings, pharmaceutical formulations, and medical sciences, can solve problems such as slow bone regeneration and osseointegration, poor osteogenic differentiation, and slow cell response. Achieve the effects of promoting proliferation, good compatibility, and increasing adsorption capacity

Inactive Publication Date: 2017-12-01
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the shortcomings of the bone repair materials commonly used in the prior art, such as slow cell response, poor osteogenic differentiation ability, low nutrition, low activity, slow bone regeneration and osseointegration speed, etc., and provides a nano Porous magnesium silicate microsphere / polybutylene succinate composite scaffold, protein-coated composite scaffold, preparation method and application

Method used

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  • Nanoporous magnesium silicate microsphere/PBS (poly(butylene succinate)) composite scaffold, composite scaffold coated with protein, preparation methods and application
  • Nanoporous magnesium silicate microsphere/PBS (poly(butylene succinate)) composite scaffold, composite scaffold coated with protein, preparation methods and application
  • Nanoporous magnesium silicate microsphere/PBS (poly(butylene succinate)) composite scaffold, composite scaffold coated with protein, preparation methods and application

Examples

Experimental program
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Effect test

Embodiment 1

[0088] (1) Preparation of nanoporous magnesium silicate microspheres (NMS)

[0089] Accurately weigh 0.7 g of cetyltrimethylammonium bromide (CTAB) and dissolve it in 33 mL of deionized water, and place it in a constant temperature water bath at 35°C. After CTAB was completely dissolved, 7 mL of 1 mol / L ammonia water, 3.6 mL of tetraethyl orthosilicate (TEOS) and 2.47 g of magnesium nitrate hexahydrate were added in sequence. After fully reacting for 4 hours, the solution turned into a milky white suspension, and a white precipitate was collected after centrifugation. After washing twice with alcohol and once with deionized water, place it in an electric blast drying oven at 60°C for 24 hours and dry it. Finally, the obtained product was placed in a muffle furnace, sintered at 600° C., kept for 3 hours, CTAB was removed, and a white powder was obtained, namely NMS.

[0090] (2) Preparation of nanoporous magnesium silicate microspheres / polybutylene succinate composite scaffol...

Embodiment 2

[0099] (1) Preparation of nanoporous magnesium silicate microspheres (NMS)

[0100] Accurately weigh 0.6g of cetyltrimethylammonium bromide (CTAB) and dissolve it in 31mL of deionized water, and place it in a constant temperature water tank at 33°C. After CTAB was completely dissolved, 8 mL of 0.5 mol / L ammonia water, 3.4 mL of tetraethyl orthosilicate (TEOS) and 2.40 g of magnesium nitrate hexahydrate were sequentially added. After fully reacting for 3 hours, the solution turned into a milky white suspension, and a white precipitate was collected after centrifugation. After washing twice with alcohol and once with deionized water, place it in an electric blast drying oven at 50°C for 26 hours and dry it. Finally, the obtained product was placed in a muffle furnace, sintered at 500° C., kept for 4 hours, CTAB was removed, and a white powder was obtained, namely NMS.

[0101] (2) Preparation of nanoporous magnesium silicate microspheres / polybutylene succinate composite scaffo...

Embodiment 3

[0110] (1) Preparation of nanoporous magnesium silicate microspheres (NMS)

[0111] Accurately weigh 0.8g of cetyltrimethylammonium bromide (CTAB) and dissolve it in 33mL of deionized water, and place it in a constant temperature water tank at 35°C. After CTAB was completely dissolved, 8 mL of 1.5 mol / L ammonia water, 3.8 mL of tetraethyl orthosilicate (TEOS) and 2.54 g of magnesium nitrate hexahydrate were sequentially added. After fully reacting for 5 hours, the solution turned into a milky white suspension, and a white precipitate was collected after centrifugation. After washing twice with alcohol and once with deionized water, place it in an electric blast drying oven at 70°C for 22 hours and dry it. Finally, the obtained product was placed in a muffle furnace, sintered at 700° C., kept for 2 hours, CTAB was removed, and a white powder was obtained, namely NMS.

[0112] (2) Preparation of nanoporous magnesium silicate microspheres / polybutylene succinate composite scaffold...

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Abstract

The invention discloses a nanoporous magnesium silicate microsphere / PBS (poly(butylene succinate)) composite scaffold, a composite scaffold coated with protein, preparation methods and an application. A preparation method of a genipin crosslinking protein coating supported drug-nanoporous magnesium silicate microsphere / PBS composite scaffold comprises the following steps: PBS is mixed with an organic solvent, the mixture is then mixed with nanoporous magnesium silicate microspheres and a pore-foaming agent, the mixture is subjected to pressing forming, the organic solvent and the pore-foaming agent are removed, and the composite scaffold is obtained after drying; the composite scaffold is soaked in a resveratrol buffer solution, and the resveratrol supported composite scaffold is obtained after drying; a gliadin solution is added to the resveratrol supported composite scaffold, the gliadin protein coating supported composite scaffold is obtained after drying and then mixed with a genipin solution for a crosslinking reaction, and a product is obtained. The composite scaffolds have higher in-vitro degradation performance and bioactivity, good cell compatibility, high drug adsorption capacity and good drug slow release effect, and the effective acting time of drugs can be prolonged.

Description

technical field [0001] The invention relates to a nanoporous magnesium silicate microsphere / polybutylene succinate composite support, a protein-coated composite support, a preparation method and an application. Background technique [0002] Bone is an important part of the human body. Bone defects caused by external trauma, bone diseases (bone tumors, osteomyelitis, etc.) repair. Therefore, for the research and development of bone repair and replacement materials, it is of great significance to repair or replace diseased or damaged bone tissue in vivo to restore its original shape or function. [0003] Bone implant materials should not only have excellent safety and biocompatibility, but also need to have excellent osteogenesis and degradability, certain mechanical properties, fast repair of bone defects, and shorten the time required for patient rehabilitation. Organic / organic composites such as chitosan / PBSu have relatively poor bioactivity and degradability in vitro. I...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/02A61L27/34A61L27/28A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/025A61L27/18A61L27/28A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/404A61L2300/412A61L2300/602A61L2400/12A61L2420/02A61L2420/06A61L2430/02C08L89/00C08L67/02
Inventor 苏佳灿陈晓曹烈虎潘盼盼魏杰
Owner SHANGHAI CHANGHAI HOSPITAL
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