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Compound yolk antibody powder for resisting diarrhea of dogs and cats, and preparation method thereof

A yolk antibody and antibody technology, applied in the direction of antibodies, chemical instruments and methods, antibacterial drugs, etc., can solve the problems of low antibody titer, little commercial application value, poor use effect, etc., and achieve the effect of reducing the incidence rate

Inactive Publication Date: 2017-11-10
赛法特(长沙)生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, supplements for prevention of common diseases in dogs and cats have not been reported
In addition, the inventor found in the research that in the preparation method of egg yolk antibody, the whole virus and whole bacteria are usually inactivated to prepare the antigen to immunize laying hens. However, such treatment leads to weak antigen specificity, The antibody titer is low, the use effect is poor, the use cost is high, and the commercial application value is not great

Method used

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  • Compound yolk antibody powder for resisting diarrhea of dogs and cats, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] According to the scale of producing 100kg compound yolk antibody powder for anti-dog and cat diarrhea, the following steps are adopted for production:

[0030] a Immunogen preparation: the recombinant antigens of parvovirus, coronavirus, rotavirus and enterotoxigenic Escherichia coli F4\F5\F6\F18 tetravalent pili protein were added with Freund’s adjuvant to make parvovirus immunogen, Coronavirus immunogen, rotavirus immunogen and enterotoxigenic Escherichia coli tetravalent immunogen, wherein the enterotoxigenic Escherichia coli tetravalent immunogen is obtained by genetic engineering and contains F4 / F5 / F6 / F18 Escherichia coli antigen Tetravalent immunogens;

[0031] b Immunization of laying hens: use the parvovirus immunogen, coronavirus immunogen, rotavirus immunogen and enterotoxigenic Escherichia coli quadrivalent immunogen to immunize laying hens respectively, inoculate 3 times, and detect by ELISA After the yolk antibody titer ≥ 16000:1, start collecting eggs;

...

experiment Embodiment 1

[0035] In this experimental example, the preventive effect of the compound yolk antibody powder of the present invention on diarrhea in puppies was studied.

[0036] 1. Test method: Select 160 puppies with similar body weight and age, and randomly divide them into control group and test group, including 80 test groups and 80 control groups, and the test period is 30 days. The test group was fed with feed containing 0.2% compound egg yolk antibody powder of Example 1 of the present invention, and the control group was fed with ordinary feed, and the feeding management of the two groups was the same.

[0037] 2. Test results: The test results are shown in Table 1.

[0038] Table 1

[0039]

[0040] As can be seen from the above results, the survival rate of the test group increased by 6.25% compared with the control group, and the incidence of diarrhea decreased by 10%. Therefore, the compound egg yolk antibody powder of the present invention effectively prevents diarrhea in...

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Abstract

The invention relates to compound yolk antibody powder, a preparation method and a preparation thereof, wherein the compound yolk antibody powder contains an anti-parvovirus antibody, an anti-coronavirus antibody, an anti-rotavirus antibody and an anti-enterotoxin type Escherichia coli tetravalent antibody. According to the present invention, the compound yolk antibody powder can prevent and treat the bacterial diarrhea of dogs and cats, can replace the use of antibiotics to reduce the morbidity and the mortality of dogs and cats, and further contains lecithin so as to promote the skin brightening and the hair brightening of cats and dogs and reduce the occurrence of skin diseases.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine and biomedicine, and in particular relates to a compound egg yolk antibody powder for anti-diarrhea of ​​dogs and cats and a preparation method thereof. Background technique [0002] As the most important companion animals for humans, dogs and cats play an important role in our lives. However, in China, the research on disease prevention and control of dogs and cats is seriously lagging behind; dogs and cats suffer from various stresses of unfavorable factors and invasion of pathogens in our living environment, which has a great impact on their gastrointestinal health , especially diarrhea in dogs and cats. Pathogenic diarrhea in dogs and cats is more common in infections such as parvovirus, coronavirus and rotavirus, as well as conditionally pathogenic enterotoxin-type E. The drug resistance is too strong, and the effect of using antibiotics is not ideal, which makes it more difficu...

Claims

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Application Information

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IPC IPC(8): C07K16/08C07K16/10C07K16/12C07K16/02A61K39/42A61K39/40A61P31/14A61P31/04A61P31/20
CPCA61K2039/507A61K2039/552C07K16/02C07K16/081C07K16/10C07K16/1232
Inventor 王清平方林吴冉
Owner 赛法特(长沙)生物技术有限公司
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