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Preparation method of collagen-coated carbon nanotube composite material

A technology of composite materials and carbon nanotubes, applied in the direction of carbon compounds, chemical instruments and methods, medical preparations of non-active ingredients, etc. Poor stability and other problems, to achieve high drug loading, avoid agglomeration, and good dispersion

Inactive Publication Date: 2020-07-21
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a preparation method of collagen-coated carbon nanotube composite material, which is a method of combining the magnetic liquid phase stirring method and the hydrogel method on the surface of the functionalized carbon nanotube Coating the collagen layer, and then preparing the preparation method of the collagen-coated carbon nanotube composite material, overcomes the preparation method of the gelatin-carbon nanotube composite material in the prior art, the carbon nanotubes are prone to agglomeration, and it is difficult to reach the components The uniform dispersion and low production efficiency; when the prepared gelatin-carbon nanotube composite material is used as a drug carrier material, the hidden dangers of poor biocompatibility, poor drug loading and drug release ability, and toxicity have not been completely eliminated. Defects

Method used

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  • Preparation method of collagen-coated carbon nanotube composite material
  • Preparation method of collagen-coated carbon nanotube composite material
  • Preparation method of collagen-coated carbon nanotube composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0029] Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 10nm at a mass ratio of 0.55:1, and mix the weighed The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.01mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 2h, ferric chloride is uniformly impregnated in hydroxyapatite to obtain suspension I, suspension I: 25% (mass percentage) ammonia water=100:1 in volume ratio, add 25% (mass percentage) to above suspension I percentage) of ammonia water, and continue to stir for 1 hour to obtain suspension II, place the formed suspension II in an ultrasonic disperser, and disperse ultrasonically at a frequency of 20 kHz for 40 min to fully react ferric chloride and ammonia water to form Fe(OH...

Embodiment 2

[0039] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0040] Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 40nm in a mass ratio of 1.2:1, and mix the weighed ferric chloride hexahydrate with a mechanical stirrer at a speed of 250r / min. The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.15mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 3h, ferric chloride is uniformly impregnated in the hydroxyapatite to obtain the suspension I, the suspension I: 25% (mass percentage) ammonia water=60:1 in the volume ratio, add 25% (mass percentage) to the above suspension I percentage) of ammonia water, and continue to stir for 2.5 hours to obtain suspension II. Place the formed suspension II in an ultrasonic disperser, and ultrasonically disperse...

Embodiment 3

[0046] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0047] Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 60nm according to the ratio of 1.75:1 in mass ratio, and under the condition of stirring at a speed of 400r / min with a mechanical stirrer, the weighed The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.3mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 4h, ferric chloride is uniformly impregnated in hydroxyapatite to obtain suspension I, suspension I: 25% (mass percentage) ammonia water=20:1 in volume ratio, add 25% (mass percentage) to above-mentioned suspension I percentage) of ammonia water, and continue to stir for 4 hours to obtain suspension II, place the formed suspension II in an ultrasonic disperser, and disperse it by...

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Abstract

The invention discloses a preparation method of a collagen cladded carbon nano-tube composite material and relates to a carbon nano-tube material. The preparation method is a preparation method for preparing the collagen cladded carbon nano-tube composite material by in-situ cladding a collagen layer on the surface of a functionalized carbon nano-tube by combing a magnetic liquid phase stirring method and a hydrogel method. The preparation method comprises the following steps of preparing carbon nano-tube-hydroxyapatite composite powder; preparing the functionalized carbon nano-tube; and preparing the collagen cladded carbon nano-tube composite material by the technical method of combing the magnetic liquid phase stirring method and a hydrogel method. The defects that the carbon nano-tube is easily agglomerated, uniform dispersion of components is difficult and production efficiency is low in the preparation method of a collagen-carbon nano-tube composite material in the prior art are overcome; and when the prepared collagen-carbon nano-tube composite material is used as a medicine carrying material, the detects that the biocompatibility is still relatively poor, medicine-carrying and medicine-releasing abilities are poor, and hidden danger of toxin is not thoroughly eliminated generally are overcome.

Description

technical field [0001] The technical solution of the invention relates to a carbon nanotube material, specifically a method for preparing a collagen-coated carbon nanotube composite material. Background technique [0002] Carbon nanotubes have a unique graphite tubular structure and have excellent electrical, magnetic and wave-absorbing properties. Due to the high stability of C-C covalent bonds and the perfect structure of carbon nanotubes, carbon nanotubes exhibit much higher mechanical properties than existing known bone tissue engineering reinforcement materials, and their strength is about 100 times that of steel, while the density It is only one-sixth of steel; at the same time, carbon nanotubes have extremely high surface energy, which leads to enhanced adsorption with osteoblasts and weakened adsorption with fibroblasts, so that carbon nanotubes have a good relationship with osteoblasts. Capacitance. However, carbon nanotubes have certain defects of toxicity, low b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/04C01B32/162C01B32/168
CPCA61K47/02A61K47/42C01P2002/72C01P2004/03C01P2004/04C01P2004/13C01P2004/64C01P2004/80
Inventor 李海鹏孙熙雯李袁军范佳薇杨爽孙连城刘斐然曹航畅刘雯
Owner HEBEI UNIV OF TECH
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