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POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel as well as preparation method and application thereof

A hydrogel and hybridization technology, applied in medical science, prosthesis, etc., can solve the problem of photoinitiator toxicity and other problems, achieve good mechanical strength, reduce damage or loss, and fast gelation time

Active Publication Date: 2017-09-01
HUBEI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main disadvantage of these preparation methods is that the photoinitiators, HDI, MDI, etc. used are toxic, and the reaction needs to be carried out in organic solvents, and the in vitro biocompatibility research on materials can only be limited to 2D cell culture.

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  • POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel as well as preparation method and application thereof
  • POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel as well as preparation method and application thereof
  • POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel as well as preparation method and application thereof

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Embodiment Construction

[0036] The principles and features of the present invention are described below in conjunction with examples, which are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0037] 1. Preparation of POSS-PEG hybrid hydrogel

[0038] The POSS-PEG hybrid hydrogel was prepared by the following method: 4-arm-PEG-MAL (Beijing Jiankai Technology Co., Ltd.) and POSS-SH (Sigma Company) were dissolved in 3 mL of tetrahydrofuran, stirred at room temperature for 3.5 hours and then removed. Solvent to obtain POSS-PEG prepolymer; then POSS-PEG prepolymer and matrix metalloprotease substrate peptide (Shanghai Jier Biochemical Technology Co., Ltd.) are dissolved in 3mL of triethanolamine with pH 7.4, and mixed uniformly to obtain a pregel solution; Finally, the above pregel solution was transferred to five 600 μl molds, and reacted in a 37° C. biochemical incubator to prepare a hydrogel. The molecular weight of 4-arm-PEG-MAL in the pr...

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Abstract

The invention relates to a preparation method of POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel. The preparation method comprises the following steps: carrying out Michael addition reaction on 4-arm-PEG-MAL and POSS-SH to obtain a POSS-PEG pre-polymer; taking a matrix metalloproteinase substrate peptide as a cross-linking agent, carrying out the Michael addition reaction on the matrix metalloproteinase substrate peptide and the POSS-PEG pre-polymer and crossly linking to form gel, so as to obtain the POSS-PEG hybrid hydrogel. The POSS-PEG hybrid hydrogel provided by the invention has good mechanical strength and the mechanical strength of the POSS-PEG hybrid hydrogel can be finely regulated and controlled through changing the molecular weight of the 4-arm-PEG-MAL and the mol ratio of the POSS-SH to the 4-arm-PEG-MAL; meanwhile, the POSS-PEG hybrid hydrogel can be prepared in a triethanolamine with low concentration and gel formation time is short; the damages or loss on seed cells or medicines loaded on the POSS-PEG hybrid hydrogel can be reduced as much as possible under the condition that basic physicochemical properties are ensured.

Description

technical field [0001] The invention relates to the field of tissue engineering, and more particularly relates to a POSS-PEG hybrid hydrogel, a preparation method thereof and a tissue engineering scaffold prepared therefrom. Background technique [0002] Tissue engineering technology has great potential in biomedical applications, such as repairing, replacing biological functions of damaged or diseased tissues. One of the key factors for the success of tissue engineering techniques is the selection of an appropriate scaffold material. In order to achieve tissue reconstruction, scaffold materials should meet the following conditions: (1) good biocompatibility; (2) strong mechanical properties; (3) high porosity and sufficient pore size; (4) biodegradability and an appropriate degradation rate. [0003] Polyethylene glycol (PEG) hydrogel is a very attractive scaffold material for tissue engineering. It has good biocompatibility, non-toxicity, low immunogenicity, anti-adsorpt...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08L71/02A61L27/18A61L27/52
CPCA61L27/18A61L27/52C08J3/075C08J3/245C08J2371/02C08L71/02
Inventor 卢翠芬沈金瑞李鹤玲余晶晶董念国刘宗涛胡行健
Owner HUBEI UNIV
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