High-strength antimicrobial dialdehyde starch crosslinked chitosan membane and preparation method and use thereof

Abstract

The present invention relates to a high-strength antimirobial dialdehyde starch cross-linked chitosan film, its production method and application. It is made up by using 1-3 wt% of chitosan acetic acid aqueos solution and 2-7 wt% of dialdehyde starch and adopting the processes of fully stirring, mixing, centrifugal defoaming, film-making, washing with acid, washing with water, drying by airing toobtain the invented product dried film. Said chitosan cross-linked film has excellent mechanical strength, flexibility and good antibacterial function, and has no toxic side effect for human body. Said chitosan cross-linked film has good bacteria-inhibiting action, can be used as clinical medical material for reducing infection of wound.

Description

Technical field [0001] The invention relates to a high-strength antibacterial dialdehyde starch cross-linked chitosan film, and a preparation method and application thereof. Background technique [0002] Chitosan (CS) is β-(1→4)-2-amino-D-glucopyranose, which has good biological activity, biocompatibility, biodegradability, antibacterial, hemostatic, and anti-inflammatory And promote biological functions such as wound healing. The linear molecular chain structure of chitosan makes it have excellent film-forming properties, and its film material can be used as artificial skin, hemostatic material and wound dressing material. So far, there has been almost no practical commercial application of chitosan membranes in industrial production. One of the most important reasons is that chitosan membranes are fragile and have poor mechanical properties. Therefore, improving the mechanical strength of chitosan membrane materials Become the key to expand its application. At present, cross-li...

AI Technical Summary

Problems solved by technology

So far, almost no chitosan film has been commercially produced in commercial applications. One of the most important reasons is that the chitosan film is brittle and has poor mechanical properties. Therefore, it is necessary to improve the mechanical strength of the chitosan film material. become the key to expanding its application

At present, cross-linking agents such as epichlorohydrin, glutaraldehyde, and dibasic acid anhydride are widely used to cross-link chitosan to improve the mechanical properties of chitosan films, but these cross-linking agents themselves are highly toxic substances. Harmful to human health, its application as a medical material is limited