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Hyperfluorescence nitrogen doped carbon quantum dots and preparing method and application thereof

A technology of carbon quantum dots and fluorescence quantum yield, applied in the preparation of highly fluorescent nitrogen-doped carbon quantum dots, the application of highly fluorescent nitrogen-doped carbon quantum dots in biological imaging, the field of highly fluorescent nitrogen-doped carbon quantum dots , can solve the problems of few fluorescent active sites of carbon quantum dots, low nitrogen-doped fluorescence efficiency, complex preparation, etc., and achieve good biocompatibility and water solubility, wide application value, and good biocompatibility

Inactive Publication Date: 2017-08-25
兴义民族师范学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the hydrothermal method is considered to be a simple and efficient method for preparing fluorescent carbon quantum dots. It is to place the selected carbon source in a closed hydrothermal reactor. The carbonization of the carbon source produces carbon quantum dots. The hydrothermal method has the advantages of low cost, high yield, and simple post-processing. Low rate (mostly less than 15%), selectivity, etc. become the bottleneck of development
In recent years, heteroatom doping and other methods have been used to overcome it, improve its yield and increase active sites. Among them, nitrogen doping is the most researched method at present, but the fluorescence efficiency of nitrogen doping is generally low and the preparation is complicated.

Method used

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  • Hyperfluorescence nitrogen doped carbon quantum dots and preparing method and application thereof
  • Hyperfluorescence nitrogen doped carbon quantum dots and preparing method and application thereof
  • Hyperfluorescence nitrogen doped carbon quantum dots and preparing method and application thereof

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Embodiment 1

[0026] A preparation method for highly fluorescent nitrogen-doped carbon quantum dots, comprising the following steps:

[0027] (1) Dissolve L-citrulline in deionized water to a concentration of 0.010g / mL, oscillate ultrasonically for 5 minutes, and react at 180°C for 8 hours by hydrothermal method to obtain a carbon dot solution;

[0028] (2) The carbon dot solution was ultracentrifuged at 17000r / min for 20min, and then filtered with a 0.22μm filter membrane to obtain a carbon dot solution with a nitrogen content of 15.5%, an average fluorescence lifetime of 4.41ns, and a fluorescence quantum yield of 20.3%.

Embodiment 2

[0030] A preparation method for highly fluorescent nitrogen-doped carbon quantum dots, comprising the following steps:

[0031] (1) Dissolve L-citrulline in deionized water to a concentration of 0.020 g / mL, oscillate ultrasonically for 10 min, and react at 200°C for 12 h by hydrothermal method to obtain a carbon dot solution;

[0032] (2) The carbon dot solution was ultracentrifuged at 18000r / min for 20min, and then filtered with a 0.22μm filter membrane to obtain a carbon dot solution with a nitrogen content of 19.2%, an average fluorescence lifetime of 4.46ns, and a fluorescence quantum yield of 32.9%.

Embodiment 3

[0034] A preparation method for highly fluorescent nitrogen-doped carbon quantum dots, comprising the following steps:

[0035] (1) Dissolve L-citrulline in deionized water to a concentration of 0.040g / mL, ultrasonically oscillate for 20 minutes, and react at 220°C for 24 hours by hydrothermal method to obtain a carbon dot solution;

[0036] (2) The carbon dot solution was ultracentrifuged at 20000r / min for 40min, and then filtered with a 0.22 μm filter membrane to obtain a carbon dot solution with a nitrogen content of 18.6%, an average fluorescence lifetime of 4.51ns, and a fluorescence quantum yield of 28.3%.

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Abstract

The invention discloses hyperfluorescence nitrogen doped carbon quantum dots and a preparing method and application thereof. The preparing method includes the steps that L-citrulline is dissolved in deionized water until the concentration is 0.010-0.040 g / mL, ultrasonic oscillation is carried out for 5-20 min, and a hydrothermal method is used for conducting reaction for 8-24 h at the temperature of 180-220 DEG C to obtain a carbon dot solution; the carbon dot solution is ultracentrifuged for 20-40 min at the speed of 17000-20000 r / min, and a 0.22 micrometer filter membrane is used for filtration to obtain the carbon dot solution. The invention further discloses application of the hyperfluorescence nitrogen doped carbon quantum dots in bean sprout and cervical cancer cells. The hyperfluorescence nitrogen doped carbon quantum dots are high in fluorescence efficiency, easy to prepare, low in toxicity, high in biocompatibility and water solubility and small in particle size.

Description

technical field [0001] The invention belongs to the field of carbon nanomaterials, and specifically relates to a highly fluorescent nitrogen-doped carbon quantum dot, and also relates to a preparation method of the highly fluorescent nitrogen-doped carbon quantum dot, and the application of the highly fluorescent nitrogen-doped carbon quantum dot in biological imaging in the application. Background technique [0002] Heavy metal quantum dots have been widely studied due to their excellent luminescent properties, however, most of them have high toxicity and high production cost. Exploring fluorescent materials with good biocompatibility, excellent photoluminescence performance, low toxicity, and small particle size, and meeting the applications of biological imaging, drug delivery, and fluorescent inks, has great potential application value. Fluorescent carbon quantum dots are made of carbon elements with excellent biocompatibility as the core component. Because of their nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65G01N21/64
CPCC09K11/65G01N21/64
Inventor 张仟春谢思琪王兴益付予锦李飞王苑
Owner 兴义民族师范学院
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