Binder used for simulating aptyalia pathological oral environment and application thereof

Abstract

The invention discloses a binder used for simulating aptyalia pathological oral environment and an application thereof. The method for simulating aptyalia pathological oral environment is characterized in that lactic acid is added in a NaCl solution until the pH value of the solution is 4; the binder comprises the following components by mass percentage: 40% of amorphous calcium phosphate nanoparticles and 60% of PEHB; wherein the PEHB comprises the following components by weight percentage: 42% of phenyltriglycerol dimethyl acrylate, 42% of ethoxy bisphenol A dimethacrylate, 1% of phenyl di(2,4,6-trimethylbenzoyldiphenyl) phosphorus oxide, 10% of hydroxyethyl methylacrylate, and 5% of bisphenol A glycidyl methacrylate. The binder can simultaneously perform bonding protection and inhibit caries development, can effectively realize the re-mineralization of demineralized dentine, can release the calcium and phosphor ions, neutralizes local acidic environment, can realize re-mineralization of acidic environment lacking of calcium and phosphor, and can be clinically used for preventing root caries of the elderly and rampant caries of extreme oligosialia patients.

Description

technical field [0001] The invention relates to the field of oral medical materials, in particular to a binder for simulating pathological oral environment of lack of saliva and application thereof. Background technique [0002] Saliva plays an extremely important role in the process of inhibiting the progression of dental caries; for healthy people, the saliva film always covers the surface of the tooth, and the phosphate, bicarbonate and other components in saliva give it a strong buffer capacity ; while the continuous flow of saliva takes away part of the food residue and bacteria through the swallowing process, it can also penetrate into the biofilm and neutralize the local acid production of cariogenic bacteria; in addition, saliva contains high concentrations of calcium and phosphorus particles, It can not only reduce the solubility of hydroxyapatite, reduce demineralization, but also promote the remineralization process. [0003] However, patients with saliva deficie...

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Problems solved by technology

[0003] However, patients with saliva deficiency / reduction lost all or part of this protective mechanism, and the saliva secretion function of the elderly decreased, and the incidence of root caries and the incidence of rampant caries in patients with extreme saliva reduction were significantly higher than ordinary people; When the particle reserve is greatly reduced and the acid neutralization ability is limited, the remineralization process is hindered, and the prevention and treatment of this kind of caries has not been well solved; in addition, the most widely used material in the restoration of tooth defects is Composite resin, one of the main factors affecting the long-term restoration effect due to secondary caries caused by microleakage of dentin-resin bond failure; dentin-resin bond depends on the penetration of bonding monomer into demineralized collagen The staining layer formed in the fiber, the stability of the staining layer will directly affect the bonding life; in the oral environment, the collagen fiber network can be destroyed by bacteria, enzymes, etc., resulting in denaturation of the staining layer and bonding failure; exposed The remineralization of the stained layer can not only effectively strengthen the resin-dentin bonding, but also repair the sites where caries occurs, thereby prolonging the life of composite resin-dentin bonding and inhibiting the occurrence of secondary caries However, there is no clinically available material that can simultaneously protect the bond and inhibit the progression of dental caries.

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