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A method for accelerating the remineralization of demineralized dentin assisted by direct current

A direct current and remineralization technology, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problems of restricting dentin biomimetic remineralization, difficult dentin fiber remineralization, slow speed, etc., to speed up molecular Movement speed, efficiency improvement, high safety effect

Active Publication Date: 2020-05-19
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, calcium phosphate complexes, bioactive glass ionomers, agar gel, polyamide-amine dendrimers (PAMAM) and other non-collagen analogues are commonly used in dentin remineralization to guide the biomimetic remineralization of dentin, Its action is often slow, and generally only a layer of surface mineralization can be formed on the surface of the dentin, and it is difficult to complete the remineralization of the dentin fibers
This also greatly restricts the application of dentin biomimetic remineralization

Method used

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  • A method for accelerating the remineralization of demineralized dentin assisted by direct current
  • A method for accelerating the remineralization of demineralized dentin assisted by direct current
  • A method for accelerating the remineralization of demineralized dentin assisted by direct current

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] S1. Soak the demineralized dentin slices in 20g / L sodium tripolyphosphate (TPP) solution for 24 hours to complete the phosphorylation of the demineralized dentin slices;

[0062] S2. Fix the phosphorylated demineralized dentin sheet in the middle of a double-pass tube, and put 10% casein phosphopeptide-nano-amorphous calcium phosphate (CPP-ACP) emulsion into the upper part of the double-pass tube. The dentin surface is in full contact, the lower part of the double-way tube is fixed in a solution box filled with simulated saliva, and the simulated saliva is also in full contact with the other side of the dentin sheet;

[0063] S3. Use wires to lead out the positive and negative electrodes of the electrophoresis instrument, and use crocodile clips to connect the two platinum electrodes respectively;

[0064] S4. Put the platinum sheet electrode connected to the negative electrode of the electrophoresis instrument into the upper half of the double-pass tube, and enter the ...

Embodiment 2

[0068] S1. Soak the demineralized dentin slices in 20g / L sodium tripolyphosphate (TPP) solution for 24 hours to complete the phosphorylation of the demineralized dentin slices;

[0069] S2. Fix the phosphorylated demineralized dentin sheet in the middle of a double-pass tube, and put 10% casein phosphopeptide-nano-amorphous calcium phosphate (CPP-ACP) emulsion into the upper part of the double-pass tube. The dentin surface is in full contact, the lower part of the double-way tube is fixed in a solution box filled with simulated saliva, and the simulated saliva is also in full contact with the other side of the dentin sheet;

[0070] S3. Use wires to lead out the positive and negative electrodes of the electrophoresis instrument, and use crocodile clips to connect the two platinum electrodes respectively;

[0071] S4. Put the platinum sheet electrode connected to the negative electrode of the electrophoresis instrument into the upper half of the double-pass tube, and enter the ...

Embodiment 3

[0075] S1. Soak the demineralized dentin slices in 20g / L sodium tripolyphosphate (TPP) solution for 24 hours to complete the phosphorylation of the demineralized dentin slices;

[0076] S2. Fix the phosphorylated demineralized dentin sheet in the middle of a double-pass tube, and put 10% casein phosphopeptide-nano-amorphous calcium phosphate (CPP-ACP) emulsion into the upper part of the double-pass tube. The dentin surface is in full contact, the lower part of the double-way tube is fixed in a solution box filled with simulated saliva, and the simulated saliva is also in full contact with the other side of the dentin sheet;

[0077] S3. Use wires to lead out the positive and negative electrodes of the electrophoresis instrument, and use crocodile clips to connect the two platinum electrodes respectively;

[0078] S4. Put the platinum sheet electrode connected to the negative electrode of the electrophoresis instrument into the upper half of the double-pass tube, and enter the ...

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Abstract

The invention discloses a method for accelerating and promoting demineralized dentin remineralization under the assistance of direct current, belongs to the technical field of biological material engineering, and aims to provide a method for accelerating demineralized dentin remineralization. The method comprises the following steps: S1, phosphorylating demineralized dentin tablets; S2, fixing thephosphorylated demineralized dentin tablets in the middle of a double-channel tube, putting one part of the double-channel tube into a casein phosphopeptide-nano amorphous calcium phosphate emulsion,and fixing the other part in a solution box containing simulated saliva; S3, leading out the positive electrode and the negative electrode of an electrophoresis instrument by using leads; S4, puttingan electrode connected to the negative electrode of the electrophoresis instrument into one part of a double-channel tube, allowing the tube to enter the casein phosphopeptide-nano amorphous calciumphosphate emulsion, and putting an electrode connected to the positive electrode of the electrophoresis instrument into the other part of a double-channel tube containing the simulated saliva; S5, switching on the power supply of the electrophoresis instrument to conduct electricity, and adjusting current and voltage; and S6, cleaning the dentin tablet sample obtained by the S5 so as to obtain remineralized demineralized dentin tablets.

Description

technical field [0001] The invention relates to the technical field of biomaterial engineering, in particular to a method for accelerating the remineralization of demineralized dentin assisted by direct current. Background technique [0002] Biomimetic remineralization is an important research field in minimally invasive dentistry. Repairing demineralized teeth through biomimetic remineralization can maximize the healing potential of the tooth itself, which can solve tooth sensitivity, tooth decay prevention and self-repair, etc. question. Tooth remineralization can be divided into remineralization of enamel and remineralization of dentin. The remineralization technology of tooth enamel is relatively mature, and a relatively good mineralization effect has been achieved. However, due to its special structure, the remineralization effect of dentin is often uncertain, and the remineralization speed is extremely slow. [0003] As the main structure of the tooth body, dentin i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61C5/20A61K6/884A61K6/838A61K6/76A61K6/20
CPCA61C5/20
Inventor 周洲许涛于金华李泽汉李娜葛兴云
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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