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Graphene oxide/manganese tungstate/polyethylene glycol nanometer hybrid material and preparation method thereof

A nano-hybrid material, polyethylene glycol technology, applied in wave energy or particle radiation processing materials, X-ray contrast agent preparation, general/multifunctional contrast agent, etc., can solve problems such as low sensitivity and difficult CT diagnosis, Achieve the effects of simple preparation process, excellent dispersibility and biocompatibility, and good economical practicability

Active Publication Date: 2017-07-21
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CT imaging has high resolution and short scanning time, but due to the small density difference between some lesions and surrounding tissues, CT diagnosis is also difficult, such as vascular malformations, early cancers, metastatic tumors, etc.
In addition, conventional CT scans are less sensitive

Method used

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  • Graphene oxide/manganese tungstate/polyethylene glycol nanometer hybrid material and preparation method thereof
  • Graphene oxide/manganese tungstate/polyethylene glycol nanometer hybrid material and preparation method thereof
  • Graphene oxide/manganese tungstate/polyethylene glycol nanometer hybrid material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] GO / MnWO 4 The preparation of the / PEG nanometer multifunctional material includes the following steps.

[0051] (1) Weigh 50mg Mn(NO 3 ) 2 4H 2 Dissolve O in 20mL of triethylene glycol, then disperse 70mg of GO in 20mL of triethylene glycol, stir and mix the above solution and adjust the pH value to 6;

[0052] (2) Weigh 66mg Na 2 WO 4 2H 2 O was dissolved in 5 mL of deionized water, slowly added to the mixed solution in step (1), and after stirring for 30 min, 2 mL of an aqueous solution containing 113 mg of aminocaproic acid was added to the mixed solution in (1) and (2) steps;

[0053] (3) Heat the solution obtained above to 220°C under high-speed stirring. After reacting for 2 hours, add 10 mL of triethylene glycol dissolved with 500 mg of PEG (1500), continue the reaction for 1 hour, and then naturally cool the reaction system to room temperature;

[0054] (4) The reaction solution finally obtained in the above steps was washed three times with ethanol and u...

Embodiment 2

[0060] GO / MnWO prepared in Example 1 4 / PEG nanomaterial aqueous solution was prepared as 0, 25, 50, 75, 100, 150, 200 μg / mL solutions, and the heating performance and photothermal cycle stability of the solutions were tested under 808nm laser irradiation.

[0061] Figure 5 GO / MnWO in this example 4 Visible-near-infrared spectra of materials with different concentrations of / PEG. It can be observed that the absorbance of nanomaterials in the near-infrared increases with the increase of concentration.

[0062] Figure 6 GO / MnWO in this example 4 / PEG different concentration materials at 808nm, 1.2W / cm 2 The temperature rise curve of laser irradiation for 10 minutes, which verifies the GO / MnWO 4 / PEG can produce photothermal effects under near-infrared laser irradiation.

[0063] Figure 7 GO / MnWO in this example 4 / PEG different concentration materials at 808nm, 1.2W / cm 2 In the visible-near-infrared image after 10 minutes of laser irradiation, the visible-near-infrar...

Embodiment 3

[0066] GO / MnWO prepared in Example 1 4 / PEG nanomaterial water was prepared as aqueous solutions with different concentrations, and its MRI imaging properties were obtained under the magnetic field strength of 0.5T.

[0067] Figure 9 For GO / MnWO in Example 3 4 / T of PEG material dispersed in water 1 Weighted imaging image, with the increase of solution concentration, the content of Mn element increases, T 1 The more obvious the weighted imaging effect is, the r of the material 1 The value is 11.34Mm -1 the s -1 r 2 24.06Mm -1 the s -1 ,r 2 / r 1 = 2.12, suitable as T 1 contrast agent. These data also suggest that GO / MnWO 4 / PEG nanomaterials can be used as good T 1 contrast agent.

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Abstract

The invention relates to a graphene oxide / manganese tungstate / polyethylene glycol nanometer hybrid material and a preparation method thereof. The preparation method comprises the following concrete steps: separately preparing an alcoholic solution of a divalent manganese salt and an alcoholic solution of nanometer graphene oxide and then carrying out mixing under stirring so as to prepare a mixed solution; preparing an aqueous tungstate solution; and slowly adding the aqueous tungstate solution into the mixed solution, then adding aminocaproic acid, carrying out stirring and heating, then adding polyethylene glycol again, carrying out a continuous reaction for 3 to 5 h, then successively carrying out natural cooling to room temperature, centrifugation and washing, dispersing a solid product in deionized water and carrying out ultrasonic treatment so as to obtain the nanometer hybrid material. Compared with the prior art, the preparation method provided by the invention uses easily available raw materials and is simple in process and good in economic performance and practicality; and the prepared graphene oxide / manganese tungstate / polyethylene glycol nanometer hybrid material is in a two-dimensional thin laminar shape, has excellent dispersibility and biocompatibility, outstanding photo-thermal effect and obvious imaging effect and can be used for MRI imaging, PA imaging, CT imaging or photo-thermal treatment.

Description

technical field [0001] The invention belongs to the technical field of biological inorganic nanometer materials, and relates to a graphene oxide / manganese tungstate / polyethylene glycol nano-hybrid material and its preparation. Background technique [0002] Graphene is a new material with a single-layer sheet structure composed of carbon atoms. 2 The hybridized orbitals form a hexagonal planar film with a honeycomb lattice, a two-dimensional material with a thickness of only one carbon atom. In 2004, physicists Andre Geim and Konstantin Novoselov of the University of Manchester successfully separated graphene from graphite in experiments, which made them win the 2010 Nobel Prize in Physics . In recent years, the application of nano-graphene oxide-based functional hybrids in the biomedical field has attracted widespread attention. [0003] Due to its large specific surface area, nanographene oxide can be used as a carrier of various biomolecules. Nano-graphene oxide and it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18A61K49/04A61K41/00A61P35/00
CPCA61K41/0052A61K49/0002A61K49/04A61K49/126A61K49/1896
Inventor 吴惠霞张忆雪常旭宗路艳刘燕杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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