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Fluorine-containing antibacterial coating on the surface of metal materials and preparation method thereof

A metal material, antibacterial coating technology, applied in the direction of metal material coating process, coating, pharmaceutical formulation, etc., to achieve the effect of broad-spectrum antibacterial activity

Active Publication Date: 2019-06-25
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the prior art, the present invention provides a fluorine-containing antibacterial coating on the surface of a metal material and a preparation method thereof. Plasma fluorination modification is performed on the surface of an existing medical metal material, thereby endowing the metal material with an antibacterial infection function; The method of the present invention can be widely applied to various metal medical instruments used in medical clinical fields such as orthopedics and stomatology, and can solve the bacterial infection caused by the implantation of medical metal medical instruments in existing clinics

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  • Fluorine-containing antibacterial coating on the surface of metal materials and preparation method thereof
  • Fluorine-containing antibacterial coating on the surface of metal materials and preparation method thereof
  • Fluorine-containing antibacterial coating on the surface of metal materials and preparation method thereof

Examples

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Effect test

Embodiment 1

[0060] A fluorine-containing antibacterial coating on the surface of a metal material, the coating composition includes fluorine element and R-F compound, and the coating has nano-scale holes; wherein, R is titanium, the size of the nano-scale holes is 50-200nm, and the nano-scale The volume of the pores accounts for 60% of the coating volume.

[0061] The preparation method of the above-mentioned fluorine-containing antibacterial coating on the surface of metal material titanium adopts a P150B controllable atmosphere plasma material surface treatment device, and the preparation includes the following steps:

[0062] Step 1, surface pretreatment:

[0063] Use chemical methods of mechanical grinding or acid-base treatment to remove the oil and oxide layer of metal materials, so that the surface of metal materials is smooth and clean;

[0064] Step 2, vacuum preparation:

[0065] Place the metal material in the plasma reaction chamber of the controllable atmosphere plasma mate...

Embodiment 2

[0077] A fluorine-containing antibacterial coating on the surface of a metal material, the coating composition includes oxygen element, fluorine element, R-F compound and R-O compound, and the coating has a nanoscale raised structure; wherein, R is titanium, and the nanoscale raised The size of the structure is 100-300nm, and the volume of the nanoscale hole accounts for 50% of the volume of the coating.

[0078] The preparation method of the fluorine-containing antibacterial coating on the surface of the metal material titanium adopts the same device as in Example 1, and the difference between the preparation method and Example 1 is that in step 4, argon, oxygen and tetrachloride are simultaneously introduced into the plasma reaction chamber. Fluorocarbon gas, wherein, the argon gas flow rate is 20 sccm, the carbon tetrafluoride gas flow rate is 2.0 sccm, the ratio of argon gas to oxygen gas is: 1, and other parts are exactly the same as in Example 1.

[0079] The scanning el...

Embodiment 3

[0083] A fluorine-containing antibacterial coating on the surface of a metal material, the coating composition includes oxygen elements, fluorine elements, R-F compounds and R-O compounds, and the coating has a composite structure of nanoscale holes and nanoscale protrusions; wherein, R is titanium , the size of the nano-scale hole is 50-100nm, the size of the nano-scale protrusion is 50-100nm, and the composite structure of the nano-scale hole and the nano-scale protrusion accounts for 40% of the coating volume.

[0084] The preparation method of above-mentioned metal material titanium surface fluorine-containing antibacterial coating adopts device with embodiment 1, and the difference of preparation method and embodiment 1 is that in step 4, feed argon, oxygen and Carbon tetrafluoride gas, wherein, the argon gas flow rate is 5 sccm, the carbon tetrafluoride gas flow rate is 5.0 sccm, the ratio of argon gas to oxygen gas is: 1, and other parts are exactly the same as in Exampl...

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Abstract

The invention provides a fluorine-containing anti-bacterial coating layer of the metal material surface and a preparation method thereof and belongs to the technical field of surface anti-bacterial treatment. The coating layer comprises oxygen, fluorine, a R-F compound and a R-O compound and has a nanoscale hole structure and / or a nanoscale protrusion structure, and R is one of titanium, a titanium alloy, stainless steel, a cobalt alloy, a magnesium alloy or a zinc alloy. The preparation method comprises the following steps that (1) surface pretreatment is conducted; (2) vacuum preparation is conducted; (3) argon plasma cleaning is conducted; and (4) fluorinated treatment is conducted, specifically, argon, oxygen and carbon tetrafluoride are simultaneously pumped into a plasma reaction chamber to conduct fluorinated treatment, and a plasma-treated metal material is prepared. When the fluorine-containing anti-bacterial coating layer makes contact with a bacterium solution or other solutions, fluorion is dissolved out, and the bactericidal and anti-bacterial effects are achieved; and the preparation method can obtain the anti-infective medical metal material which cannot generate cytotoxicity, and the bacterial infective problem being relevant to metal implantable instruments is solved.

Description

technical field [0001] The invention belongs to the technical field of surface antibacterial treatment, and in particular relates to a fluorine-containing antibacterial coating on the surface of a metal material and a preparation method thereof. Background technique [0002] Traditional medical metal implant materials (such as stainless steel, titanium and its alloys, and cobalt alloys) have good biocompatibility, good comprehensive mechanical properties, and corrosion resistance in biological environments, and have been widely used in clinics, such as artificial tooth roots , Orthodontic wire, crown and bridge for molars, metal gums, trays, jawbone, spine and bone joint implant materials, etc. However, the following problems have been found in the use of metal implant materials for medical treatment: [0003] 1) Surgical artificial prosthesis, even under the premise of strict implementation of surgical aseptic operation and systemic preventive anti-inflammatory treatment, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C8/36C23C8/38C23C8/28A61L27/30A61L27/50
CPCA61L27/306A61L27/50A61L2400/18A61L2420/02C23C8/28C23C8/36C23C8/38
Inventor 张二林陈绵杨磊王晓燕秦高梧
Owner NORTHEASTERN UNIV LIAONING
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