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A kind of multi-substituted 3-phenylphenol derivatives and its preparation method

A phenylphenol and polysubstituted technology, applied in the field of polysubstituted 3-phenylphenol derivatives and their preparation, can solve the problems of harsh synthesis conditions, complicated steps, etc., and achieves short reaction time, complex and diverse structures, and wide applications. Foreground effect

Active Publication Date: 2018-08-17
陕西巴斯腾科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the above synthesis conditions are relatively harsh and the steps are too cumbersome

Method used

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  • A kind of multi-substituted 3-phenylphenol derivatives and its preparation method
  • A kind of multi-substituted 3-phenylphenol derivatives and its preparation method
  • A kind of multi-substituted 3-phenylphenol derivatives and its preparation method

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Embodiment 1

[0035] A kind of multi-substituted 3-phenylphenol derivatives, its structural formula is:

[0036]

[0037] A kind of preparation method of substituted 3-phenylphenol derivatives, described preparation method comprises the following steps:

[0038] (1) With 830mmol sodium hydride as a catalyst, 200mmol dimethyl malonate and 440mmol propargyl bromide were added to 210mL anhydrous acetonitrile in an ice-water bath, stirred and reacted for 8 hours, the product was washed with water, extracted with ethyl acetate, and Press and spin dry to obtain a brownish-yellow solid product, namely compound 1;

[0039] (2) Mix 80mmol compound 1 with 200mmol phenylethynyl bromide in Pd(PPh 3 ) 2 Cl 2 / CuI(2.56mmol / 0.85mmol) anhydrous and oxygen-free catalytic system, the molar ratio of Pd(PPh 3 ) 2 Cl 2 : CuI=3:1, with 336mmol triethylamine as base, 150mL anhydrous acetonitrile as solvent, stirring and reacting at room temperature for 12 hours, the product was washed with water, extract...

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Abstract

The invention provides poly-substituted 3-phenyl phenol derivatives and a preparation method thereof. Compared with the prior art, a series of novel poly-substituted 3-phenyl phenol derivatives is provided. Compared with common poly-substituted 3-phenyl phenol derivatives, the prepared poly-substituted 3-phenyl phenol derivatives have a multi-ring structure, the structure is more complicated, and thus the provided derivatives have a wide application in industries such as chemical engineering, clinical medicine, materials, and the like. Furthermore, the provided preparation method has the advantages of simpleness, high efficiency, and short reaction time.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and specifically relates to a multi-substituted 3-phenylphenol derivative and a preparation method thereof. Background technique [0002] Phenol, commonly known as carbolic acid, is a widely used organic chemical raw material. Phenol is used in the plastics industry to make epoxy resins, nylon 66, polycarbonate and phenolic resins; in the pharmaceutical industry to make drugs such as aspirin, chloroquine, phenolphthalein and phenolacetic acid, and as preservatives and Bactericidal and disinfectant; used in the organic synthesis industry to manufacture bisphenol A, salicylic acid, picric acid, diphenyl ether, adipic acid and alkylphenols, etc. In recent years, with the rapid development of the global electronic communication industry, automobile industry and construction industry, the demand for phenolic resin and bisphenol A, the downstream products of phenol, has increased significantly, drivin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/343C07C69/606C07C69/618C07C67/333C07C69/757
CPCC07C67/333C07C67/343C07C69/606C07C69/618C07C69/757
Inventor 毛春艳胡奡凌想想胡益民
Owner 陕西巴斯腾科技有限公司
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