Preparation method for antibacterial peptide-containing dental implant of bioactive surface
A biologically active, dental implant technology, applied in prosthesis, pharmaceutical formula, tissue regeneration, etc., can solve the problems of implant loosening, loss, and surrounding bone tissue defects, achieving efficient sterilization and broad application prospects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0028] (1) The dental implant with the titanium dioxide nanotube array layer on the surface is ultrasonically cleaned with deionized water, ethanol and acetone in sequence, dried with nitrogen, placed in a vacuum drying oven, and dried at 60°C for 24 hours , put aside;
[0029] (2) Dissolving chitosan in 0.3% acetic acid solution to prepare a 0.5 mg / ml chitosan solution, the deacetylation degree of the chitosan is 50%, and the Mw is 1000 kDa.
[0030] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.1, and adding Span 80 with a volume concentration of 0.5%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 2:1, stirring at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;
[0031] (4) Add 1ml of cross-linking agent vanillin of 5mg / ml to the water-in-oil emulsion obtained in step (3), and react for 4 hours under stirring at 40° C. to obtai...
Embodiment 2
[0035] (1) The dental implant with the titanium dioxide nanotube array layer on the surface is ultrasonically cleaned with deionized water, ethanol and acetone in sequence, dried with nitrogen, placed in a vacuum drying oven, and dried at 60°C for 24 hours , put aside;
[0036] (2) dissolving chitosan in 3% acetic acid solution to prepare a 5mg / ml chitosan solution, the deacetylation degree of the chitosan is 98%, and the Mw is 1500kDa.
[0037] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.4, and adding Span 80 with a volume concentration of 1%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 4:1, and stirred at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;
[0038] (4) Add 10 mg / ml cross-linking agent vanillin 1 ml to the water-in-oil emulsion obtained in step (3), and react for 6 hours under stirring at 60° C. to obtain chitos...
Embodiment 3
[0042] The dental implant that step (1) is processed in embodiment 1 is immersed in the chitosan solution described in above embodiment 1 and 2 for 10~20min, so that the surface of the dental implant is positively charged; Deionized water is fully cleaned;
[0043] Submerge the above-mentioned cleaned dental implant in the above-mentioned 1 mg / ml AMP complex solution for 10-20 minutes, so that the surface of the dental implant is negatively charged; then fully wash it with deionized water;
[0044] The dental implant that is processed is immersed in the chitosan solution described in the above embodiments 1 and 2 for 10 to 20 minutes, so that the surface of the dental implant is positively charged; then fully cleaned with deionized water;
[0045] According to the number of layers to be assembled, the steps of Example 3 are repeated more than two times to obtain dental implants with different layers of coatings.
PUM
Property | Measurement | Unit |
---|---|---|
molecular weight | aaaaa | aaaaa |
degree of deacetylation | aaaaa | aaaaa |
degree of deacetylation | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com