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Low-swelling biodegradable medical photopolymeric aquagel and preparation method thereof

A biodegradable and photopolymerizable technology, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulations, drug delivery, etc., can solve the problems of low strength and large gel swelling ratio, and achieve low swelling ratio and low swelling rate , the effect of avoiding adverse consequences

Active Publication Date: 2017-03-29
南通药享科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to improve the problem of high swelling ratio and low strength of the gel prepared by linear polymer

Method used

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  • Low-swelling biodegradable medical photopolymeric aquagel and preparation method thereof
  • Low-swelling biodegradable medical photopolymeric aquagel and preparation method thereof
  • Low-swelling biodegradable medical photopolymeric aquagel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) Preparation of polyester modified six-arm polyethylene glycol block copolymer

[0060] Put 100g of six-armed polyethylene glycol (molecular weight: 6000) into a vacuum reaction flask, remove water under reduced pressure at 100°C for 2 hours, cool to room temperature, and equilibrate with dry nitrogen, add 11.40g of caprolactone and 0.3g of stannous octoate. After vacuum deoxygenation, the reaction was carried out at a vacuum degree of 10 Pa and a temperature of 115°C for 12 hours. The crude product was dissolved in 50 mL of anhydrous dichloromethane, precipitated with glacial ether, filtered, and vacuum-dried at room temperature to constant weight to obtain a polyester-modified six-arm poly Ethylene glycol block copolymer.

[0061] (2) Preparation of acrylate-terminated polyester modified six-arm polyethylene glycol

[0062] Dissolve 50g of polyester-modified six-arm polyethylene glycol and 4.54g of triethylamine in 30mL of anhydrous dichloromethane, cool down to 0...

Embodiment 2

[0066] (1) Preparation of polyester modified six-arm polyethylene glycol block copolymer

[0067] Put 150g of six-armed polyethylene glycol (molecular weight: 10000) into a vacuum reaction bottle, remove water under reduced pressure at 100°C for 2 hours, cool to room temperature, and equilibrate with dry nitrogen, add 20.52g of caprolactone and 0.4g of stannous octoate. After vacuum deoxygenation, react at a vacuum degree of 20 Pa and a temperature of 125°C for 12 hours. The crude product is dissolved in 80 mL of anhydrous dichloromethane, precipitated with glacial ether, filtered, and vacuum-dried at room temperature to constant weight to obtain a polyester-modified six-arm poly Ethylene glycol block copolymer.

[0068] (2) Preparation of acrylate-terminated polyester modified six-arm polyethylene glycol

[0069] Dissolve 50g of polyester-modified six-arm polyethylene glycol and 5.34g of triethylamine in 25mL of anhydrous dichloromethane, cool down to 0°C, and slowly add 4.7...

Embodiment 3

[0073] (1) Preparation of polyester modified six-arm polyethylene glycol block copolymer

[0074] Put 200g of six-armed polyethylene glycol (molecular weight: 15000) into a vacuum reaction bottle, remove water under reduced pressure at 100°C for 2 hours, cool to room temperature, and equilibrate with dry nitrogen, add 27.36g of caprolactone and 0.35g of stannous octoate. After vacuum deoxygenation, react at a vacuum degree of 10 Pa and a temperature of 135°C for 12 hours. The crude product is dissolved in 120 mL of anhydrous dichloromethane, precipitated with glacial ether, filtered, and vacuum-dried at room temperature to constant weight to obtain a polyester-modified six-arm poly Ethylene glycol block copolymer.

[0075] (2) Preparation of acrylate-terminated polyester modified six-arm polyethylene glycol

[0076] Dissolve 50g of polyester-modified six-arm polyethylene glycol and 3.56g of triethylamine in 25mL of anhydrous dichloromethane, cool down to 0°C, and slowly add 3...

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Abstract

The invention discloses a low-swelling biodegradable medical photopolymeric aquagel and a preparation method thereof. The preparation method comprises the following steps: (1) synthesizing a polyester-modified multi-arm polyethyleneglycol block copolymer; (2) preparing an acrylate-terminated polyester-modified multi-arm polyethyleneglycol polymer; and (3) carrying out polymerization under ultraviolet irradiation to generate the aquagel. The preparation method has the advantages of simple technique and accessible raw materials; and the polymerization can be initiated under the irradiation of ultraviolet light at normal temperature, so the method is pollution-free. The prepared aquagel has the advantages of favorable biocompatibility, higher rupture resistance and lower swelling ratio, and the degradation time can be adjusted by controlling the polyester content. The aquagel is more suitable for narrow parts of humans (organisms). The method has the advantages of simple steps and high practicality, and is convenient to operate.

Description

technical field [0001] The invention belongs to the field of biodegradable polymer materials, in particular to a low-swelling biodegradable medical photopolymerizable hydrogel and a preparation method thereof. Background technique [0002] Photopolymerizable hydrogel is a new type of polymer material. In addition to excellent photosensitivity and drug sustained release properties, it also has excellent properties such as safety, non-toxicity, environmental protection, and pollution-free. Therefore, it is widely used in medicine, tissue engineering and other fields. Has a wider range of applications. [0003] Polyester-modified polyethylene glycol has unique properties such as hydrophilicity, flexibility, non-toxicity, and biodegradability. Its hydrogel is electrically neutral or ionic, which swells in water and maintains a large amount of water without dissolving. Polymer materials have good biocompatibility, minimal inflammatory response, and blood coagulation, and have be...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/28C08G63/664C08G63/91A61K9/06A61K47/34C08L67/00
CPCA61K9/0002A61K9/06A61K47/34C08G63/664C08G63/912C08J3/075C08J3/28C08J2367/00
Inventor 侯昭升吴茹霞侯萍徐魏魏
Owner 南通药享科技有限公司
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