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Natural-blood-vessel-simulating three-layer artificial blood vessel stent and preparation method thereof

An artificial blood vessel, imitating nature technology, applied in non-woven fabrics, textiles, papermaking, medical science, etc., to achieve the effect of narrow fiber diameter distribution range, simple equipment, and uniform shape

Inactive Publication Date: 2017-03-29
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiency of existing artificial vascular stents, the present invention proposes a method for preparing a three-layer artificial vascular stent by electrospinning according to the three-layer structure of natural blood vessels and their synergistic effects. Through the method of sequential electrospinning, the present invention The invention successfully prepared a three-layer artificial vascular stent, which has good biocompatibility and good mechanical properties, and is expected to be applied in clinical use

Method used

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  • Natural-blood-vessel-simulating three-layer artificial blood vessel stent and preparation method thereof
  • Natural-blood-vessel-simulating three-layer artificial blood vessel stent and preparation method thereof
  • Natural-blood-vessel-simulating three-layer artificial blood vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The first step, polymer A is selected as polycaprolactone (PCL, (C 6 h 10 o 2 ) n ) and polylactic acid (PLA, (C 6 h 8 o 4 ) n ) is mixed in a mass ratio of 3:7 and dissolved in a mixed solvent, and is prepared into a spinning solution with a concentration of 10% by mass percentage, that is, a spinning solution of polymer A, for preparing the M layer; in the mixed solvent, acetone and The mass ratio of N,N-dimethylformamide w / w=1:5.

[0036] Polymer B is selected as dissolving PU-PCL (mass ratio 3:1) in a mixed solvent of DMF and THF to prepare a spinning solution of polymer B with a mass percentage of 10%, which is used to prepare the N layer. The mass ratio of DMF and THF in the mixed solvent is 3:1.

[0037] In the second step, the spinning solution of polymer A is placed in a syringe pump with a needle with a diameter of 0.8 mm, a voltage of 10-15 kV is applied, and electrospinning is carried out for 1 hour when the working distance is 10-15 cm. A rotating mo...

Embodiment 2

[0043] In the first step, polymer A is selected as polylactic acid (PLA, (C 6 h 8 o 4 ) n ), polymer A is dissolved in the mixed solvent, is formulated with the spinning solution of the polymer A of 15wt% concentration, is used to prepare M layer fiber film; In the mixed solvent, acetone and N,N-dimethylformamide The mass ratio w / w=1:1.

[0044] Polymer B is selected as pure polyurethane (PU, C 28 h 44 N 2 o 11 ), polymer B was dissolved in DMF and THF to make a spinning solution of 10% polymer B by mass percentage. Wherein, the mass ratio of DMF and THF is 1:3.

[0045] In the second step, the spinning solution of polymer A is placed in a syringe pump equipped with a needle with a diameter of 1.0mm, and a voltage of 15kV is applied to carry out electrospinning when the working distance is 15cm, and the rotational speed of the rotating motor for receiving fibers is 60r / min , to obtain an inner layer fiber membrane with excellent mechanical properties and a porosity of...

Embodiment 3

[0051] In the first step, the polymer A is selected as silk fibroin, and the polymer A is dissolved in ethanol to form a spinning solution of 8% by mass of the polymer A;

[0052] Polymer B is selected as polycaprolactone (PCL, (C 6 h 10 o 2 ) n ), a mixture of polylactic acid-glycolic acid copolymer (PLGA, 75:25), wherein the mass ratio of PCL to PLGA is 3:7. Polymer B was dissolved in a mixed solvent to prepare a spinning solution with 15% by mass of polymer B. The mass percentage w / w of acetone and N,N-dimethylformamide in the mixed solvent is 1:4.

[0053] In the second step, the spinning solution of polymer A is placed in a syringe pump equipped with a needle with a diameter of 1 mm, and a voltage of 10 kV is applied to perform electrospinning at a working distance of 15 cm. The spinning time is 0.5 h. The rotating motor of the tube collects the fibers to prepare the inner fibrous layer of the three-layer vascular stent. The rotational speed of the rotary motor is 6...

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Abstract

The invention discloses a natural-blood-vessel-simulating three-layer artificial blood vessel stent and a preparation method of the natural-blood-vessel-simulating three-layer artificial blood vessel stent, belonging to the field of tissue engineering. According to the natural-blood-vessel-simulating three-layer artificial blood vessel stent, a polymer material with good biocompatibility is taken as a precursor, after electrostatic spinning, the polymer material forms an inner layer and an outer layer, contacting the cells, of the three-layer artificial blood vessel, good biocompatibility is provided for the artificial blood vessel, a fibrous membrane with good mechanical property is prepared through the electrostatic spinning method, and the fibrous membrane serves as a middle mechanical support layer of the three-layer blood vessel. The prepared three-layer artificial blood vessel stent has good biocompatibility and strong mechanical property. The fibers forming the artificial blood vessel stent have smooth surface, uniform morphology and narrow fiber diameter distribution range, and in addition, the blood vessel is excellent in biological property and mechanical property, and is expected to be applied to the practical clinical diagnosis.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and specifically relates to a three-layer artificial vascular stent imitating natural blood vessels and a preparation method thereof. The composition of the three-layer artificial vascular stent is a three-layer structure of MNM, and the M layer is biocompatible The better material, the N layer provides the layer for mechanical properties. Background technique [0002] With the development of society, various vascular diseases have become the number one killer of human health, such as hemangioma, blood vessel damage, cardiovascular disease, atherosclerosis, etc. At present, the main method of treating vascular diseases is blood vessel transplantation. The best source of blood vessel transplantation is autologous, but autologous blood vessels are limited, so the demand for artificial blood vessels is increasing. Large-diameter artificial blood vessels have been used in clinical practice, but smal...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/22A61L27/50D04H1/728D01D5/00
CPCA61L27/18A61L27/22A61L27/507D01D5/0069D01D5/0092D04H1/728C08L67/04C08L75/04C08L89/00
Inventor 赵勇王女刘凯
Owner BEIHANG UNIV
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