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Orally administered agent for ruminants and ruminant feed containing same

A ruminant, oral technology, applied in the direction of animal feed, molding or processing of animal feed, medical preparations containing active ingredients, etc., can solve the problems of failure to check the breaking strength, difficulty in applying other substances, etc., and achieve reliable High processability and versatility, easy preparation effect

Active Publication Date: 2017-02-22
MORISHITA JINTAN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology is also only applied to fish oil, it is difficult to apply to other substances
In addition, the specific gravity and particle size of the composition are limited, but the breaking strength is not checked

Method used

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  • Orally administered agent for ruminants and ruminant feed containing same
  • Orally administered agent for ruminants and ruminant feed containing same
  • Orally administered agent for ruminants and ruminant feed containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103]High-density polyethylene (PE) (specific gravity 0.95), polymethyl methacrylate (PMMA) (specific gravity 1.19), polyoxymethylene (POM) (specific gravity 1.41) in each particle size of 4 mm, 6 mm, 8 mm and 12 mm and polytetrafluoroethylene (PTFE) (specific gravity 2.20) each one hundred commercially available beads were orally administered to 4 lactating cows. The cumulative rate of the number of beads in the intact state (which is excreted in feces) is described in Figure 1-Figure 5 . Figure 1-Figure 4 The cumulative excretion rates for beads of different types of resins, ie, for beads with different specific gravity at each diameter are shown. in addition, figure 1 Data for HDPE beads, figure 2 is the data for polymethylmethacrylate (PMMA) beads, image 3 data for polyoxymethylene (POM) beads, and Figure 4 Data for polytetrafluoroethylene (PTFE) beads. Figure 5 It is a comparison of 4 types of resins in beads with a particle size of 6 mm, ie comparative data...

Embodiment 2

[0107] Production of seamless capsules

[0108] 20 parts of thiamine hydrochloride (manufactured by Tokyo Kasei Kogyo Co., Ltd.) and 20 parts of titanium dioxide were dispersed in 60 parts of Melano H1000S (hydrogenated palm kernel oil produced by Fuji Oil Co., Ltd., which has a melting point of 34°C ( 32-36° C.)) to obtain a core formulation composition (dispersion for preparing cores).

[0109] 30 parts of titanium dioxide were dispersed in a warm solution of 70 parts of extremely hardened rice bran oil (melting point 53°C (52-54°C), Boso oiland fat Co., Ltd.) to obtain an inner shell membrane preparation composition comprising The oily substance of the inner shell membrane.

[0110] As the shell membrane composition for forming the shell membrane, 15 parts of carrageenan (manufactured by Sansho Co., Ltd.), 50.9 parts of dextrin (manufactured by Nippon Starch Chemical Co., Ltd.; DE value less than 10 ), 3 parts of sorbitol (manufactured by Mitsubishi Shoji Foodtech Co., Lt...

Embodiment 3-8 and comparative Embodiment 1-6

[0117] In Examples 3-8 and Comparative Examples 1-6, dry seamless capsules were obtained by the procedures described in Example 2, except that the composition ratios of the core, middle layer and shell film are as shown in Table 1 changes shown.

[0118] Table 1-1

[0119]

[0120] Table 1-2

[0121]

[0122] L-Ascorbic acid: Wako Pure Chemical Industries, Ltd.

[0123] Melano H1000: hydrogenated palm kernel oil obtained from Fuji Oil Co., Ltd., melting point 38°C (36-40°C)

[0124] Melano H3000: hydrogenated palm kernel oil obtained from Fuji Oil Co., Ltd., melting point 42°C (40-44°C)

[0125] Permel 45: middle melting fraction of palm distillate from Fuji oil Co., Ltd., melting point 45°C (43-47°C).

[0126] For each of the obtained dry seamless capsules, use isooctane as a specific gravity standard solution, based on the Archimedes method, measure the specific gravity of the seamless capsules by the following method:

[0127] Put 5 mL of isooctane in a 10 mL mea...

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Abstract

Provided is an orally administered agent that is for ruminants and that is not broken down in the rumen by avoiding breakdown resulting from the rumination of ruminants, passes into the lower alimentary tract, and is there broken down and dissolved. The present invention provides an orally administered agent that is for ruminants and of which the specific gravity is 1.17-2.00, the largest particle size and smallest particles size are both in the range of 4-10 mm, and the breaking strength of the smallest particle size portion in the body-temperature environment of ruminants is 0.5-5.0 N. The present invention further provides a method for orally administering a medicine to ruminants and a ruminant feed containing the orally administered agent.

Description

technical field [0001] The present invention relates to an orally administered agent for ruminants, specifically an orally administered agent that reaches the lower digestive tract by avoiding its destruction due to ruminant, and a feed for ruminants containing the orally administered agent. [0002] Background of the invention [0003] In the technical field of veterinary / animal husbandry, vitamin preparations and / or sugar preparations are administered as part of the prophylaxis and / or treatment of diseases in domesticated ruminants such as cattle. However, in cattle, for example, there are ten to one hundred billion microorganisms per 1 g of stomach contents in the rumen (one of four stomachs). Therefore, if vitamin B1 and / or sugar preparations such as commonly used in digestive disorder therapeutics and / or fast-acting nutritional supplements are orally administered, microorganisms decompose them, and these components cannot be efficiently absorbed in the body of cattle and...

Claims

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Application Information

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IPC IPC(8): A23K50/10A23K20/10
CPCA23K40/35A23K50/10A61K31/375A23K20/174A23K20/00A23K20/105A61J3/07A61K9/0056A61K9/4816A61K9/4833A61K9/485A61K9/4866A61K9/4875A61K31/51A61K35/747A61K2035/115
Inventor 足立卓彦濑山智博平康博章笠井浩司藤谷泰裕
Owner MORISHITA JINTAN CO LTD
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