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Method for preparing and using vascular stent

A vascular stent and heat-sensitive technology, applied in the field of preparation of vascular stents, can solve problems such as blocked capillaries in the brain, necrosis, and damage to limb functions, and achieve the effects of simple preparation methods, simple use methods, and convenient storage

Inactive Publication Date: 2017-02-01
福州维亚多国际贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent application CN 105771003A discloses a method for preparing biodegradable polymer self-expanding vascular stents based on 3D printing technology. The patent uses biodegradable polymers to prepare stents. Although the removal operation is eliminated, the degradation of vascular built-in materials Is uncontrollable and cannot guarantee uniform degradation of the implant as a whole
This will inevitably cause the degraded material to produce and peel off polymer fragments of different sizes during the degradation process
The size of these degradation products cannot be controlled. If some larger-sized fragments flow through the brain with the blood circulation, they will inevitably block the capillaries of the brain, which will cause damage to the limb function of the patient's brain area control area, and even cause brain damage. Severe conditions such as ischemia and necrosis

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  • Method for preparing and using vascular stent
  • Method for preparing and using vascular stent
  • Method for preparing and using vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 2.0g PEO (polyethylene oxide, molecular weight: 500-10,000 Daltons) and 0.32mL THDI (trimethylhexamethylene diisocyanate), in the presence of 30μL dibutyl tin dilaurate catalyst and nitrogen protection, React in dimethyl sulfoxide (DMSO) (20 mL) for one hour. The reaction temperature is maintained at 60-70°C. 4.7 mg (2% molar ratio) of cross-linked cinnamamide was dissolved in 1 mL of DMSO (dimethyl sulfoxide) and added to the reaction system. Continue stirring and keep the reaction temperature at 60-70°C for two hours. Finally, 22.7mg of MTX, namely methotrexate, with the chemical formula (2S)-2-[(4-{[(2,4-diaminopyridin-6-yl)methyl](methylamino}benzyl Acyl)amino]valeric acid, dissolve it in 2mL DMSO (dimethyl sulfoxide) and add it to the reaction system. Stir the mixture at 60-70°C for four hours, then stop heating. Let the reactants continue to stay at room temperature Stir overnight, react for 12 hours, and finally add 1 mL of methanol to terminate the polymerizat...

Embodiment 2

[0057] 2.0g PCL (polycaprolactone, molecular weight: 500-10,000 Daltons) and 0.32mL THDI (trimethylhexamethylene diisocyanate), in the presence of 30μL dibutyl tin dilaurate catalyst and under the protection of nitrogen, React in dimethyl sulfoxide (DMSO) (20 mL) for one hour. The reaction temperature is maintained at 60-70°C. 4.7 mg (2% molar ratio) of the cross-linking agent cinnamamide was dissolved in 1 mL of DMSO and then added to the reaction system. Continue stirring and keep the reaction temperature at 60-70°C for three hours. Finally, 22.7mg of MTX, namely methotrexate, with the chemical formula (2S)-2-[(4-{[(2,4-diaminopyridin-6-yl)methyl](methylamino}benzyl Acyl)amino]valeric acid, dissolve it in 2mL DMSO and add it to the reaction system. Stir the mixture at 60-70°C for five hours, then stop heating. Let the reactants continue to stir overnight at room temperature for 16 hours. Finally, 1 mL of methanol was added to terminate the polymerization reaction. The obta...

Embodiment 3

[0063] Dissolve 316 mg of glycine-leucine-lysine in 10 mL of THF (tetrahydrofuran), and add 2.5 molar equivalents of 2-chloroethanol. The mixture was heated to 50-60°C and continuously stirred for 6 hours, and then cooled to room temperature. The reaction mixture was washed with 5 mL of 1 M NaOH aqueous solution, and then extracted with dichloromethane. After removing the solvent, the diol derivative of the tripeptide was obtained with a yield of 60%.

[0064] The diol derivative of the obtained tripeptide and MTX (methotrexate, the chemical formula is (2S)-2-[(4-{[(2,4-diaminopyridin-6-yl)methyl]( Methylamino}benzoyl)amino]valeric acid) was dissolved in chloroform at a molar ratio of 1:1. 0.15 molar equivalent of dicyclohexylcarbimide (DCC) was added and stirred at room temperature for reaction for two hours. After the solvent is filtered and purified, the active drug, namely the tripeptide diol derivative of methotrexate, is obtained. The yield is> 90%.

[0065] Dissolve 1.9g ...

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Abstract

The invention relates to a method for preparing and using a vascular stent. A cardiovascular stent is prepared by using a self-made thermosensitive memory polymer and a 3D printing technology. The self-made thermosensitive memory polymer is a thermosensitive memory type polyurethane material with a molecular weight of 8000-200000 Dalton and a vitrification conversion temperature of 35-45 DEG C. The preparation method of the vascular stent is simple, the product can be controlled, the prepared thermosensitive memory type polyurethane material has the vitrification conversion temperature larger than the temperature of a body, and meets the use requirements; the use of the 3D printing technology can provide a customized vascular stent for a patient under the condition of a subfebrile temperature according to the needs of an operation, the use method is simple, and the storage is convenient.

Description

Technical field [0001] The invention relates to the preparation field of medical devices, in particular to a preparation and use method of a blood vessel stent Background technique [0002] Medical equipment has become an important field of modern medicine. The demand for medical products in China has grown higher than the global average. With a huge population base, a rapidly increasing aging population and people’s increasing health awareness, national policies, medical informatization and technological revolution, the market demand for medical products in China continues to grow rapidly. . However, once a medical device fails, even if it does not immediately constitute a safety issue, it will not be able to perform its basic functions. Therefore, medical device developers must not only plug design loopholes in the product conception stage, but also continuously throughout the product life cycle. To manage related risks to avoid equipment failure, this places high requirement...

Claims

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Application Information

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IPC IPC(8): C08G18/73C08G18/66C08G18/48C08G18/42C08G18/32C08G18/38A61L31/06A61L31/14A61L31/16B33Y10/00B33Y70/00B33Y80/00
CPCA61L31/06A61L31/14A61L31/16A61L2400/16B33Y10/00B33Y70/00B33Y80/00C08G18/10C08G18/4277C08G18/4833C08G18/73C08G2280/00C08L75/04C08G18/3844C08G18/3848
Inventor 陈汉杰弗兰克·拉隆德顾梵瞿国伟
Owner 福州维亚多国际贸易有限公司
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