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A kind of bioactive gynecological embolism and preparation method thereof

A bioactive and bioactive glass technology, applied in the field of biomedical materials, can solve problems such as unsatisfactory hemostasis, detachment of functional components, and poor therapeutic effect, and achieve the effect of promoting healing growth, promoting healing, and good biocompatibility

Active Publication Date: 2019-06-18
四川艾医生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve many problems in the prior art, such as detachment of functional components of gynecological embolism products, poor therapeutic effect, and unsatisfactory hemostasis after gynecological surgery, the purpose of the present invention is to provide a method that can effectively improve the clean environment of the vagina and treat vaginal inflammation and cervical cancer. Bioactive gynecological embolism for erosion and postoperative hemostasis and preparation method thereof

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  • A kind of bioactive gynecological embolism and preparation method thereof

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preparation example Construction

[0024] The preparation method of the bioactive plug of the present invention will be described in detail below.

[0025] According to an exemplary embodiment of the present invention, the preparation method of the bioactive gynecologic plug includes the following steps.

[0026] Step A:

[0027] In terms of mass percentage, 8-15% of chitosan derivatives, 3-10% of bioactive glass, 5-20% of pore-forming agent and the rest of water are uniformly mixed to obtain chitosan composite suspension.

[0028] Among them, bioactive glass exists in the form of powder, which has excellent surface activity, can promote the growth of growth factors, promote cell reproduction, and activate cell gene expression. It not only has a wide range of antibacterial effects, but also promotes soft tissue and Bone tissue grows and promotes wound healing. The bioglass synthesized in the prior art is mostly based on mesoporous bioglass, such as the mesoporous bioglass fiber material prepared by Chinese pa...

Embodiment 1

[0051] In terms of mass percentage, 8% of carboxymethyl chitosan, 3% of bioactive glass, 20% of ethanol pore-forming agent and the rest of water are uniformly mixed to obtain chitosan composite suspension. Among them, the molecular weight of carboxymethyl chitosan is 50,000, the particle size of bioactive glass is 20 μm, and its component is 44% SiO 2 , 5.5% P 2 o 5 , 25% Na 2 O, 23% CaO, 2% MgO and 0.5% Ag 2 O, the activated carbon fiber cloth is FCA type carbon fiber cloth with a thickness of 5mm and an adsorption capacity of 1000g / g.

[0052] After mixing, perform static negative pressure degassing at -0.1 MPa and stir with an ultrasonic disperser for 20 minutes to obtain a chitosan composite suspension.

[0053] Activated carbon fiber cloth is used as the base material and an external voltage is applied to the base material to form an electrostatic field between the base material and the high-pressure nozzle. material, then cured and dried to form a bioactive composit...

Embodiment 2

[0056] In terms of mass percentage, 10% of carboxymethyl chitosan iodine, 6% of bioactive glass, 15% of ethanol pore-forming agent and the rest of water are uniformly mixed to obtain chitosan composite suspension. Among them, the molecular weight of carboxymethyl chitosan is 50,000, the particle size of bioactive glass is 20 μm, and its component is 44% SiO 2 , 5.5% P 2 o 5 , 25% Na 2 O, 23% CaO, 2% MgO and 0.5% Ag 2 O, the activated carbon fiber cloth is FCA type carbon fiber cloth with a thickness of 5mm and an adsorption capacity of 1000g / g.

[0057] After mixing, perform static negative pressure degassing at -0.1 MPa and stir with an ultrasonic disperser for 20 minutes to obtain a chitosan composite suspension.

[0058] Activated carbon fiber cloth is used as the base material and an external voltage is applied to the base material to form an electrostatic field between the base material and the high-pressure nozzle. material, then cured and dried to form a bioactive ...

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Abstract

The invention discloses a bioactive gynecologic suppository and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing the following components in percentage by mass: 8 percent to 15 percent of a chitosan derivative, 3 percent to 10 percent of bioactive glass, 5 percent to 20 percent of a pore-forming agent and the balance of water, so as to obtain a chitosan compound suspension mixed solution; taking active carbon fiber cloth as a base material and applying voltage to the base material to form a static electric field between the base material and a high-pressure nozzle; spraying the chitosan compound suspension mixed solution on double faces of the base material by the high-pressure nozzle in a high-pressure atomization and spraying manner; then curing and drying to form a bioactive composite material; cutting and slicing the bioactive composite material and rolling to form a bioactive composite roll; sealing and packaging, and sterilizing to obtain the bioactive gynecologic suppository. By adopting a preparation technology combining electrostatic adsorption and high-pressure spraying, the bioactive gynecologic suppository, which has effects of stopping bleeding and promoting better healing and therapeutic effects and can improve the use feeling of patients, is prepared.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, and more specifically relates to a bioactive gynecological embolism for improving vaginal clean environment, treating vaginal inflammation, cervical erosion and postoperative hemostasis and a preparation method thereof. Background technique [0002] Cervical erosion is one of the most common diseases in gynecology. Its incidence rate is high and it is the main factor that causes cervical cancer. There are many reasons for the occurrence of cervical erosion. Foreign body oozes out, and there are symptoms such as bleeding and pain at the same time. [0003] At present, there are many methods for treating cervical erosion, such as microwave laser, LEEP, freezing and drug therapy, etc., which have been used clinically for many years, and the effect is also good. However, after the above methods of treatment (especially after cervical tissue biopsy, LEEP knife and cervical conization), p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61L24/08A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/08A61L2300/102A61L2300/232A61L2300/412A61L2300/42A61L2300/602A61L2400/04C08L5/08
Inventor 高海利
Owner 四川艾医生医疗科技有限公司
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