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Extracellular matrix imitated eye drops and preparation method thereof

A technology of eye drops and extracellular matrix, which is applied in the field of medicine, can solve the problems of interfering with the normal metabolism of corneal epithelium, reducing the clinical curative effect, aggravating the disease, etc., and achieves the effect of prolonging the drug action time, simple preparation method, and high-efficiency drug use

Inactive Publication Date: 2016-10-12
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, due to the increase of corneal trauma, coupled with the wide clinical application of broad-spectrum antibiotics and corticosteroids and the increase in the use of contact lenses, the incidence of keratitis is also increasing year by year. The current common treatment method is the use of antibiotics. Eye drops, including chloramphenicol eye drops, erythromycin eye drops and the fourth-generation quinolone eye drops represented by levofloxacin, but the consequences of misuse of antibiotic eye drops are very serious, first of all, the drug resistance of pathogenic bacteria increases , the clinical curative effect is reduced, causing the disease to be cured for a long time. Secondly, the antibiotic itself and its auxiliary components will affect the normal physiological environment of the eye to a certain extent, interfere with the normal metabolism of the corneal epithelium, and even aggravate the original condition, so it cannot be used for a long time

Method used

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  • Extracellular matrix imitated eye drops and preparation method thereof
  • Extracellular matrix imitated eye drops and preparation method thereof
  • Extracellular matrix imitated eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Eye drop formula

[0033]An eye drop imitating extracellular matrix, which comprises the following components in parts by weight: 8 parts of Lifitegrast, 2 parts of heparan sulfate of 0.5mg / ml, 6 parts of sodium hyaluronate of 150wDa, 0.06 parts of growth factor of 10000IU / ml, 0.5 parts of collagen and 300 parts of water for injection.

[0034] The pH of the eye drops is 7.5, which is adjusted by boric acid buffer.

[0035] The osmotic pressure of the eye drops is 300mOsm / L, adjusted by sodium chloride and potassium chloride, the mass concentration of sodium chloride is 0.5%, and the mass concentration of potassium chloride is 0.1%.

[0036] Heparan sulfate is extracted from natural ingredients or produced by bacterial fermentation; sodium hyaluronate is produced by cockscomb extraction or fermentation.

[0037] The growth factor is prepared by using epidermal growth factor: fibroblast growth factor: basic fibroblast growth factor: placenta growth factor according ...

Embodiment 2

[0044] 1. Eye drop formula

[0045] An eye drop imitating extracellular matrix, which comprises the following components in parts by weight: 5 parts of Lifitegrast, 0.1 part of heparan sulfate of 30mg / ml, 4 parts of sodium hyaluronate of 40wDa, 0.1 part of growth factor of 4000IU / ml, collagen 0.1 part of protein and 200 parts of water for injection.

[0046] The pH of the eye drops is 5.5, adjusted with phosphate buffer.

[0047] The osmotic pressure of the eye drops is 350mOsm / L, adjusted by sodium chloride, and the mass concentration of sodium chloride is 0.3%.

[0048] Heparan sulfate is extracted from natural ingredients or produced by bacterial fermentation; sodium hyaluronate is produced by cockscomb extraction or fermentation.

[0049] The growth factor is prepared by using epidermal growth factor: fibroblast growth factor: basic fibroblast according to the weight ratio of 1:3:1.

[0050] 2. Preparation method of eye drops

[0051] (1) First take by weighing the sod...

Embodiment 3

[0056] 1. Eye drop formula

[0057] An eye drop imitating extracellular matrix, which comprises the following components in parts by weight: 10 parts of Lifitegrast, 3 parts of heparan sulfate of 30mg / ml, 1 part of sodium hyaluronate of 100wDa, 0.01 part of growth factor of 5000IU / ml, collagen 1 part protein and 500 parts water for injection.

[0058] The pH of the eye drops is 6, which is adjusted by phosphate buffer and boric acid buffer.

[0059] The osmotic pressure of the eye drops is 280mOsm / L, adjusted by potassium chloride, and the mass concentration of potassium chloride is 0.1%.

[0060] Heparan sulfate is extracted from natural ingredients or produced by bacterial fermentation; sodium hyaluronate is produced by cockscomb extraction or fermentation.

[0061] The growth factor is prepared by using epidermal growth factor: basic fibroblast growth factor: placental growth factor according to the weight ratio of 1:4:3.

[0062] 2. Preparation method of eye drops

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to extracellular matrix imitated eye drops and a preparation method thereof. Particularly, the eye drops are prepared from the following components in parts by weight: 1-20 parts of Lifitegrast, 0.1-5 parts of heparan sulfate, 1-10 parts of sodium hyaluronate, 0.01-0.1 part of growth factors, 0.1-1 part of collagen and 200-500 parts of water. Once conea is injured, the extracellular matrix imitated eye drops prepared by the invention can repair the cell communication channel of the conea by adjusting a biological function of an extracellular matrix, so that the physiological function of the conea is adjusted and repaired.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an extracellular matrix imitation eye drop and a preparation method thereof. Background technique [0002] The extracellular matrix (ECM) is a macromolecule synthesized and secreted by animal cells, distributed on the cell surface or between cells, mainly some polysaccharides and proteins, or proteoglycans. These substances form a complex network structure, support and connect tissue structures, regulate the occurrence of tissues and the physiological activities of cells. The extracellular matrix is ​​a part of animal tissue that does not belong to any cells. It determines the characteristics of connective tissue, provides a suitable place for the survival and activity of cells, and affects the shape, metabolism, function, migration, proliferation and differentiation of cells through the signal transduction system. The extracellular matrix not only statically suppo...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/08A61P27/02A61K31/4709A61K31/727A61K31/728A61K38/18
CPCA61K31/4709A61K9/0048A61K9/08A61K31/727A61K31/728A61K38/18A61K38/1808A61K38/1825A61K38/39A61K47/02A61K2300/00
Inventor 周晓惠张军东陈晚华廉云飞吴剑英
Owner 上海建华精细生物制品有限公司
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