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Wild chrysanthemum total flavonoid bio-adhesive double-layer patch for treating oral ulcer

An oral ulcer and bioadhesion technology, applied in the medical field, can solve problems such as oral flora imbalance, and achieve the effects of improving compliance, prolonging drug action time, and shortening the course of treatment.

Active Publication Date: 2013-01-23
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned preparations have more or less certain limitations. For example, metronidazole and ofloxacin belong to antibacterial drugs. For patients with recurrent oral ulcers, long-term repeated medication may easily cause oral flora imbalance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The present invention is composed of an adhesive layer and a protective layer, wherein the adhesive layer is made of 10g of total flavonoids of chrysanthemum flower, 10g of carbomer 934P, 20g of hydroxypropyl cellulose and 2g of lactose, and the protective layer is made of 8g of ethyl cellulose , when preparing, take the total flavonoids of wild chrysanthemum and add lactose, after mixing evenly, add carbomer 934P and hydroxypropyl cellulose, after mixing, pass through an 80-mesh sieve, press into a sheet-like adhesive layer, and then put it on the adhesive layer Repress ethyl cellulose again to form a composite double-layer patch with a diameter of 6mm, a thickness of 1.2mm, and a weight of 50mg; The mass concentration of the amount is 50% ethanol reflux extraction twice, each time 1 hour, merge twice extracting solution, filter, get filtrate centrifugation, obtain supernatant, after the supernatant is filtered with 0.1 μm ceramic membrane, obtain medicinal liquid , an...

Embodiment 2

[0012] The present invention is composed of an adhesive layer and a protective layer, wherein the adhesive layer is made of 5g of total flavonoids of chrysanthemum flower, 5g of carbomer 934P, 10g of hydroxypropyl cellulose and 1g of lactose, and the protective layer is made of 4g of ethyl cellulose , when preparing, take the total flavonoids of wild chrysanthemum and add lactose, after mixing evenly, add carbomer 934P and hydroxypropyl cellulose, after mixing, pass through a 60-mesh sieve, press into a sheet-like adhesive layer, and then put it on the adhesive layer Repress ethyl cellulose again to form a composite double-layer patch, with a diameter of 6mm, a thickness of 1.2mm, and a weight of 50mg; The mass concentration of the amount is 50% ethanol reflux extraction twice, each 40 minutes, merge twice extracting solution, filter, get filtrate centrifugation, obtain supernatant, after the supernatant is filtered with 0.1 μm ceramic membrane, obtain medicinal liquid , and t...

Embodiment 3

[0014] The present invention can also be composed of an adhesive layer and a protective layer, wherein the adhesive layer is made of 15g of total flavonoids of chrysanthemum flower, 15g of carbomer 934P, 30g of hydroxypropyl cellulose and 3g of lactose, and the protective layer is made of 12g of ethyl cellulose Composition, when preparing, take the total flavonoids of wild chrysanthemum flower and add lactose, mix well, add carbomer 934P and hydroxypropyl cellulose, mix well, pass through a 100-mesh sieve, press into a sheet-like adhesive layer, and then apply it to the adhesive layer Then press ethyl cellulose to form a composite double-layer patch, with a diameter of 6mm, a thickness of 1.2mm, and a weight of 50mg; The mass concentration of double amount is that 50% ethanol reflux extracts twice, each time 1 hour 30 minutes, merge twice extracting solution, filter, get filtrate centrifugation, obtain supernatant, after supernatant is filtered with 0.1 μm ceramic membrane, Th...

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Abstract

The invention relates to a wild chrysanthemum total flavonoid bio-adhesive double-layer patch for treating oral ulcer, which can effectively solve the therapeutic medication problem of oral ulcer; the patch is prepared by combining an adhesive layer with a protective layer, wherein the adhesive layer is prepared by 5-15 g of wild chrysanthemum total flavonoids, 5-15 g of carbomer 934P, 10-30 g ofhydroxy propyl cellulose, and 1-3 g of lactose, and the protective layer is prepared by 4-12 g of ethyl cellulose; the preparation method comprises the following steps: adding lactose into wild chrysanthemum total flavonoids, well mixing, adding carbomer 934P and hydroxy propyl cellulose, well mixing, sieving, pressing into a sheet-like adhesive layer, pressing ethyl cellulose on the adhesive layer to form the composite double-layer patch; the invention prolongs the action time of the drugs, greatly improves the curative effect, shortens the treatment course, reduces the administration frequency, increases patient compliance; the patch covers and adheres to a ulcer surface for longer time than pellicles, has protection effect on wound, and can reduce patient pain.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a bioadhesive double-layer patch of total flavonoids of wild chrysanthemum for treating oral ulcers. Background technique [0002] Recurrent oral ulcer is common disease, frequently-occurring disease, belongs to one of stomatological intractable diseases, and prevalence rate is as high as 25%. Modern medicine believes that its etiology is related to low immune function, bacterial and viral infections, endocrine disorders, autonomic nervous function and digestive tract dysfunction. Traditional Chinese medicine believes that the disease is related to excess heat in the spleen and stomach, inflammation of the heart fire, internal heat due to yin deficiency, internal dampness and heat, mixed with yin deficiency and dampness, which causes burns to the blood and corrodes the sarcolemma, or is caused by deficiency of spleen and kidney yang, deficiency of spleen and stomach qi, and mixed cold and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61K9/70A61P1/02
Inventor 段晓颖王林王彦志闫艳仓张辉王丽萍孙广科周婕
Owner HENAN UNIV OF CHINESE MEDICINE
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