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TTX (Tetrodotoxin) cod-liver oil emulsion

A technology of cod liver oil emulsion and cod liver oil, applied in the directions of anti-inflammatory agent, emulsion delivery, non-central analgesic, etc., can solve the problem that the mechanism of action needs to be further studied, and achieve the effect of drug safety, reducing toxicity and lasting drug effect

Inactive Publication Date: 2017-09-01
黄海枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of action remains to be further studied

Method used

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  • TTX (Tetrodotoxin) cod-liver oil emulsion
  • TTX (Tetrodotoxin) cod-liver oil emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of TTX solution: TTX citrate was dissolved in distilled water to prepare a solution with a TTX content of 10 μg / ml at pH 4-7.

[0036] Take 125g of gum arabic and 500ml of cod liver oil, grind well, add 250ml of TTX solution (containing TTX 10μg / ml), grind to make colostrum, add 1ml of aqueous solution containing 0.1g of saccharin sodium, 1ml of almond oil, stir well, and then slowly add western Take 7 g of tragacanth gum, stir it with a high-speed mixer, add distilled water to make 1000 ml, and stir well to obtain a TTX cod liver oil emulsion with a TTX content of 0.01 μg / ml.

Embodiment 2

[0038] Preparation of TTX solution: TTX citrate was dissolved in distilled water to prepare a solution with a pH of 4-7 and a TTX content of 0.5 mg / ml.

[0039] Take 125g of gum arabic and 500ml of cod liver oil, grind well, add 250ml of TTX solution (containing TTX 0.5mg / ml), grind to make colostrum, add 1ml of aqueous solution containing 0.1g of saccharin sodium, 1ml of almond oil, stir well, and then slowly add Gum tragacanth 7g, stirred by a high-speed mixer, added distilled water to make 1000ml, and stirred evenly to obtain a TTX cod liver oil emulsion with a TTX content of 0.5 μg / ml.

Embodiment 3

[0041] Preparation of TTX solution: TTX citrate was dissolved in distilled water to prepare a TTX solution with a pH value of 4-7 and a TTX content of 0.8 mg / ml.

[0042] Take 50g of gum arabic and 200ml of cod-liver oil, grind them evenly, add 100ml of distilled water once, grind, add 25ml of TTX solution (including TTX o, 8mg), grind to make colostrum, add 1ml of aqueous solution containing 0.04g of saccharin sodium, 0.4ml of almond oil, Stir well, then slowly add tragacanth mucilage 3.og, stir through a high-speed mixer, add distilled water to 400ml, stir well, and obtain TTX cod liver oil emulsion with a TTX content of 2 μg / ml.

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Abstract

The invention relates to pharmaceutical preparations, and in particular discloses TTX (Tetrodotoxin) cod-liver oil emulsion. The TTX cod-liver oil emulsion takes TTX and cod-liver oil as main drugs, wherein the effective content of the TTX is 0.01mu g / ml to 15mu g / ml. The TTX and the cod-liver oil which are proved to have no analgesic effect by pharmacological experiments, are used as the main drugs and are mixed with an emulsifier, auxiliary materials and the like to prepare the TTX cod-liver oil emulsion; animal experiments and clinical observation show that the obtained TTX cod-liver oil emulsion has a remarkable analgesic effect (P is less than 0.01). Moreover, in the emulsion provided by the invention, the TTX takes the cod-liver oil as a carrier, so that the TTX easily penetrates through a blood-cerebral barrier; the selectivity is high, and the targeting ability is strong, so that the dosage of the TTX can be reduced and the toxicity is reduced; the TTX is slowly absorbed and has a lasting pharmacological effect; the safe and efficient drug utilization is ensured.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a TTX cod liver oil emulsion. Background technique [0002] TTX (tetrodotoxin, tetrodotoxin) is a highly toxic active substance extracted from puffer fish viscera, and is one of the most toxic non-protein substances found in nature so far. Although this dreadful toxin can kill people, it has a novel chemical structure and unique pharmacological effects, and it can specifically block the nerve cell membrane Na + The channel has become an irreplaceable tool drug for neurobiology and physiology research. Clinically, it has the effects of analgesia and withdrawal of drug dependence. [0003] After the crude toxin was extracted by the Japanese scholar Tahara Yoshin in 1909, the clinical application of TTX came into being, and research papers on medicinal development emerged in endlessly. From the 1930s to the 1940s, many research reports aimed at the development of medicines were publ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K35/60A61P25/36A61P29/00A61K31/529
CPCA61K9/107A61K31/529A61K35/60A61K2300/00
Inventor 黄海枫冯子龙范奕辉黄致强
Owner 黄海枫
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