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A kind of freeze-dried product of canine interferon

A technology of canine interferon and freeze-dried products, applied in the field of canine interferon freeze-dried products, can solve the problems of difficulty in interferon storage and transportation, loss of canine interferon activity, low indicators of freeze-dried products, etc. The effect of drying efficiency, shortening lyophilization time, improving biological activity and product yield

Active Publication Date: 2019-05-14
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of product can effectively prolong the storage time of interferon protein, but its thermal stability is poor, and it needs to be stored below -15°C, which brings great difficulties to the storage and transportation of interferon; at the same time, freezing during large-scale production In the drying process, often due to long freeze-drying time or insufficient freeze-drying, the activity of canine interferon is lost or the indicators of freeze-dried products are low or even unqualified

Method used

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  • A kind of freeze-dried product of canine interferon
  • A kind of freeze-dried product of canine interferon
  • A kind of freeze-dried product of canine interferon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare the canine interferon freeze-dried product according to the following method, and its characteristics include the following preparation process:

[0021] According to dodecacrystalline water sodium hydrogen phosphate 2.9g / L, sodium dihydrogen phosphate 0.2g / L, polyvinylpyrrolidone 50g / L, mannitol 20g / L, soybean peptone 2.5g / L, tert-butanol 1.8g / L preparation To freeze-dry the stock solution, prepare the formula stock solution, autoclave it, and mix thoroughly; take some canine interferon stock solution, mix the autoclaved formula stock solution and canine interferon stock solution according to the ratio of 5:1, divide Pack it, add a rubber stopper cover, and put it into a freeze dryer for freeze drying; after the freeze drying is completed, press the cover to obtain the canine interferon freeze-dried product.

Embodiment 2

[0023] Prepare the canine interferon freeze-dried product according to the following method, and its characteristics include the following preparation process:

[0024] According to dodecacrystalline water sodium hydrogen phosphate 16.07g / L, sodium dihydrogen phosphate 1.05g / L, polyvinylpyrrolidone 125g / L, mannitol 50g / L, soybean peptone 1.5g / L, tert-butanol 2.25g / L To freeze-dry the stock solution, prepare the formula stock solution, autoclave it, and mix thoroughly; take some canine interferon stock solution, mix the autoclaved formula stock solution and canine interferon stock solution according to the ratio of 5:1, divide Pack it, add a rubber stopper cover, and put it into a freeze dryer for freeze drying; after the freeze drying is completed, press the cover to obtain the canine interferon freeze-dried product.

Embodiment 3

[0026] Prepare the canine interferon freeze-dried product according to the following method, and its characteristics include the following preparation process:

[0027] According to dodecacrystalline water sodium hydrogen phosphate 29.85g / L, sodium dihydrogen phosphate 1.98g / L, polyvinylpyrrolidone 200g / L, mannitol 80g / L, soybean peptone 0.5g / L, tert-butanol 2.7g / L To freeze-dry the stock solution, prepare the formula stock solution, autoclave it, and mix thoroughly; take some canine interferon stock solution, mix the autoclaved formula stock solution and canine interferon stock solution according to the ratio of 5:1, divide Pack it, add a rubber stopper cover, and put it into a freeze dryer for freeze drying; after the freeze drying is completed, press the cover to obtain the canine interferon freeze-dried product.

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Abstract

The invention discloses a dog interferon freeze-dried product, and relates to the technical field of freeze-dried biological products.The dog interferon freeze-dried product is prepared by freeze-drying a dog interferon stock solution and a freeze-drying protecting agent, wherein a freeze-drying protecting agent base solution is composed of a pH buffer agent and a protein protecting agent, and the freeze-drying protecting agent comprises a heat-resisting protective agent, a filling agent and a freeze-drying accelerating agent.The prepared dog interferon freeze-dried product can be stored for a long term at 2 DEG C-8 DEG C; due to the fact that the freeze-drying accelerating agent is added, the freeze-drying time of a freeze-drying technological link in large-scale industrialized production is shortened, the freeze-drying efficiency is improved, it is guaranteed that freeze-drying is full, and the stability of products of different batches is guaranteed; through combination of the preferable heat-resisting protective agent and filling agent, the anti-fracture strength of a dog interferon protein chain is improved, the biological activity of the dog interferon freeze-dried product is improved, and the product yield ratio of the dog interferon freeze-dried product is increased.

Description

technical field [0001] The invention relates to the technical field of freeze-dried biological products, in particular to a freeze-dried product of canine interferon. Background technique [0002] Canine interferon is a glycoprotein substance produced by normal canine body cells under the action of a suitable inducer. It has broad-spectrum anti-virus, anti-tumor and immune function regulation functions. It has been used clinically. The common clinical preparation is canine interferon lyophilized product, which is a biological product obtained by mixing canine interferon protein and lyoprotectant in proportion and then freeze-drying. This type of product can effectively prolong the storage time of interferon protein, but its thermal stability is poor, and it needs to be stored below -15°C, which brings great difficulties to the storage and transportation of interferon; at the same time, freezing during large-scale production In the drying process, often due to the long freez...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/555A61K38/21A61K9/19A61K47/10A61P31/12A61P35/00A61P37/04
CPCA61K9/19A61K38/21A61K47/10C07K14/555
Inventor 孙晨苏建东杨保收付旭彬梁武李守军
Owner TIANJIN RINGPU BIO TECH
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