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Compound preparation for treating endometrial hyperplasia and preparation method of compound preparation for treating endometrial hyperplasia

A technology for endometrial hyperplasia and compound preparations, applied in biochemical equipment and methods, medical preparations containing active ingredients, pill delivery, etc.

Inactive Publication Date: 2016-07-20
张金凤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past ten years, although the traumatic operations that destroy the endometrium, such as hysteroscopic-guided transcervical endometrial ablation and microwave irradiation endometrial ablation, have been widely used in the treatment of menorrhagia and endometrial hyperplasia, However, there are certain complications (including uterine perforation, water intoxication, bleeding and genital burns) and recurrence rate (11%-40%), and the operation has not fundamentally corrected the excessive estrogen in patients with endometrial hyperplasia. Endocrine conditions with excess and progesterone deficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: This example prepares a compound tablet for the treatment of endometrial hyperplasia, including the following ingredients in parts by weight: 11 parts of clomiphene citrate, 9 parts of medroxyprogesterone acetate, 3 parts of gossypol acetate 5 parts of L-carnitine, 20 parts of mannan peptide, 2 parts of estradiol valerate, 0.3 parts of preservative, 121 parts of filler, 4 parts of disintegrant, 6 parts of wetting agent, 3 parts of surfactant .

[0016] Wherein, the gossypol acetate is a yellow polyphenol hydroxyl bis-naphthaldehyde compound extracted from the roots, stems, leaves and seeds of the mallow plant cotton. The specific extraction process is as follows: crush the cotton kernels through a 100-mesh sieve, then add an acetone solution with a mass concentration of 80% to extract gossypol, and then use aniline as a solvent to back-extract the above extract, and free gossypol and aniline generate aniline gossypol , stand still until the aniline gossypol ...

Embodiment 2

[0021] Example 2: This example prepares a compound tablet for treating endometrial hyperplasia, including the following ingredients in parts by weight: 13.5 parts of clomiphene citrate, 12 parts of medroxyprogesterone acetate, 6 parts of gossypol acetate 8.5 parts of L-carnitine, 24 parts of mannan peptides, 3 parts of estradiol valerate, 0.5 parts of preservatives, 154 parts of fillers, 5.5 parts of disintegrants, 8 parts of wetting agents, and 5 parts of surfactants .

[0022] Wherein, the gossypol acetate is a yellow polyphenol hydroxyl bis-naphthaldehyde compound extracted from the roots, stems, leaves and seeds of the mallow plant cotton. The specific extraction process is as follows: crush the cotton kernels through a 100-mesh sieve, then add an acetone solution with a mass concentration of 80% to extract gossypol, and then use aniline as a solvent to back-extract the above extract, and free gossypol and aniline generate aniline gossypol , stand still until the aniline ...

Embodiment 3

[0027] Example 3: This example prepares a compound tablet for treating endometrial hyperplasia, including the following ingredients in parts by weight: 16 parts of clomiphene citrate, 15 parts of medroxyprogesterone acetate, and 9 parts of gossypol acetate 12 parts of L-carnitine, 28 parts of mannan peptide, 4 parts of estradiol valerate, 0.7 parts of preservative, 187 parts of filler, 7 parts of disintegrant, 10 parts of wetting agent, 7 parts of surfactant .

[0028] Wherein, the gossypol acetate is a yellow polyphenol hydroxyl bis-naphthaldehyde compound extracted from the roots, stems, leaves and seeds of the mallow plant cotton. The specific extraction process is as follows: crush the cotton kernels through a 100-mesh sieve, then add an acetone solution with a mass concentration of 80% to extract gossypol, and then use aniline as a solvent to back-extract the above extract, and free gossypol and aniline generate aniline gossypol , stand still until the aniline gossypol c...

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Abstract

The invention discloses a compound preparation for treating endometrial hyperplasia and a preparation method of the compound preparation for treating endometrial hyperplasia. The compound preparation comprises clomifene citrate, chorionic gonadotropin, medroxyprogesterone acetate, gossypol acetate, L-carnitine, estradiol dehydrogenase, amlodipine L-aspartic acid, clomifene, thymopentin, mannatide, levofloxacin hydrochloride, estradiol valerate, threonine and zinc gluconate. The compound preparation is capable of not only fighting bacteria, diminishing inflammation, promoting ovulation and protecting endometrial but also decreasing possibility of endometrial hyperplasia caused by obesity, high blood pressure and the like of women. It is clinically proven that the compound preparation has the advantages of remarkable effect in treatment of endometrial hyperplasia, capability of treating both symptoms and root causes and little toxic or side effect and is promising in application prospect.

Description

technical field [0001] The invention relates to the technical field of gynecological drugs, in particular to a compound preparation for treating endometrial hyperplasia and a preparation method thereof. Background technique [0002] Endometrial hyperplasia has a certain tendency to become cancerous, so it is listed as a precancerous lesion. But according to long-term observation, the vast majority of endometrial hyperplasia is a reversible lesion, or maintain a persistent benign state. Only a small number of cases may develop into carcinoma after a longer time interval. Menstrual disorders are one of the prominent symptoms of this disease, often manifested as irregular vaginal bleeding, thin menstruation, amenorrhea or bleeding after a period of amenorrhea. Commonly referred to as anovulatory blood. In addition to vaginal bleeding, infertility is also the main symptom of anovulatory DUB patients during reproductive period. There are three types of endometrial hyperplasia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K38/16A61P15/00A61K31/135A61K31/11A61K31/198A61K31/205A61K31/315A61K31/4422A61K31/5383A61K31/565A61K31/57A61K38/24A61K38/08
CPCA61K9/2059A61K31/11A61K31/135A61K31/198A61K31/205A61K31/315A61K31/4422A61K31/5383A61K31/565A61K31/57A61K38/08A61K38/16A61K38/24A61K38/443C12Y101/01062A61K2300/00
Inventor 张金凤
Owner 张金凤
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