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Pharmaceutical composition for treating lacunar infarction and preparation method thereof

A composition and technology for cerebral infarction, applied in the directions of drug combination, medical formula, drug delivery, etc., can solve the problems of slurred speech, inaccurate pronunciation of words and intonation, unfavorable treatment, etc., to improve microcirculation and shorten the course of treatment. , the effect of relieving cerebral edema

Inactive Publication Date: 2016-06-08
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Simple dysarthria type: All have mild language impairment, manifested as ambiguous speech, inaccurate pronunciation and intonation, but no phonemic errors, and can be completely understood. Some patients have poor sense of sound and slow speech
6. Vascular dilation: It is generally believed that the effect of vasodilators is uncertain. For severe patients with increased intracranial pressure, sometimes it can aggravate the condition, so it is not recommended to use it in the early stage
While treating cerebral infarction, western medicine has certain side effects on the liver, kidney, digestive tract and nervous system; moreover, many western medicines, including aspirin, are drug-resistant, because western medicine cannot deal with multiple links for the complicated etiology of cerebral infarction. Treatment, its pharmacological effect is reflected in a chemical molecular formula, which means that a molecular formula can only prevent and treat one link, and the long-term effect is poor
Therefore, western medicine treatment of cerebral infarction is not suitable for long-term use in the recovery period and sequelae period; moreover, western medicine treatment is not conducive to the treatment, and it often has dependence and side effects.

Method used

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Effect test

preparation example Construction

[0072] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0073] The first step is to mix the raw medicinal materials according to the stated ratio, add ethanol whose alcohol concentration is 85% to 95% relative to the mixture 4 to 8 times, heat to boiling and reflux for 3 to 5 hours, filter, and use the percolation method Slowly percolate at a rate of 1-2ml per minute, collect the percolation liquid, then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C, spray dry, spray The air inlet temperature of the dryer is 160-175°C, and the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0074] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obtain granules.

[0075] When the dos...

Embodiment 1

[0087] Embodiment 1 Granules

[0088] The preparation process of the granule of the present invention is as follows: get 160g of red cohosh, 320g of the upper leaves of the fruit, 200g of curcuma, 310g of piercing stone, 160g of stomach friend, 300g of lily, 240g of brassica seed, 300g of licorice, 150g of bougainvillea, 320g of mustard seed, 180g of musk, 240g of Eucommia, 180g of tangerine, 200g of black plum, 250g of melon wood, 320g of dense flower tree, 200g of loofah, 280g of rubbing white leaves, 120g of Sanqi, 320g of dandelion, 220g of Polygonum sagittata, 150g of horizontal sutra mat, and grinding disc 320g grass, 220g sarsaparilla, 170g safflower and 140g seaweed;

[0089] The first step is to mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a speed of 1.5ml per minute. Slowly percolate...

Embodiment 2

[0091] Embodiment 2 oral liquid

[0092] The preparation process of the oral liquid of the present invention is as follows: get 150g of red cohosh, 330g of the upper leaves of the fruit, 230g of curcuma, 350g of piercing stone, 140g of stomach friend, 300g of lily, 260g of brassica seed, 320g of licorice, 120g of bougainvillea, 250g of mustard seed, 140g of musk, 230g of Eucommia, 140g of tangerine, 330g of black plum, 200g of melon, 310g of dense flower tree, 160g of loofah, 320g of rubbing white leaf, 120g of Sanqi, 180g of dandelion, 220g of Polygonum sagittata, 130g of horizontal sutra mat, and millstone 310g grass, 260g sarsaparilla, 320g safflower and 140g seaweed;

[0093] The first step is to mix the upper leaves of the fruit, zedoary, piercing stone, stomach friend, lily and brassica, add ethanol with 60% alcohol concentration 4 times the amount of the mixture, and reflux extraction for 3 times, each time for 2.5 hours, and filter , the filtrates were combined, ethan...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating lacunar infarction and a preparation method thereof. The pharmaceutical composition is prepared from herb of heterophyllous eupatorium, herb of bulbophyllum odoratissimum (Swartz) Lindl., rhizoma curcumae, radix cudramiae, roots of sarcococca ruscifolia stapf, lilium brownii, seeds of brassica campestris L., licorice roots, roots, leaves and fruit of zanthoxylum avicennae (Lam.)DC., India mustard seeds, musk, cortex eucommiae, retinervus citri reticulatae, fructus mume, roots of fissistigma oldhami (Hemsl.) Merr., leaves or root bark of apanea neriifolia (Sieb.Et Zucc.)Mez., retinervus luffae fructus, roots, leaves and flowers of viburnum cylindricum Buch.-Ham. ex D. Don, radix notoginseng, herba taraxaci, herb of polygonum sieboldii Meisn., membranaceous beautyleaf roots, herb or roots of abutilon indicum (L.)G. Don, rhizomes and tender leaves of smilax glauco-china Warb., flos carthami, herb of lygodium japonicum(Thunb.)Sw, stems and roots of dalbergia hancei Benth., radix gentianae macrophyllae, ovate leaf holly bark and roots and herb of cyananthus argernteus Marg.. The pharmaceutical composition has the effects of promoting blood circulation to remove blood stasis, inducing resuscitation with herbal aromatics, dredging the channels, relieving hydrocephalus and improving microcirculation and has the advantages of being capable of rapidly achieving the effects, high in effective rate, exact in treatment effect, short in treatment course, capable of enhancing the effects, reducing toxicity and achieving multi-target treatment, low in cost and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating lacunar infarction and a preparation method thereof. Background technique [0002] Lacunar infarction is a relatively common type of cerebral infarction, accounting for about 20% of cerebral infarction. Completely different from atherosclerotic cerebral thrombosis, lacunar infarction mainly occurs in the deep penetrating branches of the anterior, middle, and posterior cerebral arteries and vertebral-basilar arteries and their branches, mainly caused by hypertension and its accompanying Caused by arteriolar hyaline degeneration or arterial embolism, the symptoms are relatively simple. It mostly occurs in the middle-aged and elderly people aged 40-60 and above, more men than women, the risk of lacunar infarction increases 8 times in hypertensive patients, and increases 5.6 times in smokers. Diabetic patients increase...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P9/10A61P7/02A61K35/55
CPCA61K36/28A61K9/0019A61K9/0095A61K9/1652A61K9/19A61K35/55A61K36/11A61K36/185A61K36/258A61K36/286A61K36/288A61K36/31A61K36/34A61K36/35A61K36/42A61K36/46A61K36/48A61K36/484A61K36/51A61K36/60A61K36/704A61K36/736A61K36/752A61K36/758A61K36/896A61K36/8967A61K36/898A61K36/90A61K36/9066A61K47/10A61K47/26A61K2236/15A61K2236/333A61K2236/51A61K2300/00
Inventor 刘广义
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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