Pharmaceutical composition for treating lacunar infarction and preparation method thereof
A composition and technology for cerebral infarction, applied in the directions of drug combination, medical formula, drug delivery, etc., can solve the problems of slurred speech, inaccurate pronunciation of words and intonation, unfavorable treatment, etc., to improve microcirculation and shorten the course of treatment. , the effect of relieving cerebral edema
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preparation example Construction
[0072] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:
[0073] The first step is to mix the raw medicinal materials according to the stated ratio, add ethanol whose alcohol concentration is 85% to 95% relative to the mixture 4 to 8 times, heat to boiling and reflux for 3 to 5 hours, filter, and use the percolation method Slowly percolate at a rate of 1-2ml per minute, collect the percolation liquid, then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C, spray dry, spray The air inlet temperature of the dryer is 160-175°C, and the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;
[0074] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obtain granules.
[0075] When the dos...
Embodiment 1
[0087] Embodiment 1 Granules
[0088] The preparation process of the granule of the present invention is as follows: get 160g of red cohosh, 320g of the upper leaves of the fruit, 200g of curcuma, 310g of piercing stone, 160g of stomach friend, 300g of lily, 240g of brassica seed, 300g of licorice, 150g of bougainvillea, 320g of mustard seed, 180g of musk, 240g of Eucommia, 180g of tangerine, 200g of black plum, 250g of melon wood, 320g of dense flower tree, 200g of loofah, 280g of rubbing white leaves, 120g of Sanqi, 320g of dandelion, 220g of Polygonum sagittata, 150g of horizontal sutra mat, and grinding disc 320g grass, 220g sarsaparilla, 170g safflower and 140g seaweed;
[0089] The first step is to mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a speed of 1.5ml per minute. Slowly percolate...
Embodiment 2
[0091] Embodiment 2 oral liquid
[0092] The preparation process of the oral liquid of the present invention is as follows: get 150g of red cohosh, 330g of the upper leaves of the fruit, 230g of curcuma, 350g of piercing stone, 140g of stomach friend, 300g of lily, 260g of brassica seed, 320g of licorice, 120g of bougainvillea, 250g of mustard seed, 140g of musk, 230g of Eucommia, 140g of tangerine, 330g of black plum, 200g of melon, 310g of dense flower tree, 160g of loofah, 320g of rubbing white leaf, 120g of Sanqi, 180g of dandelion, 220g of Polygonum sagittata, 130g of horizontal sutra mat, and millstone 310g grass, 260g sarsaparilla, 320g safflower and 140g seaweed;
[0093] The first step is to mix the upper leaves of the fruit, zedoary, piercing stone, stomach friend, lily and brassica, add ethanol with 60% alcohol concentration 4 times the amount of the mixture, and reflux extraction for 3 times, each time for 2.5 hours, and filter , the filtrates were combined, ethan...
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