Natural product anti-inflammation medicine composition and use thereof
An anti-inflammatory drug and composition technology, applied in the field of medicine, can solve problems such as adverse reactions, and achieve the effects of clear pharmacological effects, reduced foot swelling, and reduced release
Inactive Publication Date: 2016-05-25
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology
Non-steroidal drugs are currently recommended first-line drugs for the treatment of inflammatory diseases, including aspirin, acetaminophen, diclofenac, indomethacin, ibuprofen, etc., but these drugs have corresponding side effects, such as adverse gastrointestinal tract reaction etc.
Method used
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Embodiment 1
[0024] Embodiment 1 physical mixing
[0025] Take 0.7g ligustrazine, 0.18g resveratrol, 1.75g curcumin, mix physically, and dissolve 0.5% sodium carboxymethylcellulose for animal experiments or clinical oral administration.
Embodiment 2
[0026] Embodiment 2 physical mixing
[0027] Take 3.0g ligustrazine, 0.83g resveratrol, 11.25g curcumin, mix physically, and dissolve 0.5% sodium carboxymethylcellulose for animal experiments or clinical oral administration.
Embodiment 3
[0028] Embodiment 3 physical mixing
[0029] Take 1.85g ligustrazine, 0.93g resveratrol, 9.25g curcumin, mix physically, and dissolve 0.5% sodium carboxymethylcellulose for animal experiments or clinical oral administration.
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The invention relates to a natural product anti-inflammation medicine composition and a use thereof. Every dosage unit includes 0.7-3.0g of ligustrazine, 0.1-1.1g of resveratrol and 1.7-11.7g of curcumin, and the dosage unit is the total amount of the above medicine precision used every day. The medicine composition adopting ligustrazine, resveratrol and curcumin as active components is prepared through directly physically mixing 0.7-3.0g of ligustrazine, 0.1-1.1g of resveratrol and 1.7-11.7g of curcumin, or a pharmaceutically acceptable carrier is added to make the total weight of ligustrazine, resveratrol and curcumin account for 0.5-40% of the total weight of the medicine composition in order to prepare any clinically acceptable oral dosage form. The invention also provides a use of the medicine composition adopting the ligustrazine, resveratrol and curcumin as active components in the preparation of anti-inflammation medicines. The medicine composition adopting the ligustrazine, resveratrol and curcumin as active components has the characteristics of simple preparation method, convenient quality control, high efficiency and low toxicity, and can be used to treat pneumonia, hepatitis, nephritis, arthritis, pyohemia, ulcerative colitis, asthma, atherosclerosis and other clinic common inflammation diseases.
Description
technical field [0001] The present invention belongs to the technical field of medicine, and in particular relates to a natural product anti-inflammatory pharmaceutical composition and its use, in particular to the preparation of three natural products of ligustrazine, resveratrol and curcumin into a pharmaceutical composition, and the preparation of the pharmaceutical composition in Application in the preparation of anti-inflammatory drugs. Background technique [0002] Inflammation can usually be divided into two categories according to the course of the disease: acute inflammation (acute inflammation) and chronic inflammation (chronic inflammation). Acute inflammation has a sudden onset and a short duration of only a few days to a month. It is characterized by exudative lesions, and the infiltration of inflammatory cells is mainly granulocytes. Chronic inflammation lasts for a long time, constant months to several years, mainly hyperplastic lesions, and its inflammatory ...
Claims
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IPC IPC(8): A61K31/4965A61P29/00A61P11/00A61P1/16A61P13/12A61P19/02A61P1/04A61P11/06A61P9/10A61K31/05A61K31/12
Inventor 刘天军陈龙刘娟洪阁
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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