Method for preparing optically active carbonyl compound

Abstract

The invention discloses a method for preparing an optically active carbonyl compound, which comprises the following step: under catalysis of a chiral amine salt and a transition metal catalyst, carrying out asymmetric catalytic hydrogenation reaction on alpha, beta-unsaturated aldehyde or alpha, beta-unsaturated ketone compound by taking hydrogen gas and a catalysis amount of dihydropyridine compound as a hydrogen source, so as to obtain the optically active carbonyl compound. The method has mild reaction conditions and simple operation, and the use amount of the dihydropyridine compound is the catalysis amount, so that a target product is easily separated and purified from a reaction system; and at the same time, the metal catalyst can be recycled, thereby meeting the economy requirement.

Description

technical field [0001] The invention belongs to the technical field of asymmetric catalytic organic synthesis, and specifically relates to a method for preparing an optically active carbonyl compound by using an α, β-unsaturated aldehyde or α, β-unsaturated ketone compound as a raw material through an asymmetric catalytic hydrogenation reaction. Background technique [0002] Optically active carbonyl compounds are important intermediates in the synthesis of medicines, flavors and fragrances, and pesticides. The selective asymmetric hydrogenation of carbon-carbon double bonds of α,β-unsaturated carbonyl compounds is an important way to obtain optically active carbonyl compounds. Chemists have developed different methods for selective asymmetric hydrogenation of carbon-carbon double bonds of α,β-unsaturated carbonyl compounds. These methods and their technical problems are as follows: [0003] (1) The homogeneous catalytic reaction using hydrogen as the hydrogen source, becau...

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Problems solved by technology

At present, the biomimetic asymmetric catalyst technology is mainly used in the asymmetric hydrogenation of carbon-nitrogen double bonds of unsaturated imines, but there is no literature report on the asymmetric hydrogenation of carbon-carbon double bonds of unsaturated carbonyl compounds.

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