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Process for producing astragalus polysaccharide by using ultrasonic technology

An astragalus polysaccharide and ultrasonic technology are applied in the directions of antibacterial drugs, antiviral agents, and drug combinations, which can solve the problems of the purity and low extraction rate of astragalus polysaccharides, and achieve ecological feeding, improve immunity, and improve extraction yield. Effect

Inactive Publication Date: 2016-04-20
陈燕妮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the existing medicinal licorice extracts of astragalus polysaccharides such as low purity and low extraction rate, and to provide a process for producing astragalus polysaccharides using water extraction technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In this embodiment, dry Radix Astragali is used as a raw material, and the preparation method steps include:

[0019] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried, and crushed, then added 12 times of water (washed with water for 3 times, crushed into astragalus root to 50 mesh), ultrasonic power 280W, temperature 60 The extraction was carried out at ℃ for 0.5h, and the combined extracts were left to cool to obtain a crude extract;

[0020] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, the addition amount is 5g / L, and after standing for 30min, rotate and evaporate to concentrate Crude extract, to the extract whose water specific gravity d is 1.50, obtains the crude extract;

[0021] 3) Dissolving and removing impurities: add ethanol to the crude extract obtained in step 2), the amount of ethanol added is 5 ...

Embodiment 2

[0024] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried, and crushed, then added 15 times of water (cleaning is washed twice with water, crushed to 100 meshes of Radix Astragali), ultrasonic power is 200W, temperature is 70 The extraction was carried out at ℃ for 1.5 hours, and the combined extracts were left to cool to obtain a crude extract;

[0025] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, and the addition amount is 10g / L. After standing for 20 minutes, rotate and evaporate to concentrate Crude extract, to the extract whose water specific gravity d is 1.0, obtains the crude extract;

[0026] 3) Dissolving and removing impurities: add ethanol to the crude extract obtained in step 2), the amount of ethanol added is 2 times the volume of the extract, stir the extract to dissolve, let it stand for precipitation, a...

Embodiment 3

[0029] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried and crushed, then added 9 times of water (cleaned with water for 3 times, crushed into Astragalus root to 75 mesh), ultrasonic power 250W, temperature 65 The extraction was carried out at ℃ for 1.0 h, and the combined extracts were left to cool to obtain a crude extract;

[0030] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, the addition amount is 7.5g / L, let stand for 25min and then rotate to evaporate Concentrating the crude extract to obtain an extract whose water specific gravity d is 1.20 to obtain a crude extract;

[0031] 3) Dissolving and removing impurities: add ethanol to the crude extract obtained in step 2), the amount of ethanol added is 3 times the volume of the extract, stir the extract to dissolve, let it stand for precipitation, and centrifuge to...

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Abstract

The invention relates to the technical field of radix astragali medicine extraction, in particular to a process for producing astragalus polysaccharide by using an ultrasonic technology. The process comprises the steps of washing, drying and smashing dry radix astragali, adding water, performing extraction for 0.5 to 1.5h for three times under the condition that the ultrasonic power is 200 to 280W, and the temperature is 60 to 70 DEG C, combining extracting solutions, standing for cooling, adding a natural plant extract clarifying agent KBT-ZTC, standing and then performing rotary evaporation and concentration on a crude extract to obtain an extract crude product; adding ethyl alcohol into the extract crude product, stirring the extract to dissolve, performing static settlement, centrifuging to remove liquid supernatant to obtain precipitate, adding ethyl alcohol again, stirring and centrifuging to obtain pure astragalus polysaccharide. According to the process, electromagnetic energy is converted into thermal energy by using ultrasonic waves to enable a cell membrane to break, intracellular matters such as the astragalus polysaccharide are released and dissolved out, and an introduced clarification and purification process can effectively remove macromolecule impurities such as protein, nucleic acid and starch in the astragalus polysaccharide.

Description

technical field [0001] The invention belongs to the technical field of astragalus medicine extraction, and in particular relates to a process for producing astragalus polysaccharides by ultrasonic technology. Background technique [0002] Astragalus is a leguminous plant, sweet in taste, slightly warm in nature, and belongs to the lung and spleen meridian. Astragalus polysaccharide (APS) is a polysaccharide extracted from the traditional Chinese medicine Astragalus, mainly composed of fructose, rhamnose, arabinose, hexuronic acid, glucose, galacturonic acid and glucuronic acid. Because it has the functions of enhancing immune system function, anti-tumor, protecting liver, lowering blood sugar, anti-virus, anti-oxidation and delaying aging. In veterinary clinics, astragalus polysaccharides have obvious effects on immune regulation, anti-virus, and anti-bacteria. They are widely used as immune enhancers and immune adjuvants, and can be used to prevent piglet diarrhea, porcine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P37/02A61P31/04A61P31/12
CPCC08B37/0003C08B37/00
Inventor 陈燕妮
Owner 陈燕妮
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