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Medical multi-layer composite anti-adhesion membrane and preparation method thereof

An anti-adhesion film, multi-layer composite technology, applied in the field of biomedicine, can solve the problems of fast absorption cycle of sodium carboxymethyl cellulose film, poor adhesion between the anti-adhesion film and tissue, poor mechanical properties and operability, etc. Reduced fibroblast proliferation, good structural stability, good histocompatibility

Active Publication Date: 2016-04-20
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these anti-adhesion films still have some disadvantages
The polylactic acid anti-adhesion film has poor adhesion to the tissue. It needs to be sutured to fix the anti-adhesion film and the tissue during the operation, which is not conducive to the operation of deep lesions. The oxidized cellulose film must be completely hemostasis before use. Bleeding can not be used; sodium carboxymethylcellulose film has a faster absorption cycle, and its mechanical properties and operability are poor in a wet environment (DisColonRectum, 2013, 56, 1174-1184.)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Step 1: Dissolve 15 parts of polyvinyl alcohol 1799 and 1 part of sodium carboxymethylcellulose (viscosity in 20g / L aqueous solution is 800-1200cp, degree of substitution is 0.7) in 84 parts of deionized water (by mass, the same below ), to obtain mixed solution A. After the mixed solution A was cast, it was frozen at -20°C for 12 hours, and then thawed at room temperature for 2 hours. The above freezing-thawing process was carried out three times to obtain a gel film with a thickness of 500 μm.

[0019] Step 2: Dissolve 8 parts of polyvinyl alcohol 1788, 4 parts of sodium carboxymethylcellulose (viscosity in 20g / L aqueous solution is 800-1200cp, degree of substitution is 0.7), 4 parts of zinc sulfate heptahydrate in 84 parts of deionized water , to obtain mixed solution B. The mixed solution B was cast on one side of the gel film obtained in step 1, and the solvent was evaporated at room temperature to obtain a double-layer composite film containing a water-soluble fi...

Embodiment 2

[0027] Step 1: Dissolve 15 parts of polyvinyl alcohol 1799, 1 part of sodium carboxymethylcellulose (viscosity in 20g / L aqueous solution is 800-1200cp, degree of substitution 0.7), 1 part of p-hydroxybenzoic acid in 83 parts of deionized water, Mixed solution A was obtained. After the mixed solution A was cast, it was frozen at -20°C for 12 hours, and then thawed at room temperature for 2 hours. The above freezing-thawing process was carried out three times to obtain a gel film with a thickness of 500 μm.

[0028] Step 2: Dissolve 8 parts of polyvinyl alcohol 1788 and 4 parts of sodium carboxymethylcellulose (viscosity in 20 g / L aqueous solution is 800-1200 cp, degree of substitution 0.7) in 88 parts of deionized water to obtain mixed solution B. The mixed solution B was cast on one side of the gel film obtained in step 1, and the solvent was evaporated at room temperature to obtain a double-layer composite film containing a water-soluble film with a thickness of 100 μm on the...

Embodiment 3

[0036] Step 1: Dissolve 15 parts of polyvinyl alcohol 1799 and 1 part of sodium carboxymethylcellulose (viscosity in 20 g / L aqueous solution is 800-1200 cp, degree of substitution 0.7) in 84 parts of deionized water to obtain mixed solution A. After the mixed solution A was cast, it was frozen at -20°C for 12 hours, and then thawed at room temperature for 2 hours. The above freezing-thawing process was carried out three times to obtain a gel film with a thickness of 500 μm.

[0037] Step 2: 4 parts of polyvinyl alcohol 1788, 4 parts of sodium carboxymethyl cellulose (viscosity in 20g / L aqueous solution is 800-1200cp, degree of substitution 0.7), 4 parts of calcium chloride are dissolved in 88 parts of deionized water to obtain Mix Solution B. Cast the mixed solution B on one surface of the gel film obtained in step 1, and evaporate the solvent at room temperature; then cast the mixed solution B on the other surface of the gel film obtained in step 1, and evaporate the solvent ...

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Abstract

The invention belongs to the technical field of biomedicine and particularly relates to a medical multi-layer composite anti-adhesion membrane and a preparation method thereof. The multi-layer composite anti-adhesion membrane comprises a gel membrane, a single surface or double surfaces of the gel membrane is a water-soluble membrane or are water-soluble membranes. During preparation, the gel membrane can be prepared firstly, and then the water-soluble membrane or the water-soluble membranes is / are arranged on the single surface or the double surfaces of the gel membrane in a curtain coating manner; besides, the gel membrane and the water-soluble membrane or the water-soluble membranes can be prepared respectively firstly and then composited in a little-water environment. With the adoption of the multi-layer composite anti-adhesion membrane, on one hand, the anti-adhesion membrane can be bonded to tissue and organs through slow dissolution of the water-soluble membrane or the water-soluble membranes, and suture fixing operation of the anti-adhesion membrane during an operation is avoided; on the other hand, due to stable existence of the gel membrane, the anti-adhesion membrane can still have effects of a mechanical support and a physical barrier after being implanted in a body for a longer time, and postoperative adhesion is inhibited. The multi-layer composite anti-adhesion membrane has the wide application value in postoperative adhesion prevention for parts such as hearts, abdominal cavities, pelvic cavities and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a medical multilayer composite anti-adhesion film and a preparation method thereof. Background technique [0002] Postoperative adhesion is the most common and difficult problem in surgical treatment of abdominal cavity, pelvic cavity, heart and other parts. It not only causes serious complications, but also is the main reason for the obvious increase in the probability of complications after secondary surgery. Usually, before the surgical wound is sutured, the surgeon will place a layer of anti-adhesion film with physical isolation between the operated tissues or organs, so as to prevent the occurrence of tissue and organ adhesion. [0003] The anti-adhesion materials that have been used in surgical treatment mainly include two categories: non-degradable absorbent materials and degradable absorbent materials. Non-degradable absorbent materials, such as polytetra...

Claims

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Application Information

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IPC IPC(8): A61B90/00A61L31/04A61L31/14
CPCA61L31/041A61L31/042A61L31/048A61L31/145A61L31/148C08L29/04C08L1/286C08L5/08
Inventor 郭宝华戴泽辉胡畅吴清玉李雷徐军胡一宗
Owner TSINGHUA UNIV
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