Methacrylate fluorescent monomer with thiazolepyridine structure and preparation method thereof

Abstract

A methacrylate fluorescent monomer with thiazolepyridine structure and a preparation method thereof are disclosed. The methacrylate fluorescent monomer with the thiazolepyridine structure is prepared using thiazolepyridine-3-carboxyl and hydroxyethyl methacrylate as starting materials or thiazolepyridine-3,7-dicarboxyl and hydroxyethyl methacrylate as starting materials. A synthetic method of the invention has few side products, the prepared methacrylate fluorescent monomer is high in product purity and high in quantum yield, the synthetic method is simple to operate, has mild reaction conditions and allows large-scale preparation and easy industrialization, and fluorescent polymers are easy to prepare through polymerization reaction.

Description

technical field [0001] The invention belongs to the technical field of fluorescent compound synthesis, and in particular relates to a methacrylate fluorescent monomer containing a thiazopyridone structure and a preparation method thereof. Background technique [0002] After the fluorescent compound is excited by ultraviolet light, electricity or chemical energy, the electrons transition from the ground state to the excited state, and then release photons through radiative decay to return to the ground state and generate fluorescence. The application of fluorescent compounds has penetrated into biomedical fields such as biosensing, bioimaging, and photodynamic therapy, as well as the fields of three-dimensional information storage and microprocessing. [0003] On the other hand, with the emergence of new reactions and new polymerization methods, such as click chemistry (Click) reaction, atom transfer radical polymerization (ATRP), nitrogen-oxygen stabilized radical polymeriza...

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Problems solved by technology

[0004] The synthesis of fluorescent polymers usually requires polymerizable fluorescent monomers, and there are some problems in the research on the latter: 1) Most fluorescent compounds are conjugated organic molecules, which are difficult to dissolve in water and complex to synthesize, making it difficult to popularize and apply

2) Even if fluorescent molecules are bonded to hydrophilic polymer chains, their quantum yields are easily affected by solvents and are generally lower in water

3) Olefin monomers constructed by conjugated organic molecules have a large steric hindrance, which is easy to affect the free radical polymerization process, and it is difficult to synthesize fluorescent polymers with high polymerization degrees

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