Multifunctional gadolinium-contained hollow mesoporous Prussian-blue nanometer treatment agent and preparation method and application thereof
A Prussian blue and hollow mesoporous technology, applied in the field of nanomaterials and biomedical materials, can solve the problems that photoacoustic imaging and photothermal therapy cannot be realized, contrast agents cannot be adjusted by near-infrared absorption, and cannot be used as sensitive chemical probes. Achieve excellent photothermal conversion performance, good clinical application prospects, and improve the efficiency of diagnosis and treatment
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[0043] In one embodiment, the preparation method of HGPB nanoparticle of the present invention comprises the steps:
[0044] a) fully mixing the gadolinium source, the organic polymer protective agent with good biocompatibility and reducibility and the acid and the iron source, the organic polymer protectant with good biocompatibility and reducibility and the acid at room temperature;
[0045] b) adding the mixed gadolinium source solution dropwise to the iron source solution, and continuing magnetic stirring;
[0046] c) transfer the solution to a certain temperature environment for processing;
[0047] d) 13000rpm / min, centrifuged for 10 minutes to collect the Prussian blue nanoparticles containing gadolinium;
[0048] e) A certain quality of the above-mentioned nanoparticles, a certain concentration of acid, and an organic polymer protective agent with good biocompatibility and reducibility are fully mixed, placed in an oven at a certain temperature, and etched for a certa...
Embodiment 1
[0068] Preparation of monodisperse, uniform size mesoporous Prussian blue nanoparticles:
[0069]a) 45mg gadolinium nitrate, 1g polyvinylpyrrolidone and hydrochloric acid solution with a concentration of 0.01mol / L and 33mg potassium ferricyanide, 1g polyvinylpyrrolidone and 0.01mol / L hydrochloric acid solution are fully mixed at room temperature;
[0070] b) Add the mixed gadolinium source solution dropwise into the iron source solution at a rate of 40ml / h, and continue magnetic stirring for 3h;
[0071] c) Transfer the solution to an oven at 80°C for aging for 24 hours;
[0072] d) 13000rpm / min, centrifuged for 10 minutes to collect the Prussian blue nanoparticles containing gadolinium;
[0073] e) The above-mentioned nanoparticles of a certain quality are fully mixed with a certain concentration of acid, placed in an oven at a certain temperature, etched for a certain period of time, 13000rpm / min, and centrifuged for 10 minutes to obtain HGPB nanoparticles, as follows:
[...
Embodiment 2
[0078] Preparation of gadolinium-containing hollow mesoporous Prussian blue nanoparticles with an iron-gadolinium ratio of 200:1:
[0079] a) 45mg gadolinium nitrate, 1g polyvinylpyrrolidone and hydrochloric acid solution with a concentration of 0.01mol / L and 33mg potassium ferricyanide, 1g polyvinylpyrrolidone and 2mol / L hydrochloric acid solution were fully mixed at room temperature;
[0080] b) Add the mixed gadolinium source solution dropwise into the iron source solution at a rate of 40ml / h, and continue magnetic stirring for 3h;
[0081] c) Transfer the solution to an oven at 80°C for aging for 24 hours;
[0082] d) 13000rpm / min, centrifuged for 10 minutes to collect the Prussian blue nanoparticles containing gadolinium;
[0083] e) The above-mentioned nanoparticles of a certain quality are fully mixed with a certain concentration of acid, placed in an oven at a certain temperature, etched for a certain period of time, 13000rpm / min, and centrifuged for 10 minutes to obt...
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