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Vegetable oil composition with effect of preventing and treating Alzheimer's disease as well as preparation method and application thereof

An Alzheimer's disease, vegetable oil technology, applied in drug combination, medical preparations containing active ingredients, applications, etc., can solve the problems of human liver and muscle tissue damage, limit clinical application and other problems, improve sleep, shorten search distance, The effect of improving spatial learning and memory ability

Active Publication Date: 2016-01-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The medicines used in the prior art to prevent and treat Alzheimer's disease mainly include medicines for improving choline neurotransmission (such as tacrine), medicines for improving cerebral blood circulation and brain cell metabolism, etc. Most of them are artificially synthesized, and long-term use can damage human liver. and muscle tissue damage, limiting the clinical application of such products

Method used

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  • Vegetable oil composition with effect of preventing and treating Alzheimer's disease as well as preparation method and application thereof
  • Vegetable oil composition with effect of preventing and treating Alzheimer's disease as well as preparation method and application thereof
  • Vegetable oil composition with effect of preventing and treating Alzheimer's disease as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1 A kind of preparation method of the vegetable oil composition with preventing and treating Alzheimer's disease, comprises the steps:

[0032] (1) Get gardenia, pulverize and cross 40 mesh sieves, charge, seal, CO 2Supercritical fluid extraction, extraction pressure 38MPa, extraction temperature 55°C, extraction time 60min, separated to obtain gardenia oil.

[0033] (2) Get Semen jujuba, pulverize through a 40-mesh sieve, charge, seal, CO 2 Supercritical fluid extraction, extraction pressure 41MPa, extraction temperature 49°C, extraction time 60min, the jujube seed oil was obtained after separation.

[0034] (3) Get ginkgo fruit, pulverize and cross 40 mesh sieves, charge, seal, CO 2 Supercritical fluid extraction, extraction pressure 42MPa, extraction temperature 50°C, extraction time 60min, ginkgo oil was obtained after separation.

[0035] (4) Get Schisandra chinensis and pulverize through a 40-mesh sieve, charge, seal, CO 2 Supercritical fluid extrac...

Embodiment 2

[0039] Embodiment 2 A kind of vegetable oil composition with prevention and treatment of Alzheimer's disease

[0040] (1) get respectively 6 parts of gardenia oils of embodiment 1 step (1) gained, 25 parts of jujube kernel oils of step (2) gained, 4 parts of ginkgo oil of step (3) gained, the schisandra fruit of step (4) gained 4 parts of oil, 50 parts of linseed oil obtained in step (5), and 11 parts of safflower oil obtained in step (6) were placed in a stainless steel tank and stirred evenly, and the mixed oil was ground 2 to 3 times through a colloid mill to make Mix to form a uniform liquid and cool down to room temperature to obtain a natural vegetable oil composition.

[0041] (2) Take the natural vegetable oil composition prepared in step (1), use gelatin, glycerin, etc. as capsule shell materials, and use a soft capsule machine to compress into soft capsules, each 0.5g.

Embodiment 3

[0042] Embodiment 3 A kind of vegetable oil composition that has the effect of preventing and treating Alzheimer's disease

[0043] (1) Get respectively 4 parts of gardenia oil obtained in embodiment 1 step (1), 20 parts of Jujube Seed Oil obtained in step (2), 7 parts of ginkgo oil obtained in step (3), Schisandra chinensis obtained in step (4) 7 parts of oil, 50 parts of linseed oil obtained in step (5), 12 parts of safflower seed oil obtained in step (6) are placed in a stainless steel tank and stirred evenly, and the mixed oil is ground 2 to 3 times through a colloid mill to make Mix to form a uniform liquid and cool down to room temperature to obtain a natural vegetable oil composition. It is clad with cyclodextrin and then evenly mixed with lactose, granulated, and then packed into capsules to make hard capsules.

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Abstract

The invention discloses a vegetable oil composition with an effect of preventing and treating Alzheimer's disease as well as a preparation method thereof. The vegetable oil composition is prepared from the following raw materials in parts by weight: 1-20 parts of gardenia oil, 5-50 parts of jujube seed oil, 1-20 parts of ginkgo oil, 1-20 parts of Chinese magnoliavine fruit oil, 10-80 parts of flaxseed oil and 5-50 parts of safflower oil. The vegetable oil composition provided by the invention is prepared by screening and optimizing by virtue of a lot of experiences, and is also prepared by adopting vegetable oil which is prepared from natural traditional medicinal and edible plants with multiple medicinal healthcare effects by virtue of a modern preparation process and has a healthcare effect; and experimental results show that the vegetable oil composition provided by the invention can improve spatial learning and memory abilities of a senile dementia model mouse and shorten the escape latency and the scouting distance of the senile dementia model mouse, can reduce the oxidation damage degree of brain tissues of the mouse and inhibit the activity of acetylcholine esterase in the brain tissues at the same time, has very good prevention and treatment effects on the Alzheimer's disease, and can be used for preventing and treating the symptoms of amnesia, insomnia, dysphoria and the like of the Alzheimer's disease.

Description

technical field [0001] The invention relates to a natural vegetable oil composition, in particular to a vegetable oil composition capable of preventing and treating Alzheimer's disease, a preparation method and application thereof. Background technique [0002] Senile dementia is a degenerative disease of the central nervous system and the most common type of senile dementia. It is mainly manifested in neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes and language barriers, and seriously affects social interaction. , Occupation and life function are persistent diseases that affect the health of the elderly. According to statistics, about 10% of the elderly population over the age of 60 in the world suffers from this disease. At present, more than 18 million elderly people in the world suffer from Alzheimer's disease. In my country, there will be an increase of 6 million elderly people every year, and the number and i...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K36/79A61P25/28C11B9/00A23L1/29
Inventor 郭盛段金廒钱大玮
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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