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Application of pawpaw total triterpene and components thereof in pharmacy

A technology of total triterpenes and papaya, applied in the field of medicine, can solve the problems of easy recurrence, large side effects, affecting the healing of gastric ulcers, etc.

Inactive Publication Date: 2016-01-06
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, researchers have found that this kind of drugs may affect the healing of gastric ulcer just like traditional NSAIDs; 2 Receptor antagonists and proton pump inhibitors are used to protect the gastric mucosa, but the curative effect is often not durable, and recurrence is easy after drug withdrawal, and the cost is large, and the side effects are also large, so long-term use is limited

Method used

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  • Application of pawpaw total triterpene and components thereof in pharmacy
  • Application of pawpaw total triterpene and components thereof in pharmacy
  • Application of pawpaw total triterpene and components thereof in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The total papaya triterpenes are extracted from wrinkled papaya, which is specifically prepared by the following method:

[0017] 1) Pretreatment of wrinkled papaya

[0018] The near-ripe fruit of wrinkled papaya is washed, sliced ​​and dried in the sun, and 0.005 kg is taken for preservation, and the rest is dried in a constant temperature blower box at 48°C to constant weight, with a net weight of 5.0 kg.

[0019] 2) Depigmentation of wrinkled papaya

[0020] The sample was pulverized with a pulverizer, crossed a 20-mesh sieve, and used sherwood oil as a solvent at a liquid-solid ratio of 6:1, decolorized 3 times at 60° C. for 2 hours each time, and obtained 4.26 kg of papaya coarse powder after decolorization (see figure 1 ).

[0021] 3) Reflux extraction of papaya coarse powder after decolorization

[0022] The decolorized papaya coarse powder obtained in the above 2) was extracted with ethyl acetate as a solvent at a liquid-solid ratio of 5:1, and refluxed at 50...

Embodiment 2

[0030] The application of the total triterpenoids of papaya and one of its important components, oleanolic acid, in the treatment of gastric mucosal damage caused by non-steroidal anti-inflammatory drugs will be specifically described below in combination with specific experimental examples.

[0031] experiment method

[0032] 1) Experimental animals

[0033] Provided by the Experimental Animal Center of China Three Gorges University, 90 male Kunming mice of SPF grade, weighing 18-22g, the experimental animal quality certificate number: SCXK (E) 2011-0012; the animals were kept in a dry, ventilated and quiet environment in an ordinary animal room , 5 / cage.

[0034] 2) Instruments and reagents

[0035] WFZUV-2100 UV-Vis spectrophotometer: Shanghai Unico Instrument Co., Ltd.; full-wavelength microplate reader: Tecan, Switzerland; TP1020 dehydrator: Leica, Germany; ULTRACUTR ultrathin microtome: Leica, Austria; CS- V1 slicer: Xiaogan Hongye Medical Instrument Co., Ltd.; DMR mu...

experiment example 3

[0075] The application of the total triterpenes of papaya and one of its important components, oleanolic acid, in the treatment of small intestinal mucosal injury caused by non-steroidal anti-inflammatory drugs will be specifically described below in combination with specific experimental examples.

[0076] experiment method

[0077] 1) Experimental animals

[0078] Provided by the Experimental Animal Center of China Three Gorges University, 90 SPF-grade male Wistar rats, weighing 180-220g, experimental animal quality certificate number: SCXK (E) 2011-0012; the animals were kept in a dry, ventilated, and quiet environment in an ordinary-grade animal room , 5 / cage.

[0079] 2) Instruments and reagents

[0080] WFZUV-2100 UV-Vis spectrophotometer: Shanghai Unico Instrument Co., Ltd.; full-wavelength microplate reader: Tecan, Switzerland; TP1020 dehydrator: Leica, Germany; ULTRACUTR ultrathin microtome: Leica, Austria; CS- V1 type spreader and roaster: Xiaogan Hongye Medical I...

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Abstract

The invention provides application of pawpaw total triterpene and components thereof (including oleanolic acid, ursolic acid, acetyl ursolic acid, betulinic acid, maslinic acid, acetyl pomolic acid and tormentic acid), including the following pawpaw total triterpene and components thereof or pharmaceutically acceptable salt, in medicines for treating digestive duct injury as active ingredients, wherein the digestive duct injury is caused by non-steroidal anti-inflammatory drugs. Results show that the pawpaw total triterpene and oleanolic acid, which is an important triterpene component, take a relatively good therapeutic effect on indometacin-caused mice gastric mucosal injury and diclofenac sodium-caused mice intestinal mucosa injury; therefore, an effective and safe medicine is provided for preventing and treating digestive duct injury due to use of NASIDs, and especially for preventing and treating peptic ulcer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of total triterpenes in papaya and components thereof in treating digestive tract damage. Background technique [0002] Nonsteroidal anti-inflammatory drugs (nonsteroidalanti-inflammatory drugs, NSAIDs) are a class of anti-inflammatory drugs widely used clinically, and are the first-line treatment drugs for many bone and joint diseases such as rheumatoid arthritis and osteoarthritis; in recent years, non-steroidal anti-inflammatory drugs have been found Anti-inflammatory drugs can reduce the incidence of colon cancer, and more and more people take low-dose aspirin for a long time to prevent cardiovascular and cerebrovascular diseases and the increase of over-the-counter drugs, making NSAIDs become the most used drugs in the world One, its consumption in China is second only to anti-infective drugs. With its wide clinical application, more and more pe...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61K31/56A61P1/00
Inventor 贺海波张永峰石孟琼汪鋆植覃慧林刘呈雄周琴程凡邹坤张继红
Owner CHINA THREE GORGES UNIV
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