Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A near-infrared photothermal response anticancer drug nanocapsule and its preparation method

An anti-cancer drug, near-infrared light technology, applied in the directions of drug combination, microcapsule, capsule delivery, etc., can solve the problems of no longer having near-infrared photothermal effect, failure of photothermal nanomedicine capsules, and stability of gold nanorods. , to achieve long-term stable photothermal conversion efficiency, ultra-high photothermal conversion efficiency, and high drug loading effects

Active Publication Date: 2018-03-30
BEIJING UNIV OF CHEM TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a system still faces the problem of the stability of gold nanorods. After a period of illumination, gold nanorods are prone to structural changes, from nanorods to nanospheres, and its near-infrared photothermal effect is closely related to its shape. After being formed into nanospheres, it no longer has the near-infrared photothermal effect, resulting in the failure of photothermal nano drug capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A near-infrared photothermal response anticancer drug nanocapsule and its preparation method
  • A near-infrared photothermal response anticancer drug nanocapsule and its preparation method
  • A near-infrared photothermal response anticancer drug nanocapsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] a.0.5mg Cu 1.75 S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu 1.75 S@allylthiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0020] b. 1.0mL contains 0.5mg of Cu 1.75 The chloroform dispersion of S@allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 5 mg bisacrylamide (MBA, cross-linked). Joint agent) sodium dodecylsulfonate (SDS) solution (sodium dodecylsulfonate concentration 1.0mg / mL), under vigorous stirring and ultrasound, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then Heat to 70°C, quickly add 1.0mL (10mg / mL) potassium persulfat...

Embodiment 2

[0024] a.0.5mg Cu 1.75 S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu 1.75 S@allylthiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0025] b. 1.0mL contains 0.5mg of Cu 1.75 The chloroform dispersion of S@allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 10 mg bisacrylamide (MBA, monomer). Sodium dodecylsulfonate (SDS) solution (1.0mg / mL), under vigorous stirring and ultrasonication, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then heated to 70°C, and 1.0 mL (10mg / mL) potassium persulfate (KPS, initiator) solution, maintained at 70°C for 5 h...

Embodiment 3

[0028] a.0.5mg Cu 1.75S nanosheets were dispersed in 5.0mL chloroform, 8uL allyl mercaptan (Alm) was added and stirred slowly at 30°C for 30 minutes; after that, acetone was added to the solution, centrifuged (10000r / min, 10min), and then chloroform and acetone The excess Alm was washed away, and this purification process was repeated 3 times to obtain Cu 1.75 S@allylthiol nanoparticles were then dispersed into 1.0 mL of chloroform;

[0029] b. 1.0mL contains 0.5mg of Cu 1.75 The chloroform dispersion of S@allylthiol nanoparticles was mixed with 15 mL containing 300 mg N-isopropylacrylamide (NIPAM, monomer), 15 μg methacrylic acid (MAA, monomer) and 15 mg bisacrylamide (MBA, monomer). Sodium dodecylsulfonate (SDS) solution (1.0mg / mL), under vigorous stirring and ultrasonication, a brown emulsion was obtained; chloroform was evaporated at 58°C for 20 minutes; then heated to 70°C, and 1.0 mL (10mg / mL) potassium persulfate (KPS, initiator) solution, maintained at 70°C for 5 ho...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses near-infrared photothermal response anticancer drug nanocapsules and a preparation method thereof. The present invention combines the near-infrared photothermal properties of Cu1.75S NPs and the pH- and temperature-sensitive properties of p(NIPAM‑MAA), and covers the surface of Cu2‑xS nanoparticles with near-infrared photothermal effect by in-situ polymerization For polymers that are sensitive to pH and temperature, the thickness of the outer polymer of the nanocapsule can be changed by adjusting the amount of the cross-linking agent bisacrylamide, and then loaded with anticancer drugs. Leakage is minimal under light conditions. The nanocapsule of the invention has long-term stable ultra-high photothermal conversion efficiency, high drug load (40%) and excellent biocompatibility. Further in vitro and in vivo photothermal chemotherapy results indicated that the nanocapsules could be used for long-range damage-free photothermal drug delivery, long-term sustained photothermal therapy, and photothermal-controlled chemotherapy.

Description

technical field [0001] The invention belongs to the technical field of nano-medicine preparations, and in particular relates to a near-infrared photothermal response anticancer drug nanocapsule and a preparation method thereof. technical background [0002] Cancer treatment is faced with serious toxic and side effects problems, reducing toxic and side effects and improving treatment effects are the ultimate goals of basic cancer research and clinical treatment in medicine. The controlled release of anticancer drugs is an important means to solve this problem. Temperature, magnetic field, and light are few in vitro stimulating conditions that can be used to stimulate drug release and are relatively easy to control. Among them, temperature, as the most commonly used external stimulus for drug release, has been studied most extensively and deeply. Many drug capsules can release drugs in response to temperature, however, most of the related studies are limited to in vitro expe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K31/704A61K47/32A61P35/00
Inventor 汪乐余黄盛
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com