Preparation method of multifunctional medicinal polylactic acid (PLA) derivative ABC triblock polymer
A technology of polylactic acid and star-shaped copolymer is applied in the preparation of star-shaped block copolymer porous drug carriers and the preparation of block polymer materials, and achieves reduction of toxic side effects, high drug loading, and biocompatibility. Good results
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[0023] ①Preparation of star block copolymer
[0024] Using L-lactide as the raw material, the three-arm or multi-arm star polylactic acid was synthesized by the classic stannous octoate catalyzed ring-opening method. Due to the presence of the hydroxyl group at the end of the polymer, it was in an ice bath with bromoisobutyryl bromide. In the middle reaction, the star-shaped macroinitiator SPLA-Br with bromine terminal functional group was obtained. The macroinitiator and DMA are subjected to ATRP polymerization in a certain proportion to obtain a star-shaped block polymer with PLA as the core PDMA.
[0025] ②Characterization of the self-assembled structure and properties of star-shaped block copolymer materials
[0026] The chemical structure and morphological characteristics of polymers are the basis for studying various properties of polymers. This subject intends to use Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Reso...
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