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A kind of self-emulsifying soft capsule of traditional Chinese medicine composition for treating common cold and preparation method thereof

A technology of self-emulsifying soft capsules and compositions, which is applied in the direction of drug combination, pharmaceutical formula, capsule delivery, etc., to achieve the effect of simple method, good stability and enhanced compliance

Active Publication Date: 2019-02-15
SHANDONG LUOXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

SMEDDS belongs to thermodynamically stable system, stable in property, there is no report on developing the prescription oral preparation of the present invention with self-microemulsification technology at present

Method used

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  • A kind of self-emulsifying soft capsule of traditional Chinese medicine composition for treating common cold and preparation method thereof
  • A kind of self-emulsifying soft capsule of traditional Chinese medicine composition for treating common cold and preparation method thereof
  • A kind of self-emulsifying soft capsule of traditional Chinese medicine composition for treating common cold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Extraction of volatile oil by steam distillation

[0057] Forsythia 4000g Notopterygium 2000g Mint 2000g

[0058] The volatile oil of forsythia, notopterygium and peppermint was extracted by steam distillation, the amount of water added was 6 times the weight of the medicinal materials, and the extraction time was 6 hours; 160 g of volatile oil was obtained and set aside.

[0059] 2. Preparation of self-emulsifying soft capsules

[0060] Contents Prescription:

[0061]

[0062] Preparation Process:

[0063] 1. Take the volatile oil, add MCT and mix well to get the oil phase;

[0064] 2. Add Tween 85 and Polyethylene Glycol 400 for grinding and mixing, stir in a constant temperature water bath at 30°C at a speed of 35rpm for 1.5h to dissolve completely, and obtain an emulsified phase;

[0065] 3. Mix the oil phase with the emulsified phase, ultrasonically vibrate at 30°C, and mix well to form a self-emulsifying concentrate;

[0066] 4. Weigh gelatin, glycerin,...

Embodiment 2

[0069] 1. CO 2 Supercritical extraction of volatile oil

[0070] Forsythia 4000g Notopterygium 2000g Mint 2000g

[0071] Grind forsythia, notopterygium and mint into 20-mesh granules, CO 2 Supercritical extraction, at extraction pressure 25MPa, extraction temperature 60°C, CO 2 Extract at a flow rate of 30 L / h for 1.5 hours, separate and collect the volatile oil; obtain 240 g of volatile oil for future use.

[0072] 2. Preparation of self-emulsifying soft capsules

[0073] Contents Prescription:

[0074]

[0075] Preparation Process:

[0076] 1. Take the volatile oil, add ethyl oleate and mix well to get the oil phase;

[0077] 2. Add Tween 80 and 1,2-propanediol for grinding and mixing, stir in a constant temperature water bath at 30°C at a speed of 35rpm for 1.5h to dissolve completely, and obtain an emulsified phase;

[0078] 3. Mix the oil phase with the emulsified phase, ultrasonically vibrate at 30°C, and mix well to form a self-emulsifying concentrate;

[007...

Embodiment 3

[0082] 1. Extraction of volatile oil by steam distillation

[0083] Forsythia 3000g Notopterygium 1000g Mint 3000g

[0084] The volatile oil of forsythia, notopterygium and peppermint was extracted by steam distillation, the amount of water added was 6 times the weight of the medicinal materials, and the extraction time was 6 hours; 140 g of volatile oil was obtained and set aside.

[0085] 2. Preparation of self-emulsifying soft capsules

[0086] Contents Prescription:

[0087]

[0088] Preparation Process:

[0089] 1. Take the volatile oil, add ethyl oleate and mix well to get the oil phase;

[0090] 2. Add Tween 85 and isopropanol for grinding and mixing, and stir in a constant temperature water bath at 35°C at a speed of 40rpm for 2 hours to completely dissolve it to obtain an emulsified phase;

[0091] 3. Mix the oil phase with the emulsified phase, ultrasonically vibrate at 35°C, and mix well to form a self-emulsifying concentrate;

[0092] 4. Weigh gelatin, glyc...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition self-emulsifying soft capsule used for treating cold, and a preparation method thereof. According to the preparation method, fructus forsythia, Rhizoma et Radix Notopterygii, and mint are weighed according to a certain ratio, and volatile oil of the three ingredients is extracted, and is mixed with grease, an emulsifying agent, and a co-emulsifier so as to obtain a self-microemulsifying concentrated solution; and the traditional Chinese medicine composition self-emulsifying soft capsule is prepared via a conventional method. The preparation method is simple; oral absorption effect can be improved; curative effect is exact and safe; stability is high; and quality is controllable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a self-emulsifying soft capsule of a traditional Chinese medicine composition for treating colds and a preparation method thereof. Background technique [0002] Viral influenza is a respiratory disease caused by multiple influenza viruses, and is an infectious disease that seriously threatens people's health, so it is also called influenza (flu). Influenza is a common acute respiratory infectious disease. The disease is highly contagious and has a sudden onset. It often causes local or even global epidemics. About 3 to 5 million people in the world are infected with influenza-like diseases every year, and the number of deaths due to influenza is about There are 250,000-500,000. The harm of influenza mainly contains: 1) because influenza virus is very easy to mutate, therefore in all parts of the world, every year there will be large or small epidemics in scope, and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/634A61P11/00A61P31/16A61P11/04A61P11/02
Inventor 王军周丙阳毛慧慧
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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