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Application of azithromycin in preparing anti-fatigue and anti-disease drug

Azithromycin, anti-fatigue technology, applied in the field of medicine

Inactive Publication Date: 2015-10-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the anti-fatigue effect of the macrolide antibiotic azithromycin

Method used

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  • Application of azithromycin in preparing anti-fatigue and anti-disease drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 Anti-fatigue activity research

[0014] 1. Materials and methods

[0015] (1) Reagents

[0016] Chinese name English name Company

[0017] Azithromycin Azithromycin Zhejiang Jinhua Pharmaceutical

[0018] Hydroxymethyl Cellulose Sodium CMC-Na Sinopharm

[0019] (2) Main solution configuration

[0020] 1. 0.8% sodium hydroxymethylcellulose solution

[0021] Reagent name Dosage

[0022] Sodium hydroxymethylcellulose 0.8g

[0023] Single distilled water 1000ml

[0024] 2. Azithromycin suspension (orally administered to mice)

[0025] Reagent name Dosage

[0026] Azithromycin 0.01g

[0027] CMC-Na solution 0.8ml

[0028] (3) Experimental animals

[0029] Animal breeding: C57 mice, male, 18-22 g, were obtained from the Experimental Animal Center of Second Military Medical University. During the experiment, the temperature of the animal room was stable at about 22 degrees, the relative humidity was 70%, and the lighting time was from 8:00 a.m. to 8:0...

Embodiment 2

[0042] Example 2 Effects on Biochemical Indexes of Mice After Exercise

[0043] 1. Materials and methods

[0044] 1. Reagents and Experimental Animals

[0045] As in Example 1, 80 experimental mice were randomly divided into 2 batches, and the experiments of measuring serum urea nitrogen, blood lactic acid, hemoglobin, lactate dehydrogenase and liver glycogen were carried out respectively. Each batch of animals is divided into 4 groups, respectively, azithromycin low-dose group, azithromycin middle-dose group, azithromycin high-dose group and control group, 10 animals in each group, respectively according to azithromycin 5mg / kg, azithromycin 15mg / kg, azithromycin 60mg / kg The dose of kg was given by intragastric administration, and the control group was given the same dose of CMC-Na solution. The mice were kept under normal light, drinking water, and fed at 25°C. Oral gavage once a day, the amount of gavage is 1% of the mass of the mice, and the indicators are measured after ...

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Abstract

The invention relates to the application of azithromycin in preparing an anti-fatigue and anti-disease drug. The application has the advantages that the anti-fatigue effect of the macrolide antibiotics azithromycin is discovered for the first time; an animal experiment result shows that the azithromycin can significantly prolong the swimming time of a loaded mouse, lower the serum urea ammonia level after strenuous exercise, restrain rising of blood lactic acid, maintain or increase the content of hemoglobin, enhance the activity of lactic dehydrogenase, increase the storage amount of hepatic glycogen and reduce the consumption of hepatic glycogen in exercise and has the significant effects of relieving fatigue and improving exercise tolerance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of azithromycin, a macrolide antibiotic, in the preparation of fatigue-resistant medicine. Background technique [0002] Macrolides are a class of basic lipophilic antibiotics with twelve- to twenty-membered rings. Among them, erythromycin is its classic representative drug. Clinical and experimental studies have found that erythromycin is the most effective and safe drug for the treatment of Legionnaires' disease. In addition, it is also effective in some other bacterial infections, such as Helicobacter pylori. More and more reports have recently found that macrolide compounds are not only an antibiotic, but also have other biological activities: research has found that fourteen-membered ring derivatives (erythromycin, roxithromycin, carat erythromycin) can stimulate the proliferation of monocyte / macrophage stem cells; Anssers found that erythromycin can acce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7052A61P39/00A23L1/29
Inventor 苏定冯刘霞雷虹孙旸
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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