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Medicinal composition for treating acute renal failure

A technology of acute renal failure and composition, applied in the field of pharmaceuticals, can solve the problems of inability to treat chronic renal failure, inability to treat acute renal failure, etc.

Inactive Publication Date: 2007-12-12
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Those of ordinary skill in the art know that conventional drugs for the treatment of acute renal failure, such as arsenic trioxide injection, etc., cannot treat chronic renal failure; and drugs for the treatment of chronic renal failure, such as Shenqi Dihuang Decoction, cannot treat acute renal failure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 8

[0099] Example 8: Extraction and separation to prepare a large-volume injection

[0100] 150g of Ligusticum chuanxiong, 150g of Epimedium, 200g of Angelica, 150g of Alisma orientalis and 70wt.% ethanol were soaked in a multifunctional extraction tank overnight. Reflux and extract twice, 1.5 hours each time, filter to obtain drug residue I and drug solution I, retain the drug residue I, place the drug solution I in a vacuum concentration pot, and concentrate to obtain concentrated solution A (80°C, d=1.10), Affix the label, indicating the product name, batch number, date, etc.

[0101] Add 400g of Astragalus, 200g of raw land, and 150g of Poria cocos to 3200ml of water for injection soak for 1 hour, add the above reserved medicine residue I, add 3200ml of water for injection and decoct twice for 1.5 hours each time, filter, combine the filtrate, discard the medicine residue, and combine Place the liquid in a three-effect concentrator, stop the concentration when the specific gravit...

Embodiment 9

[0104] Add 200g of Ligusticum chuanxiong, 150g of Epimedium, 220g of Angelica, 150g of Rhubarb with 70wt.% ethanol in a multifunctional extraction tank and soak overnight. Reflux extraction twice, each time for 2.0 hours, filter to obtain drug residue I and drug solution I, retain drug residue I, place the drug solution I in a vacuum concentration pot, and concentrate to obtain concentrated solution A (80°C, d=1.10), Affix the label, indicating the product name, batch number, date, etc.

[0105] Add 450g of Astragalus, Radix 205g, 185g of Poria cocos, 155g of Radix Paeoniae Rubra, 185g of Alisma, and 5g of Panax notoginseng to 3200ml of water for injection and soak for 1 hour, add the above-mentioned retained medicine residue I, add 3200ml of water for injection and decoct twice for 1.5 hours each time. Filter, combine the filtrate, discard the dregs, put the combined solution in a three-effect concentrator, stop the concentration when the specific gravity is 1.12, let it cool to ...

Embodiment 10

[0107] Example 10: Preparation of 20ml freeze-dried powder injection

[0108] (1) Take 200g of Ligusticum chuanxiong, 185g of Epimedium, 200g of Angelica and 150g of Rhubarb, 7 times the total weight of the above components, 60wt.% ethanol, heat reflux for extraction 2 times, each time for 2.0 hours, filter to obtain medicine residue I and medicine Liquid I, keep medicine residue I.

[0109] (2) Add 450g of Astragalus, 15g of raw rehmannia, 100g of Poria cocos, 155g of Radix Paeoniae Alba, 15 of Alisma, 75g of Panax notoginseng to 3200ml of water for injection and soak for 1 hour, add the above-mentioned reserved medicine residue I, add 3200ml of water for injection and decoct twice, each time After 1.5 hours, filter and combine the filtrate to obtain an extraction composition. Take 10g of the extract composition, add an appropriate amount of water for injection to dissolve, add 2.25g of sodium chloride, adjust the volume to 250ml with the water for injection, add an appropriate a...

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PUM

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Abstract

The invention relates to the use of a group of Chinese medicinal compositions in treating acute kidney failure and / or enhancing immunity, wherein the medicinal composition comprises the following raw materials (by weight portion): rhizome of Sichuan lovage 15-200 weight parts, astragalus root 40-450 weight parts, Chinese angelica root 20-220 weight parts, epimedium 15-185 weight parts, dried rehmannia root 15-205 weight parts, alisol 15-185 weight parts and poria cocos wolf 15-185 weight parts.

Description

Technical field [0001] The present invention relates to a type of pharmaceutical composition, its preparation method and its use, in particular to its use in the pharmaceutical field. Background technique [0002] Acute renal failure refers to a type of acute uremic syndrome in which renal function is damaged due to various reasons, and blood urea nitrogen, creatinine rises, and water and electrolyte disorders occur. Its cause: Acute hypovolemia and peripheral circulatory failure caused by various reasons. Mainly: (1) Toxic substances, the body's immune response to drugs, and serious damage to the kidneys caused by infections or diseases such as acute glomerulonephritis, causing it to fail; (2) Sudden decrease in blood pressure during severe burns, severe Bleeding (for example, suffering from squeezing trauma), or having a heart attack, etc. leads to abnormal blood supply and severe damage to the kidneys; (3) An obstruction in a certain part of the urinary tract makes the flow of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P13/12
Inventor 孙虹解荷芝陈剑胡菊华陈春贵
Owner LIVZON PHARM GRP INC
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