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Method for extracting volatile oil and magnolol from mangnolia officinalis leaves

A technology of volatile oil and magnolol, which is applied in the field of extraction of active ingredients of plants, can solve the problems of toxicity, high cost of factory production, cumbersome extraction process, etc., and achieve the effect of short time consumption, low cost and easy purification treatment

Active Publication Date: 2015-10-21
SHAANXI SCI TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methanol, the main extraction medium used in this method, has caused a toxic and harmful working environment, and there are also disadvantages of cumbersome extraction process and high cost of factory production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dry Magnolia officinalis leaves in the shade, pulverize, pass through a 100-mesh sieve, and then complete the extraction of Magnolia officinalis volatile oil and magnolol according to the following steps:

[0019] 1) Weigh 40kg of Magnolia officinalis leaf powder and put it into a distillation tank, feed water vapor for distillation for 1.2h under stirring, and receive the liquid that slips out of the whole process from the condenser tube,

[0020] 2) The effluent was extracted three times with 30°C-60°C model petroleum ether, the amount of petroleum ether used in each extraction was 0.7 times the volume of the effluent, and the extracts were combined,

[0021] 3) drying the extract with anhydrous sodium sulfate, then distilling and recovering petroleum ether to obtain 0.72kg Magnolia officinalis volatile oil;

[0022] 4) After completing step 1), continue to stir the water and solid slag in the distillation tank, cool down to normal temperature naturally, add slaked li...

Embodiment 2

[0029] Take Magnolia officinalis leaves 100 order powder 60kg, put into retort, then complete the extraction of Magnolia officinalis volatile oil and magnolol according to the following steps:

[0030] 1) Distillate with water vapor for 1 hour under stirring, and receive the liquid that slips out from the condenser tube during the whole process,

[0031] 2) The effluent was extracted three times with 30°C-60°C model petroleum ether, and the amount of petroleum ether used in each extraction was 1 times the volume of the effluent, and the extracts were combined,

[0032] 3) dry the extract with anhydrous sodium sulfate, then distill and recover petroleum ether to obtain 0.96kg Magnolia officinalis volatile oil;

[0033] 4) After completing step 1), continue to stir the water and solid slag in the distillation tank, cool down to normal temperature naturally, add slaked lime, adjust pH=9, stir for 40min, release the material, filter,

[0034] 5) The filter residue of step 4) is l...

Embodiment 3

[0040] Take Magnolia officinalis leaves 100 order powder 80kg, put into retort, then complete the extraction of Magnolia officinalis volatile oil and magnolol according to the following steps:

[0041] 1) Distillate with water vapor for 1 hour under stirring, and receive the liquid that slips out from the condenser tube during the whole process,

[0042] 2) The effluent was extracted three times with 30°C-60°C model petroleum ether, the amount of petroleum ether used in each extraction was 0.7 times the volume of the effluent, and the extracts were combined,

[0043] 3) drying the extract with anhydrous sodium sulfate, then distilling and reclaiming sherwood oil to obtain 1.36kg Magnolia officinalis volatile oil;

[0044] 4) After completing step 1), stir the water and solid slag in the distillation tank, cool down to normal temperature naturally, add slaked lime, adjust pH=10, continue stirring for 30min, release the material, filter,

[0045] 5) The filter residue of step 4...

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PUM

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Abstract

The invention discloses a method for extracting volatile oil and magnolol from mangnolia officinalis leaves. First, mangnolia officinalis leaf powder is placed in a distilling tank for steam distillation, the mangnolia officinalis volatile oil is extracted, then the magnolol is extracted by the following steps that 1. water and solid residues in the distilling tank are stirred, slaked lime is added, pH is adjusted to 9-10, stirring is carried out continuously for 30-40 min, and filtering is carried out; 2. filter residues are subjected to normal-temperature digestion by two times with lime water with pH of 9-10, the extracting liquid is combined, concentrated hydrochloric acid is used for adjusting pH of the extracting liquid to be 3-4, standing and settling are carried out, water is used for washing until neutral is achieved, constant temperature drying is carried out under the temperature of 45 DEG C, and crude extract is obtained; and 3. the crude extract and silica gel with four-time amount are mixed, petroleum ether is used for reflux extraction, extracting liquid is concentrated, cooling is carried out, after complete precipitation crystallization, filtering is carried out, and then an ethyl acetate and petroleum ether mixed solution is used for recrystallization. Comprehensive extracting of two effective components in the mangnolia officinalis leaves is achieved, the process is simple, cost is low, the extracting rate is high, and environment-protecting industrialized production can be achieved.

Description

technical field [0001] The invention relates to a method for extracting effective plant components, in particular to a method for extracting volatile oil and magnolol from Magnolia officinalis leaves. Background technique [0002] Magnolol is a drug with significant physiological activity. It has anti-inflammatory, antibacterial, anti-pathogenic microorganism, anti-ulcer, anti-oxidation, anti-tumor, can inhibit morphine withdrawal reaction and inhibit platelet aggregation, etc. It is mainly used clinically as It is widely used in medicines for eliminating fullness in the chest and abdomen, calming the central nervous system, relaxing muscles of athletes, antifungal, and antiulcer, etc. For a long time, magnolol is mainly extracted from the dry bark, root bark and branch bark of Magnolia officinalis Rehd et Wils. Hackberry bark needs to grow for about 20 years to meet the medicinal quality requirements. Magnolia officinalis grows slowly, and the production cycle of medicinal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02C07C39/21C07C37/70C07C37/76C07C37/72
Inventor 刘存芳田光辉陈亮吴迎春张志军王俊宏葛红光赖普辉任晓峰王平
Owner SHAANXI SCI TECH UNIV
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