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Medicine for treating acne vulgaris and preparation method thereof

A common and pharmaceutical technology, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as easy to leave depressed scars, unacceptable by patients, unsatisfactory effects, etc., to achieve suitable taste and improve Immunity, the effect of not easy to relapse

Inactive Publication Date: 2015-10-07
吴强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the current traditional Chinese medicine and western medicine treatment of acne vulgaris, there are many side effects, long course of treatment, unsatisfactory effect, unacceptable to patients, and easy to leave depressed scars, which affect the appearance

Method used

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  • Medicine for treating acne vulgaris and preparation method thereof
  • Medicine for treating acne vulgaris and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0081] Wherein, the dosage form of described internal medicine is capsule, and its preparation method comprises:

[0082] First crush the raw material drug for oral administration into a coarse powder, then further crush it, and pass through a 100-120 mesh sieve, so that the amount of fine powder that can pass through the sieve reaches more than 30%, and collect the fine powder that passes through the sieve to obtain fine powder a; Put the coarse powder that cannot pass through the 120-mesh sieve into a multi-functional extraction tank for extraction twice, first add 5-10 times the amount of ethanol to extract for 1-2 hours, and add 4-8 times the amount of water to decoct for 1-2 hours for the second time , combine the two decoctions, filter to obtain the filtrate; heat and concentrate to a paste, put it in an oven at 80°C, dry it, cool it, grind it into a fine powder b, mix a and b, and put it into a capsule.

[0083] Wherein, when the dosage form of the medicine for internal...

experiment example 2

[0127] Experimental example 2: long-term toxicity test data

[0128] 1. Experimental method

[0129] The guinea pigs were randomly divided into 4 groups, 15 in each group. Apply the depilatory agent evenly on both sides of the back spine of the guinea pig, so that the range of depilation is about 40 square centimeters. Wash off the depilatory agent, and after 24 hours of observation, each group of guinea pigs is respectively coated with 0.2, 0.4 and 0.8ml of the externally administered drug liniment of the present invention, containing 92, 184 and 368mg of crude drug respectively, and another group is coated with 0.8ml of solvent twice a day, continuously After 30 days, the general condition of the guinea pigs was observed. After the experiment, the animals were sacrificed for hematology, blood biochemical and pathological examinations.

[0130] 2. Results

[0131] No edema, hyperemia, erythema, bleeding spots and ulcers were found in the depilated trunk area of ​​guinea...

experiment example 3

[0132] Experimental example 3: Cumulative toxicity test:

[0133] Drug oral tablet of the present invention is to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: medicine of the present invention is effective on rats. Hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators had no significant impact, and no abnormal changes were found in the organs with the naked eye, and the results of histological examination showed that after 15 weeks of medication and withdrawal After 3 weeks, there was no obvious change in the organs of the rats. It shows that the drug capsule for oral administration of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

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Abstract

The invention discloses a medicine for treating acne vulgaris and a preparation method thereof. The medicine for treating acne vulgaris comprises an orally taken medicine and an externally applied medicine, wherein the orally taken medicine is prepared from the following raw materials: schizonepeta, lithospermum, divaricate saposhnikovia root, hawksbill, honeysuckle, scutellaria baicalensis, duckweed, long stephania herb, meadowrue root and rhizome, wild buckwheat, lysimachia congestiflora, patrinia, malt, belvedere fruit, Chinese quince fruit and rhizoma dryopteris crassirhizomae. The medicine for treating acne vulgaris has the beneficial effects that the medicine for treating acne vulgaris has the effects of clearing away the lung heat and dispelling wind and clearing heat and toxic materials and is mainly used for treating acne vulgaris, medicinal materials of different properties are adopted, the compatibility is rigorous, the syndrome differentiation is realized, the pharmaceutical effect can be directly taken on a focus, the healing time is short, and recurrence is hardly caused after healing; meanwhile, a preparation technology is simple and convenient, toxic and side effects are small, the taste is appropriate, and thus a patient can accept the medicine for treating acne vulgaris easily; the medicine for treating acne vulgaris combines internal therapy and external therapy and is used for nourishing from inside to outside and treating both symptoms and root causes, the orally taken medicine and the externally applied medicine are promoted each other, the autoimmunity is improved, no side effect is produced to a human body, the safety and efficiency are realized, and the aims of treating a disease and strengthening a body are achieved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a medicine for treating acne vulgaris and a preparation method thereof. Background technique [0002] Acne vulgaris (acne vulgaris) is a common chronic pilosebaceous gland inflammatory disease in adolescence, which often occurs on the face and is often accompanied by seborrhea. The disease is self-limiting and resolves spontaneously in adulthood. The onset is mostly in adolescence, and the onset age of women is often earlier than that of men, which can be half a year to one year before menarche. The damage mainly occurs on the face, especially the forehead, cheeks, and chin, followed by the chest, back, and shoulders. It is acne at first, and there are two kinds of whiteheads and blackheads, which contain keratin and sebum. Whiteheads, also known as closed comedones, are skin-colored papules, hour-sized, obvious under the opening of the hair follicle, and...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61K36/87A61P17/10A61K35/586A61K35/64
Inventor 吴强
Owner 吴强
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