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Titanium-niobium-zirconium-based calcium pyrophosphate biological composite material preparation method

A technology of titanium-niobium-zirconium-based calcium pyrophosphate and niobium-zirconium-based calcium pyrophosphate, which is applied in the field of preparation of titanium-niobium-zirconium-based calcium pyrophosphate biocomposite materials, can solve the problems of hindering bone tissue growth, healing, easy falling off of surface composite materials, The problem of high elastic modulus of composite materials, to achieve the effect of improving biocompatibility, low elastic modulus and high compressive strength

Active Publication Date: 2015-09-09
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the existing problems of the current biocomposite materials, such as the surface composite material is easy to fall off, the stability is poor, the composite material prepared by mixing has a high elastic modulus, and the stress shielding phenomenon is easy to occur, etc., and provides a titanium alloy-based calcium pyrophosphate biocomposite The preparation method of the material; the purpose is to further improve the mechanical activity of artificial implants, and solve the problems of bone stress shielding, hindering bone tissue growth and healing caused by the mismatch between the elastic modulus and mechanical properties of implants and bone tissue

Method used

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  • Titanium-niobium-zirconium-based calcium pyrophosphate biological composite material preparation method
  • Titanium-niobium-zirconium-based calcium pyrophosphate biological composite material preparation method
  • Titanium-niobium-zirconium-based calcium pyrophosphate biological composite material preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0026] (1) According to the mass percentage (wt%) of Ti 74%, Nb 13%, and Zr 13%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99% and a particle size of 45 μm ;Put the metal powder into the ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 4:1, sealed with alcohol, then vacuumed to 30Pa, and then ball milled for 10 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0027] (2) Weigh 25% of the mass of the mixed metal powder obtained in step (1) to take the analytically pure product with a purity of 96%, add it to the mixed metal powder for ball milling, seal with alcohol and vacuumize at 20Pa, and mix for 150min , and then dried in a vacuum oven at 40°C for 4h (dry until it is agitated with a glass rod, and it can be powdered).

[0028] (3) Put the mixed powder obtained in step (2) into a graphite mold,...

Embodiment 2

[0035] 1) According to the mass percentage (wt%) of Ti 73%, Nb 25%, and Zr 2%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99%, and a particle size of 30 μm; The metal powder is put into a ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 3:1, sealed with alcohol and then vacuumed to 20Pa, and then ball milled for 12 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0036] (2) Weigh 30% of the mass of the mixed metal powder obtained in step (1) to take the analytically pure product with a purity of 96%, add it to the mixed metal powder for ball milling, seal it with alcohol and vacuumize it to 20Pa, and mix for 200min , and then dried in a vacuum oven at 40°C for 4h (dry until it is agitated with a glass rod, and it can be powdered).

[0037] (3) Put the mixed powder obtained in step (2) into a graph...

Embodiment 3

[0044] (1) According to the mass percentage (wt%) of Ti 76%, Nb 18%, and Zr 6%, respectively weigh Ti, Nb, and Zr metal powders with a purity of 99.5%, 99.95%, and 99%, and a particle size of 25 μm; The metal powder is put into a ball mill jar for mechanical alloying. During the ball milling process, the ball milling medium is stainless steel balls, the ball-to-material ratio is 3:1, sealed with alcohol and then vacuumed to 20Pa, and then ball milled for 11 hours, the obtained metal mixed powder is still placed in alcohol for later use.

[0045] (2) Weigh 35% of the mass of the mixed metal powder obtained in step (1) and weigh the analytically pure product with a purity of 96%, add it to the mixed metal powder for ball milling, seal with alcohol and vacuumize at 25Pa, and mix for 180min , and then dried in a vacuum oven at 40°C for 4.5h (dried until it was stirred with a glass rod and turned into powder).

[0046] (3) Put the mixed powder obtained in step (2) into a graphite ...

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Abstract

The present invention discloses a titanium-niobium-zirconium-based calcium pyrophosphate biological composite material preparation method, and belongs to the technical field of biomedical material preparation, wherein the biological composite material comprises a titanium-niobium-zirconium alloy matrix phase and a calcium pyrophosphate bioactive additive phase. The preparation method comprises: weighing Ti powder, Nb powder and Zr powder according to a component ratio, carrying out ball milling mechanical alloying, and then adding calcium pyrophosphate to carry out ball milling powder mixing; placing into a discharge plasma sintering furnace, applying 50-60 MPa axial pressure, and sintering under a vacuum degree of 15-20 Pa; and carrying out thermal insulation for 10-15 min at a temperature of 950-1050 DEG C, and cooling along with the furnace to a room temperature so as to obtain the titanium-niobium-zirconium-based calcium pyrophosphate biological composite material. According to the present invention, the prepared titanium-niobium-zirconium-based calcium pyrophosphate biological composite material has characteristics of low elastic modulus (38-65 GPa) and high compactness (more than or equal to 95%); the structure contains a large amount of the bioactive ceramic phase so as to easily induce cell growth and be used for human hard tissue replacement and repair, and the preparation method has characteristics of clean manufacturing process, simple process, low cost, and easy industrial production achieving.

Description

technical field [0001] The invention relates to a method for preparing a titanium-niobium-zirconium-based calcium pyrophosphate biocomposite material, in particular to a method for preparing a titanium alloy-based calcium pyrophosphate biocomposite material by using a spark plasma sintering technology, and belongs to the technical field of biomedical material preparation. Background technique [0002] Among the artificial biomedical metal materials currently used clinically, titanium and titanium alloys have excellent performance and a wide range of applications. Titanium and titanium alloys are considered to be the preferred materials for hard tissue replacement and repair such as artificial joints, spinal orthopedic internal fixation systems, and dental implants. Among them, the Ti-Nb-Zr alloy is a non-toxic and low elastic modulus β-type titanium alloy. There are many researches at home and abroad, including Ti-13Nb-13Zr, Ti-25Nb-2Zr, Ti-24Nb-4Zr -7.9Sn, etc. This series...

Claims

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Application Information

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IPC IPC(8): C22C1/05C22C14/00A61L27/42A61L27/50A61L31/12A61L31/14
Inventor 张玉勤何正员何远怀蒋业华周荣
Owner KUNMING UNIV OF SCI & TECH
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