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Compound traditional Chinese medicine aqueous extract for treating acute pancreatitis and preparation method thereof

A technology of acute pancreatitis and medicinal water extract, which is applied in the field of medicine and can solve problems such as poor efficacy

Inactive Publication Date: 2015-09-09
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical treatment, it was found that simple western medicine treatment is not effective in SAP with abdominal distension and intestinal paralysis

Method used

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  • Compound traditional Chinese medicine aqueous extract for treating acute pancreatitis and preparation method thereof
  • Compound traditional Chinese medicine aqueous extract for treating acute pancreatitis and preparation method thereof
  • Compound traditional Chinese medicine aqueous extract for treating acute pancreatitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Embodiment 1 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of water phase liquid is collected; the collected w...

Embodiment 2

[0161] Embodiment 2 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, Yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of aqueous phase liquid is collected; the collected...

Embodiment 3

[0162] Embodiment 3 of the present invention: take the water extract prepared in Embodiment 2 and pass through an 80-mesh sieve, add appropriate amount of dextrin and lactose, mix evenly according to the equal multiplication method, add HPMC solution to make soft material, granulate, dry, and prepare granules, divided into capsule shells to obtain capsules. The preparation is taken orally, 2-3 times a day, and the dose of each dose is 300-800 mg based on the active extract.

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Abstract

The invention discloses a compound traditional Chinese medicine aqueous extract for treating acute pancreatitis. The preparation raw materials of compound traditional Chinese medicine aqueous extract for treating acute pancreatitis comprise, by weight, 22-27 parts of gardenias, 22-27 parts of cortex moutan, 22-27 parts of costusroots, 22-27 parts of cortex magnoliae officinalis, 22-27 parts of corydalis yanhusuo, 35-45 parts of red peony roots, 35-45 parts of rhubarb and 12-17 parts of mirabilite. According to the compound traditional Chinese medicine aqueous extract for treating acute pancreatitis, eight traditional Chinese medicine compounds are selected to be used as the preparation raw materials. The aqueous extract obtained through preparation is applied to drugs for treating acute pancreatitis. As is proved by the experiment of the prepared drug, abdominal distension and intestinal paralysis can be remarkably relieved during severe acute pancreatitis (SAP), and therefore SAP symptoms can be remarkably relieved. Complications are reduced, and the death rate is reduced. According to treatment and summaries on more than 5000 cases of acute pancreatitis patients and more than 1000 cases of SAP patients, a good curative effect is achieved, the SAP cure rate can reach 85.4%, and the death rate is reduced to 10.1%. The source of the materials of the compound traditional Chinese medicine aqueous extract for treating acute pancreatitis is wide, the materials can be obtained easily, and cost is low. The adopted preparation method is simple and easy to implement and facilitates industrialization.

Description

technical field [0001] The invention relates to a medicine, in particular to a compound Chinese medicinal water extract for treating acute pancreatitis and a preparation method thereof. Background technique [0002] Acute pancreatitis (SAP) is an inflammatory reaction in which pancreatic tissue is digested, edema, hemorrhage, and even necrosis after activation of pancreatic enzymes due to various causes. Clinically, it is characterized by acute epigastric pain, nausea, vomiting, fever, and increased blood trypsin. The degree of lesion varies from severity to severity. In mild cases, pancreatic edema is the main symptom, which is more common in clinical practice. The condition is often self-limited and the prognosis is good. It is also called mild acute pancreatitis. Pancreatic hemorrhage and necrosis in a small number of severe cases is often followed by infection, peritonitis and shock, etc., and the fatality rate is high, which is called severe acute pancreatitis. Clinic...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/18A61K33/04
Inventor 兑丹华蔡治方田飞王後兰天罡
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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