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Epidermal anesthesia gel and preparation method thereof

A gel and epidermis technology, which is applied in anesthetics, aerosol delivery, liquid delivery, etc., can solve problems such as pH value hindrance and difficulty in coating, and achieve the effects of fast onset of action, reduced drug burden, and excellent performance

Inactive Publication Date: 2015-08-12
HUBEI HUIRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no tetracaine hydrochloride gel product in China before, and the gel matrix material of this product abroad uses carbomer, but carbomer hinders the control of the pH value of the gel, and another matrix material is carboxymethyl fiber However, sodium carboxymethyl cellulose is difficult to apply after gelling. In addition, the use of imported medicines causes economic burdens on the Chinese people, so how to produce this kind of anesthesia gel with the same or better effect, and in the preparation Simplifying the process and reducing the cost, thereby reducing the drug burden of the Chinese people is a problem that needs to be solved before

Method used

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  • Epidermal anesthesia gel and preparation method thereof
  • Epidermal anesthesia gel and preparation method thereof
  • Epidermal anesthesia gel and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] On the basis of the above, the thickener is specifically xanthan gum, and the pH regulator is specifically sodium hydroxide. In the formula of the epidermal anesthesia gel in the present invention, the weight percentage of each component is: tetracaine hydrochloride, 4.7 parts ; Xanthan gum, 2 parts; Sodium hydroxide, 0.6 parts; Purified water, 92.7 parts.

[0022] The epidermis anesthesia gel in the present invention can replace similar imported drugs, and has better effect, reduces the drug burden of Chinese people, has fast onset, small side effects, and wide application range. After a single administration, the anesthesia effect on most patients Up to 4-6 hours, long-term action. In this formula, xanthan gum is used as a thickener, which is easy to coat, and the pH is easy to control during the preparation process, easy to repeat, and the preparation process is stable. If sodium carboxymethyl cellulose is used as a thickener, the The gel is not uniform, it is diffi...

Embodiment 2

[0024] On the basis of the above, the thickener is specifically xanthan gum, and the pH regulator is specifically sodium hydroxide. In the formula of the epidermal anesthesia gel in the present invention, the weight percentage of each component is: tetracaine hydrochloride, 3 parts ; Xanthan gum, 1 part; Sodium hydroxide, 0.7 part; Purified water, 95.5 parts.

Embodiment 3

[0026] On the basis of the above, the thickener is specifically xanthan gum, and the pH regulator is specifically sodium hydroxide. In the formula of the epidermal anesthesia gel in the present invention, the weight percentage of each component is: tetracaine hydrochloride, 5 parts ; Xanthan gum, 3 parts; Sodium hydroxide, 0.5 parts; Purified water, 91.5 parts.

[0027] In this example, 5 parts of tetracaine hydrochloride are used. Generally, when the amount of tetracaine hydrochloride exceeds 4.7 parts, the absorption of tetracaine hydrochloride by the human body will increase, and the onset time and analgesic effect will not be affected.

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Abstract

The invention discloses epidermal anesthesia gel and a preparation method thereof. The epidermal anesthesia gel is composed of, by weight, 3-5 parts of tetracaine hydrochloride, 1-3 parts of thickener, 0.5-0.7 part of pH regulator and 92-95 parts of purified water, the thickener is xanthan gum, and the pH regulator is sodium hydroxide. The preparation method includes the following steps: adding the purified water into a mixing bucket, adding the pH regulator into the purified water, and stirring uniformly to form a solution a; mixing the thickener and tetracaine hydrochloride well, adding the thickener and tetracaine hydrochloride into the solution a in a stirring state, stirring until uniform paste is formed, and filling. The epidermal anesthesia gel can replace similar imported drug, has better performance, can lower medication burden of Chinese people and is quick in effect appearing, little in side effect, wide in using range, long in acting time, simple in preparation process, high in industrialized production efficiency and low in cost, and anesthesia effect on most patients can reach 4-6h after single dose.

Description

technical field [0001] The invention relates to the field of anesthetic drugs, in particular to an epidermal anesthetic gel and a preparation method thereof. Background technique [0002] Epidermal anesthesia refers to applying an anesthetic with strong penetrating power to the epidermis or mucous membrane to block the nerve endings located under the skin or mucous membrane through the epidermis or mucous membrane, so as to anesthetize the skin or mucous membrane. Epidermal anesthesia is simple and easy to perform, with high safety, can keep patients awake, has little interference with physiological functions, and has few complications. Epidermal anesthesia is suitable for superficial and limited small and medium-sized operations. [0003] Tetracaine hydrochloride, as an epidermal anesthetic preparation, was launched in the UK in 1996. It has a wide range of applications, has the characteristics of fast onset time, long duration of drug effect, strong anesthesia effect, con...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/245A61K47/36A61P23/02
Inventor 刘明胜
Owner HUBEI HUIRUI PHARMA
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