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X-ray developing thermotropic hydrogel and preparation method thereof

A hydrogel and X-ray technology, applied in the field of X-ray imaging thermotropic hydrogel and its preparation, can solve the problems of not obtaining amphiphilic block copolymer thermotropic hydrogel, etc., and achieve good injectability sexual effect

Active Publication Date: 2015-05-27
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the reports in the existing literature, this method can obtain a system with stable X-ray imaging properties, and the system has good biocompatibility, but so far no amphiphilic block copolymer with X-ray imaging properties has been obtained. Related reports on thermogenic hydrogels

Method used

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  • X-ray developing thermotropic hydrogel and preparation method thereof
  • X-ray developing thermotropic hydrogel and preparation method thereof
  • X-ray developing thermotropic hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Add 10.0 g of MPEG (550) into a 250 mL three-neck flask, heat the oil bath to 130°C, and vacuumize for 3 h while stirring to remove the moisture in MPEG, then add 21.0 g of D,L-lactide (LA) and 30 mg For stannous octoate (containing a small amount of toluene), the temperature of the oil bath was raised to 150°C, and the reaction was continued for 12 h under an argon atmosphere. After the reaction, vacuumize for 3 h to remove unreacted monomers and low-boiling products, dissolve the reaction product in dichloromethane and pour it out, precipitate it with ether, dissolve the precipitate in water and freeze-dry to obtain MPEG-PLA Diblock copolymer (Copolymer-1), the yield is about 90%, and it is stored at -20°C. The number-average and weight-average molecular weight ( M n , M w ) were 1770 and 2530, respectively, and the molecular weight distribution coefficient ( M w / M n ) is 1.43.

Embodiment 2

[0078] Add 20.0g PEG (1000) into a 250 mL three-neck flask, heat the oil bath to 130°C, vacuumize for 3 h while stirring, remove the moisture of PEG, then add 24.0 g D,L-lactide (LA), 4.5 g Glycolide (GA) and 50 mg stannous octoate (containing a small amount of toluene), the temperature of the oil bath was raised to 150 °C, and the reaction was continued for 12 h under an argon atmosphere. After the reaction is completed, vacuumize for 3 h to remove unreacted monomers and low-boiling products. Dissolve the reaction product in dichloromethane and pour it out. Precipitate with ether, then dissolve the precipitate in water and freeze-dry. The yield is about 85%. The product PLGA-PEG-PLGA triblock copolymer (Copolymer-3) was stored at -20°C. Measure the number average and weight average molecular weight ( M n , M w ) were 2830 and 3400, respectively, and the molecular weight distribution coefficient ( M w / Mn ) is 1.20.

Embodiment 3

[0080] Add 15.0 g of MPEG (550) into a 250 mL three-neck flask, and vacuumize for 3 h while stirring at 130 °C to remove the water contained therein. Add 25.0 g caprolactone (CL) and 60 mg stannous octoate (containing a small amount of toluene), and react at 120 °C for 24 h under an argon atmosphere. After the reaction, vacuumize for 3 h to remove unreacted monomers and low-boiling products, dissolve the reaction product in dichloromethane, pour it out, and precipitate it with ether. The yield is about 80%. The product MPEG-PCL diblock copolymer (Copolymer-5) was stored at -20°C. Measure the number average and weight average molecular weight ( M n , M w ) are 1890 and 2550, respectively, and the molecular weight distribution coefficient ( M w / M n ) is 1.35.

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Abstract

The invention belongs to the technical field of medical polymer materials and in particular relates to X ray developing thermotropic hydrogel and a preparation method thereof. The X ray developing thermotropic hydrogel comprises an iodine-containing amphiphilic block copolymer and a solvent, wherein the iodine-containing amphiphilic block copolymer is obtained by bonding an iodine-containing micromolecule and an amphiphilic block copolymer by virtue of a covalent bond, and thermotropic gelatinization phase transformation can be carried out on a water system of the X ray developing thermotropic hydrogel along with temperature increase. The thermotropic hydrogel can be implanted under the skin and implanted into an abdominal cavity, an articular cavity and other specific parts of a human body in a mode of injection, and in situ formed hydrogel has good X ray developing performance, clear positioning and long-term tracing observation can be carried out on the hydrogel by adopting an X ray radiography technique. The thermotropic hydrogel also can serve as a medicine controlled release carrier, a tissue repairing support, a blood vascular embolization agent, a tissue marker and the like and can be used for realizing integration of diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a type of X-ray imaging thermoinduced hydrogel and a preparation method thereof. Background technique [0002] Biomedical polymer materials have many advantages such as good biocompatibility and adjustable biodegradability, and are an important research direction for medical implant materials, especially in the fields of drug sustained release, soft tissue repair, and artificial organs. application value. In particular, the implantation process of thermotropic hydrogels based on amphiphilic block copolymers is mainly completed by injection. Convenient, minimally invasive, etc., and this kind of hydrogel also has the advantages of simple synthesis, mild conditions for embedding drugs, and adjustable structure and performance, so it has a good application prospect in the field of biomedicine. [0003] Medical implant materials generally need to be im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K47/34A61K9/06A61L27/18A61L27/52A61L27/50A61L31/06A61L31/18A61L31/16C08G81/00A61P9/14A61P35/00A61P7/02A61P7/04A61P35/04A61P1/00A61K47/10
Inventor 俞麟雷科文丁建东
Owner FUDAN UNIV
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