Cynanchum otophyllum saponin composition and application thereof

Abstract

The invention discloses a cynanchum otophyllum saponin composition. The cynanchum otophyllum saponin composition comprises cynanchum otophyllum saponin M1 and cynanchum otophyllum saponin M2, and the cynanchum otophyllum saponin M1 and the cynanchum otophyllum saponin M2 are combined at a mass ratio of 1:1. Tests show that the cynanchum otophyllum saponin composition can be taken orally and absorbed, can be used together with phenobarbital sodium, can be used for enhancing the antiepileptic effect of phenobarbital sodium, is superior to the single cynanchum otophyllum saponin M1 and the single cynanchum otophyllum saponin M2 in effect and can be prepared into an antiepileptic medicine.

Description

technical field [0001] The invention belongs to the field of active ingredients of ethnic medicines and antiepileptic compounds, and in particular relates to a combination of Qingyang ginseng saponins and its application in the preparation of antiepileptic drugs. Background technique [0002] Epilepsy, commonly known as "shorn wind" or "epilepsy", is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. There are about 9 million epilepsy patients in China, of which 5 to 6 million are active epilepsy patients. At the same time, about 400,000 new epilepsy patients are added every year. In China, epilepsy has become the second most common disease in neurology after headache. [0003] Qingyang ginseng ( Cynanchum otophyllum) is a commonly used ethnic medicine in the genus Evelvet, widely distributed in Southwest China, mainly for the treatment of epilepsy, vertigo, tinnitus, soreness of the waist and knees and other dis...

AI Technical Summary

Problems solved by technology

However, the traditional method takes a long time and is not efficient; the new method pays too much attention to or is limited to in vitro screening and computer virtual screening. However, some effective ingredients in vitro cannot be absorbed or inactivated after metabolism, and some ingredients are invalid in vitro and are inactive in vivo. Metabolic conversion into active ingredients, or through the neurohumoral system to exert drug effects, so in vitro screening cannot accurately and efficiently obtain the material basis of drug effects [Xiao Qiuyuan, Ma Chaoying. Research progress of serum medicinal chemistry in the physical basis of traditional Chinese medicine[J]. Shizhen National Medicine, 2009, 20(5): 1061-1062]

More importantly, the above research methods for screening and separating the active ingredients of traditional Chinese medicine have destroyed the systematic characteristics of the active ingredient group composed of multiple compounds in traditional Chinese medicine, leading to the common situation of "the more separated, the less effective"

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