Tablet containing ambroxol hydrochloride and salbutamol sulfate

A technology of albuterol sulfate and ambroxol hydrochloride, applied in the field of medicine, can solve the problems of affecting drug efficacy, easy mildew, poor bronchial effect and the like

Inactive Publication Date: 2015-05-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103251577A and CN103239431A relate to a tablet composition and a capsule composition of ambroxol hydrochloride and salbutamol sulfate respectively, but the amount of salbutamol sulfate in the two prescriptions is small, and the effect of dilating the bronchi is poor, thereby affecting its efficacy; CN102018694A relates to a Tablet capsules filled with ambroxol hydrochloride tablets and salbutamol sulfate tablets in the capsules can be absorbed after being taken by double disintegration of the capsule and the tablet, and the effect is poor; CN101204386B relates to a liquid of ambroxol hydrochloride and salbutamol sulfate Combination, but the liquid preparation has certain limitations, such as poor chemical stability, inconvenient storage and carrying, easy to mildew, rancidity, etc. This method adds stabilizers, pH regulators, sodium chloride, fragrances, and the prescription is complex and additives more

Method used

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  • Tablet containing ambroxol hydrochloride and salbutamol sulfate
  • Tablet containing ambroxol hydrochloride and salbutamol sulfate
  • Tablet containing ambroxol hydrochloride and salbutamol sulfate

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0011] Ambroxol Hydrochloride 7.5g

[0012] Salbutamol Sulfate 2.4g

[0013] Lactose 50.0g

[0014] Microcrystalline Cellulose 50.0g

[0015] Hypromellose 1.5g

[0016] Magnesium Stearate 1.0g

[0017] Makes 1000 pieces

[0018] Preparation:

[0019] The raw and auxiliary materials are respectively passed through a 100-mesh sieve, and set aside; take the prescribed amount of hypromellose, and make a 3% solution with purified water, set aside; take the prescribed amount of ambroxol hydrochloride and salbutamol sulfate and mix them uniformly in equal amounts; The mixture and the mixture of lactose and microcrystalline cellulose are uniformly mixed according to the equal addition method, and the soft material is made of 3% hypromellose solution, granulated with a 20-mesh sieve, and the wet granules are air-dried at 60°C for 2 hours, and dried The granules are passed through a 18-mesh sieve for granulation, and the prescribed amount of magnesium stearate is added to mix even...

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PUM

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Abstract

The invention provides a tablet containing ambroxol hydrochloride and salbutamol sulfate, and belongs to the technical field of medicines. The tablet provided by the invention mainly comprises the following auxiliary materials: a filler, a disintegrating agent, a lubricant and an adhesive. The tablet provided by the invention is capable of treating diseases of a respiratory system, such as acute and chronic bronchitis, asthmatic bronchitis and bronchial asthma; sputum is easy to cough up when trachea is expanded; the tablet is simple in prescription, and good in curative effect; and the preparation technology is suitable for industrialized mass production.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a tablet containing ambroxol hydrochloride and salbutamol sulfate. The invention provides a tablet which is safe, effective, stable in quality and convenient to carry and store for treating respiratory diseases such as acute and chronic bronchitis and asthma. Background technique [0002] Ambroxol hydrochloride is a mucolytic agent, which can improve the function of the respiratory mucosal tissue, increase the fluid volume of the respiratory tract and reduce the viscosity of the mucus. In addition, it can increase the movement of cilia and promote the secretion of pulmonary surfactant. These effects make the mucus easy to move , in conjunction with the lubrication of the respiratory wall, makes sputum easy to cough up. Salbutamol sulfate is a bronchodilator that selectively activates beta- 2 adrenergic receptors, and play a bronchodilator effect. with beta 2 The combination of ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/20A61K47/38A61K47/26A61P11/00A61P11/06
Inventor 王明刚任莉陈阳生孙桂玉汪泓
Owner CP PHARMA QINGDAO CO LTD
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