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Compound cefalexin capsule and preparation method thereof

A technology of cephalexin capsules and cephalexin, which is applied in directions such as capsule delivery, pharmaceutical formulations, and inactive medical preparations, can solve problems such as poor effects, and achieve the effects of large functional effects, low molecular weight, and good water solubility

Inactive Publication Date: 2015-05-13
SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically, it is not effective in treating respiratory bacterial infections accompanied by viscous sputum.

Method used

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  • Compound cefalexin capsule and preparation method thereof
  • Compound cefalexin capsule and preparation method thereof
  • Compound cefalexin capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0023] A compound cephalexin capsule, comprising the following raw material components:

[0024]

[0025] The preparation method steps are as follows:

[0026] (1) Screening of auxiliary materials: pass cephalexin, ambroxol, chitosan oligosaccharide, talcum powder, and starch through a 100-mesh sieve respectively;

[0027] (2) Ingredients: proportioning by weight is cephalexin (255 parts by weight), ambroxol (14 parts by weight), polacrilin potassium (70 parts by weight), oligochitosan (85 parts by weight), talcum powder (40 parts by weight) parts by weight), starch (60 parts by weight) for batching;

[0028] (3) Total mixing: cephalexin, ambroxol, polacrilin potassium, chitosan oligosaccharide, talcum powder, starch and water were boiled and stirred for 3.5 hours at a temperature of 100°C to form a paste mixture;

[0029] (4) Spray granulation: Introduce the pasty mixture in step (3) into the fluidized bed, carry out at an air pressure of 0.45MPa, a pump speed of a peris...

Embodiment 3

[0033] A compound cephalexin capsule, comprising the following raw material components:

[0034]

[0035] The preparation method steps are as follows:

[0036] (1) Screening of auxiliary materials: pass cephalexin, ambroxol, chitosan oligosaccharide, talcum powder, and starch through a 100-mesh sieve respectively;

[0037] (2) Ingredients: proportioning by weight is cephalexin (251 parts by weight), ambroxol (11 parts by weight), polacrilin potassium (60 parts by weight), oligochitosan (85 parts by weight), talcum powder (45 parts by weight) parts by weight), starch (60 parts by weight) for batching;

[0038] (3) Total mixing: add cephalexin, ambroxol, polacrilin potassium, chitosan oligosaccharide, talcum powder, starch and water to boil and stir for 2.5 hours at a temperature of 105°C to form a paste mixture;

[0039] (4) Spray granulation: Introduce the pasty mixture in the step (3) into the fluidized bed, carry out at an air pressure of 0.45MPa, a peristaltic pump spe...

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PUM

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Abstract

The invention relates to a compound cefalexin capsule and a preparation method thereof. The compound cefalexin capsule is prepared from the following raw materials in parts by weight: 220-270 parts of cefalexin, 2-20 parts of ambroxol, 25-125 parts of polacrilin potassium, 50-100 parts of chito-oligosaccharide, 5-50 parts of talc and 10-75 parts of starch. The compound cefalexin capsule is reasonable in formula, high in drug dissolution, simple in preparation method without pollution and remarkable in efficacy without adverse reaction.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound cephalexin capsule and a preparation method thereof. Background technique [0002] Cephalexin is a broad-spectrum β-lactam antibiotic, the first generation of oral cephalosporins, suitable for Gram-positive and negative cocci including Streptococcus pneumoniae, sensitive Staphylococcus aureus, Neisseria meningitidis, Neisseria gonorrhoeae Some cocci strains. Cefalexin has weak effect on Gram-negative bacilli, and a small number of Escherichia coli may still be sensitive at clinical concentrations. Insensitive pathogens include Streptococcus faecalis, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae, Proteus, Serratia, Enterobacter, and Pseudomonas aeruginosa, etc. drug resistance. The main mechanism of bacterial resistance to cephalexin is the production of β-lactamase. The bactericidal mechanism of cephalexin is t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/32A61K31/545A61K31/137A61P31/04A61P11/12
Inventor 齐鸿达刘俊华钱令
Owner SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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