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A kind of sustained-release capsule containing ibuprofen racemate or dextroform and preparation process thereof

A technology for sustained-release capsules and a preparation process, which is applied in the field of sustained-release capsules containing ibuprofen, can solve the problems of complex preparation process, unfavorable environmental protection, and unfavorable large-scale production of preparations, and achieves simple preparation process, complete drug release, and improved affinity. water-based effect

Active Publication Date: 2017-07-18
CHANGZHOU NO 4 PHARMA FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of this patented technology is relatively complicated, and it is necessary to use equipment and equipment that are not commonly used in preparation workshops such as decompression drying, which is not conducive to the industrialized production of preparations; the solvents used include ethanol, methanol, acetone, n-hexane, methylene chloride or their mixtures. Conducive to environmental protection

Method used

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  • A kind of sustained-release capsule containing ibuprofen racemate or dextroform and preparation process thereof
  • A kind of sustained-release capsule containing ibuprofen racemate or dextroform and preparation process thereof
  • A kind of sustained-release capsule containing ibuprofen racemate or dextroform and preparation process thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 ibuprofen sustained-release capsules

[0030] (1) Content prescription

[0031] Ibuprofen 300g

[0032] Lactose 100g

[0033] 1% sodium lauryl sulfate aqueous solution appropriate amount

[0034] (2) Slow-release coating layer

[0035]

[0036] Preparation Process:

[0037] (1) The ibuprofen is pulverized through a 100 mesh sieve, and the prescription amount is weighed to mix the ibuprofen and sieved lactose evenly, adding a 1% sodium lauryl sulfate aqueous solution to granulate, and passing through a 20 mesh sieve , dried at 40°C, passed through a 20-mesh sieve and granulated to obtain the contents of the capsule;

[0038] (2) filling the capsule contents prepared in step (1) into the capsule shell to obtain ibuprofen immediate-release capsules;

[0039] (3) Weigh ethyl cellulose and hydroxypropyl cellulose and add them to ethanol and stir until completely dissolved, add magnesium stearate and stir evenly to obtain a slow-releas...

Embodiment 2

[0041] The preparation of embodiment 2 ibuprofen sustained-release capsules

[0042] (1) Content prescription

[0043] Ibuprofen 300g

[0044] Mannitol 100g

[0045] 1% Tween 80 aqueous solution appropriate amount

[0046] (2) Slow-release coating layer

[0047]

[0048] Preparation Process:

[0049] (1) Ibuprofen is pulverized through a 100 mesh sieve, and the prescription amount is taken by weighing ibuprofen and mannitol that has been sieved and mixed evenly, adding mass volume percentage is 1% Tween 80 aqueous solution to granulate, crossing a 20 mesh sieve, 40 ℃ drying, passing through a 20-mesh sieve for granulation to obtain the contents of the capsule;

[0050] (2) filling the capsule contents prepared in step (1) into the capsule shell to obtain ibuprofen immediate-release capsules;

[0051] (3) Add ethyl cellulose and hydroxypropyl cellulose to ethanol and stir until completely dissolved, add magnesium stearate and stir evenly to obtain a slow-release coating ...

Embodiment 3

[0053] The preparation of embodiment 3 Dexibuprofen sustained-release capsules

[0054] (1) Content prescription

[0055] Dexibuprofen 300g

[0056] Sorbitol 100g

[0057] 1% aqueous solution of poloxamer

[0058] (2) Slow-release coating layer

[0059]

[0060]

[0061] Preparation Process:

[0062] (1) Dexibuprofen is pulverized through a 100-mesh sieve, and the recipe quantity is taken by weighing dextrobuprofen and sorbitol that has been sieved and mixed uniformly, adding a mass volume percentage of 1% poloxamer aqueous solution to granulate, passing 20-mesh sieve, dry at 40°C, pass through a 20-mesh sieve and granulate to obtain the contents of the capsule;

[0063] (2) filling the capsule contents prepared in step (1) into the capsule shell to obtain Dexibuprofen immediate-release capsules;

[0064] (3) Add ethyl cellulose and hydroxypropyl cellulose to ethanol and stir until completely dissolved, add magnesium stearate and stir evenly to obtain a slow-releas...

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Abstract

The invention discloses a slow-release capsule containing ibuprofen racemate or dextrorotatory body and a preparation process thereof. The slow-release capsule is composed of a capsule content, a capsule shell and a slow-release coating layer. The capsule content The preparation method is obtained by wet granulation by mixing ibuprofen and water-soluble filler, adding an aqueous solution containing surfactant, and wrapping the sustained-release coating layer on the capsule shell. The sustained-release capsule of the present invention has the advantages of stable and complete drug release and simple preparation process, and can be industrialized and mass-produced by using common equipment in a preparation workshop.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation, in particular to a slow-release capsule containing ibuprofen and a preparation process thereof. Background technique [0002] Ibuprofen is a white powder with a melting point of 74-77°C, very slightly soluble in water, and easily soluble in organic solvents such as ethanol and acetone. The molecular formula of the drug C 13 h 18 o 2 , molecular weight 206.28, chemical name is 2-(-4-isobutylphenyl) propionic acid, structural formula is as follows: [0003] [0004] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. At present, there are 13 dosage forms included in the non-prescription drug catalog in my country, and it is one of the OTC antipyretic and analgesic drugs wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/192A61K47/38A61K47/34A61K47/10A61K47/26A61P29/00
Inventor 范新华贺赟周岳宇朱季张翔屠永锐
Owner CHANGZHOU NO 4 PHARMA FACTORY
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