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Preparation method of compound danshen root thin film coated tablets

A technology of film coating and compound salvia miltiorrhiza, applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of coating layer thickness, splits, weight increase, etc., and achieve Good hydrophilicity, good bleeding and good adhesion

Active Publication Date: 2015-04-22
广西世彪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets
[0004] The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of compound salvia miltiorrhiza film-coated tablet:

[0027] 1) Raw material processing: Take 450g of Salvia miltiorrhiza, 141g of Panax notoginseng, 8g of borneol, ultrasonically extract Danshen 95% ethanol for 30 minutes, centrifuge, recover ethanol from the filtrate and concentrate it into a thick paste; Ethanol and concentrated into a thick ointment; the dregs were extracted with water and ultrasonic wave for 30 minutes, centrifuged, and the filtrate was concentrated into a thick ointment;

[0028] 2) Tablet pressing: Grind notoginseng into fine powder, make granules with the above-mentioned thick paste and auxiliary materials, dry, grind borneol into fine powder, mix with the above-mentioned granules, and press into 1000 plain tablets;

[0029] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the pot at 35-37°C, and use the continuo...

Embodiment 2

[0037] A kind of preparation method of compound salvia miltiorrhiza film-coated tablet:

[0038] 1) Raw material processing: Take 450g of Salvia miltiorrhiza, 141g of Panax notoginseng, 8g of borneol, ultrasonically extract Danshen 95% ethanol for 30 minutes, centrifuge, recover ethanol from the filtrate and concentrate it into a thick paste; Ethanol and concentrated into a thick ointment; the dregs were extracted with water and ultrasonic wave for 30 minutes, centrifuged, and the filtrate was concentrated into a thick ointment;

[0039] 2) Tablet pressing: Grind notoginseng into fine powder, make granules with the above-mentioned thick paste and auxiliary materials, dry, grind borneol into fine powder, mix with the above-mentioned granules, and press into 1000 plain tablets;

[0040] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pot at 35-37°C, and spray with intermi...

Embodiment 3

[0048] A kind of preparation method of compound salvia miltiorrhiza film-coated tablet:

[0049]1) Raw material processing: Take 450g of Salvia miltiorrhiza, 141g of Panax notoginseng, 8g of borneol, ultrasonically extract Danshen 95% ethanol for 30 minutes, centrifuge, recover ethanol from the filtrate and concentrate it into a thick paste; Ethanol and concentrated into a thick ointment; the dregs were extracted with water and ultrasonic wave for 30 minutes, centrifuged, and the filtrate was concentrated into a thick ointment;

[0050] 2) Tablet pressing: Grind notoginseng into fine powder, make granules with the above-mentioned thick paste and auxiliary materials, dry, grind borneol into fine powder, mix with the above-mentioned granules, and press into 1000 plain tablets;

[0051] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the pot at 35-37°C, and use the continuou...

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Abstract

The invention discloses a preparation method of compound danshen root thin film coated tablets. The preparation method comprises the following steps: (1) performing raw material treatment, namely taking 450 parts by weight of danshen root, 141 parts by weight of panax notoginseng and 8 parts by weight of borneol, adding 95% ethanol into danshen root, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; adding 50% ethanol into medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; and adding water into the medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, and concentrating a filtrate to form a thick paste; (2) tabletting, namely crushing panax notoginseng into fine powder, mixing with the thick pastes and auxiliary materials to prepare granules, drying, finely grinding borneol, uniformly mixing with the granules, and pressing to obtain compressed tablets; and (3) coating, namely putting the compressed tablets into a coating pan, and treating the compressed tablets by adopting a trundle pan coating process until coating liquid is completely sprayed, wherein the use amount of the coating liquid is 0.02-0.05 parts by weight, and the coating liquid consists of the following components in percentage by weight: 10-15% of sodium hydroxyethyl cellulose, 10-15% of a grosvener siraitia extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and the balance of purified water.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of compound salvia miltiorrhiza film-coated tablets. Background technique [0002] Pharmaceutical coating is to spray a thin film with good stability on the tablet embryos pressed from raw materials to cover up the taste of the drug tablet itself and increase the stability of the tablet, avoiding chemically active drugs and other substances Deterioration due to chemical reaction, etc. The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients accessories. Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight g...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K47/46A61K9/36A61K31/045
Inventor 苏世彪
Owner 广西世彪药业有限公司
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