Injectable active bone-repair material and preparation method thereof

A technology for bone repair and activity, applied in medical science, prostheses, coatings, etc., can solve problems such as poor matching between degradation rate and bone reconstruction rate, unfavorable osteoblast ingrowth and blood vessel growth, small pore size and porosity, etc. , to achieve the effect of good osteoconductivity, good surface activity and biocompatibility, good plasticity and mechanical strength

Inactive Publication Date: 2015-04-01
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of low strength in the later stage of calcium sulfate hemihydrate bone repair materials in the prior art, poor matching between degradation speed and bone reconstruction speed, small pore size and porosity, and unfavorable growth of osteoblasts and blood vessels, the present invention provides a An injectable active bone repair material, which uses calcium sulfate hemihydrate and porous hydroxyapatite modified by arginine-glycine-aspartic acid (RGD) in combination in the injectable active bone repair material

Method used

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  • Injectable active bone-repair material and preparation method thereof
  • Injectable active bone-repair material and preparation method thereof
  • Injectable active bone-repair material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The use of the injectable active bone repair material of embodiment 1

[0034] Fully blend the obtained powdery injectable active bone repair material with water for injection at a ratio of 0.8ml / g (liquid-solid ratio) to form a pasty injectable active bone repair material body with an appropriate viscosity that meets the injection requirements After that, it can be used by injection with the corresponding syringe.

[0035] Experimental results show that the initial setting time (injectable time) of the injectable active bone repair material is generally 5 minutes to 6 minutes, and the final setting time (curing time) is 15 minutes.

[0036] The experimental results show that the compressive strength of the injectable active bone repair material after solidification can reach 28MPa, exceeding the compressive strength of human cancellous bone. The results of experimental testing show that the porosity after curing is between 20%-30%, and the pore diameter is between...

Embodiment 2

[0039] The use of the injectable active bone repair material of embodiment 2

[0040] Fully blend the obtained powdery injectable active bone repair material with water for injection at a ratio of 0.8ml / g (liquid-solid ratio) to form a pasty injectable active bone repair material body with an appropriate viscosity that meets the injection requirements After that, it can be used by injection with the corresponding syringe.

[0041] Experimental results show that the initial setting time (injectable time) of the injectable active bone repair material is generally 5 minutes to 6 minutes, and the final setting time (curing time) is 16 minutes.

[0042] The experimental results show that the compressive strength of the injectable active bone repair material after solidification can reach 28MPa, exceeding the compressive strength of human cancellous bone. The results of experimental testing show that the porosity after curing is between 20%-30%, and the pore diameter is between...

Embodiment 3

[0045] The use of the injectable active bone repair material of embodiment 3

[0046] Fully blend the obtained powdery injectable active bone repair material with water for injection at a ratio of 0.8ml / g (liquid-solid ratio) to form a pasty injectable active bone repair material body with an appropriate viscosity that meets the injection requirements After that, it can be used by injection with the corresponding syringe.

[0047] Experimental results show that the initial setting time (injectable time) of the injectable active bone repair material is generally 5 minutes to 6 minutes, and the final setting time (curing time) is 16 minutes.

[0048] The experimental results show that the compressive strength of the injectable active bone repair material after solidification can reach 28MPa, exceeding the compressive strength of human cancellous bone. The results of experimental testing show that the porosity after curing is between 20%-30%, and the pore diameter is between...

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Abstract

The invention relates to an injectable active bone-repair material and a preparation method thereof. The injectable active bone-repair material is prepared from calcium sulfate hemihydrate and arginine, glycine and aspartic acid (RGD)-modified porous hydroxyapatite by adopting a high-energy ball milling dispersing technology. The injectable active bone-repair material provided by the invention has the characteristics of being good for the ingrowth of cells and the formation of new bones and being beneficial to promoting the anchorage-dependent growth of osteoblasts in a human body and accelerating the formation of new bones. In addition, the injectable active bone-repair material has the advantages of being injectable and incapable of causing immunological rejection reaction and can meet the needs of clinical treatment of bone defects.

Description

technical field [0001] The invention relates to an injectable active bone repair material and a preparation method thereof, belonging to the field of materials for bone grafting operations. Background technique [0002] In our country, there are millions of cases of bone nonunion caused by trauma, treatment of bone defects, limb salvage treatment of bone tumors, and some reconstructive surgery patients need to use bone graft materials. At present, the clinically used bone graft materials mainly include autologous bone, allogeneic bone and various artificial bone graft material substitutes. Autologous bone grafting is considered the gold standard for bone grafting due to its good osteoconductive, inductive, and osteogenic capabilities without the risk of disease transmission. However, the treatment method of autologous bone will cause secondary deformity in the bone extraction area and increase the pain of the patient. Allogeneic bone grafts and heterogeneous bone grafts ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/54A61L27/56A61L27/12A61L27/02A61L27/34
Inventor 甘少磊韦兴陈秉耀任卫卫
Owner 北京博恩康生物科技有限公司
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