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A kind of nano-artificial bone scaffold similar to natural bone structure and preparation method thereof

A technology of artificial bone and natural bone, applied in the field of nano-artificial bone scaffold and its preparation, achieving the effect of simple production method, excellent biocompatibility, and good biomechanical strength

Active Publication Date: 2017-04-12
德普斯医疗器械湖州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the problems caused by the cell proliferation and biomechanical properties of the artificial bone scaffold prepared by the traditional preparation method, the present invention innovates and improves the production method during the production process.

Method used

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  • A kind of nano-artificial bone scaffold similar to natural bone structure and preparation method thereof
  • A kind of nano-artificial bone scaffold similar to natural bone structure and preparation method thereof
  • A kind of nano-artificial bone scaffold similar to natural bone structure and preparation method thereof

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Effect test

Embodiment 1

[0046] Embodiment 1: Preparation of nano-hydroxyapatite / polycaprolactone artificial bone scaffold similar to natural bone structure of 10%HA

[0047] Using liquid nitrogen as a refrigerant, the polycaprolactone particles with a diameter of about 3-5 mm were crushed into particles of 110±20 μm by cryogenic crushing technology for later use. 1 kg of nano-HA powder with a particle size of 40 ± 10 nm was mixed with 9 kg of prepared PCL powder to obtain 10 kg of nano-HA / PCL mixed powder with a mass ratio of HA of 10%. Pour the nano-HA / PCL mixed powder into the container of the V-type mixer, and rotate forward (clockwise) and reverse (counterclockwise) for 1 hour each to obtain a uniformly mixed nano-HA / PCL mixed powder (see figure 2 ). Use the 3D graphic design software (Unigraphics NX4.0, American EDS company) on the computer to design the 3D model of computer aided design (COMPUTER AIDED DESIGN, CAD). Artificial bone scaffold models of natural bone structures (see image 3 ),...

Embodiment 2

[0048] Example 2: Preparation of nano-hydroxyapatite / polycaprolactone artificial bone scaffold with 20% HA transverse gradient pore structure.

[0049] Using liquid nitrogen as a refrigerant, the polycaprolactone particles with a diameter of about 3-5 mm were crushed into particles of 110±20 μm by cryogenic crushing technology for later use. 2 kg of nano-HA powder with a particle size of 40 ± 10 nm was mixed with 8 kg of prepared PCL powder to obtain 10 kg of nano-HA / PCL mixed powder with a mass ratio of HA of 10%. Pour the nano-HA / PCL mixed powder into the container of the V-shaped mixer, and rotate forward (clockwise) and reverse (counterclockwise) for 1 hour each to obtain a uniformly mixed nano-HA / PCL mixed powder. Use 3D graphics design software on the computer to design a 3D model of computer aided design (COMPUTER AIDEDDESIGN, CAD). The outer layer is a dense structure similar to cortical bone without pores; the inner layer is a pore structure with a size of 100-300 μm...

Embodiment 3

[0050] Example 3: Preparation of nano-hydroxyapatite / polycaprolactone artificial bone scaffold with 30% HA transverse gradient pore structure.

[0051] Using liquid nitrogen as a refrigerant, the polycaprolactone particles with a diameter of about 3-5 mm were crushed into particles of 110±20 μm by cryogenic crushing technology for later use. 3 kg of nano-HA powder with a particle size of 40 ± 10 nm was mixed with 7 kg of prepared PCL powder to obtain 10 kg of nano-HA / PCL mixed powder with a mass ratio of HA of 10%. Pour the nano-HA / PCL mixed powder into the container of the V-shaped mixer, and rotate forward (clockwise) and reverse (counterclockwise) for 1 hour each to obtain a uniformly mixed nano-HA / PCL mixed powder. Use 3D graphics design software on the computer to design a 3D model of computer aided design (COMPUTER AIDEDDESIGN, CAD). The outer layer is a dense structure similar to cortical bone without pores; the inner layer is a pore structure with a size of 100-300 μm...

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Abstract

The invention relates to the technical field of medical artificial bone transplantation materials. At present, bone transplantation is widely distributed in multiple fields such as orthomorphia, oral cavity, craniofacial region and the like. But all preparation methods of artificial bone transplantation materials have the problems that the manufacture period is long, the yield is low, and prepared artificial bone transplantation materials do not have precise anatomical morphology same to that of natural bone, and the like. The invention aims at providing a nanometer artificial bone scaffold possessing good bioactivity and excellent mechanical properties and a structure similar to that of natural bone. A selective laser sintering technology is employed, poly-epsilon-caprolactone and hydroxylapatite are taken as raw materials, and layer-by-layer sintering is performed according to a designed model and set parameters, and finally the artificial bone scaffold with the structure similar to that of natural bone is obtained. The artificial bone scaffold has outstanding biocompatibility, cells have relatively high propagation rate on the artificial bone scaffold, and the scaffold keeps good biomechanical properties.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a nano-artificial bone support similar to natural bone structure and a preparation method thereof. Background technique [0002] At present, bone transplantation has become the second only to blood transfusion in human tissue transplantation, widely distributed in many fields such as orthopedics, oral cavity and craniofacial. People have used polycaprolactone (poly-e-caprolactone, PCL) to construct three-dimensional bone tissue engineering porous scaffolds and achieved success. These degradable materials have been proved to have good biocompatibility. And hydroxyapatite (hydroxyapatite, HA) has good biocompatibility and bioactivity, and can form a strong chemical bond with bone on the interface after being implanted into bone tissue, and has osteoconduction and osteoinductivity. HA block ceramics have been used in clinical bone repair and replacem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/153B29C64/393B29C64/314A61F2/28B33Y50/02B33Y30/00B33Y40/00
Inventor 许硕贵王红英夏琰张艳艳周潘宇程晓松
Owner 德普斯医疗器械湖州有限公司
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